Cytoprotective effects ofCyperus rotundus against ethanol induced gastric ulceration in rats

Zhu, Min; Luk, Hing-Sun; Fung, H. S.; Luk, C.T.

doi:10.1002/(sici)1099-1573(199708)11:5<392::aid-ptr113>3.0.co;2-1

Cited by 60 publications

(29 citation statements)

References 6 publications

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“…Decoctions of Cyperus rotundus rhizome were given orally (1.25, 2.5, 4.0 g crude drug/kg) to rats 30 min before ethanol showed gastric ulcer inhibitory effect in a dose dependent manner [114]. The ulcer-preventive role of Cyperus rotundus was studied in rats treated with non-steroidal anti-inflammatory drugs.…”

Section: Gastrointestinal Effectmentioning

confidence: 99%

A review on Cyperus rotundus A potential medicinal plant

Al-Snafi¹

2016

IOSRPHR

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Abstract:-Many previous studies showed Cyperus rotundus contained flavonoids, tannins, glycosides, furochromones, monoterpenes, sesquiterpenes, sitosterol, alkaloids saponins, terpenoids, essential oils, starch, carbohydrates, protein, separated amino acids and many other secondary metabolites. The previous works also showed that the plant exerted antiparasitic, insecticidal, repellent, antibacterial, antioxidant, anticancer, central nervous, neuroprotective, antiinflammatory, antipyretic, analgesic, hypolipidemic, weight control, antiplatelet, gastrointestinal, hepatoprotective, antidiabetic, anti-dysmenorrhea, dermatological and many other effects. This review was designed to highlight the chemical constituents and pharmacological effects of Cyperus rotundus.

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Section: Gastrointestinal Effectmentioning

confidence: 99%

A review on Cyperus rotundus A potential medicinal plant

Al-Snafi¹

2016

IOSRPHR

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“…C. rotundus has been called "the world's worst weed" as it is known as a weed in over 90 countries and infests over 50 crops worldwide. On the other hand, it is a traditional herbal medicine used widely as analgesic, sedative, antispasmodic, antimalarial, stomach disorders and to relieve diarrhea ( Zhu, Luk, Fung, & Luk, 1997). The tuber part of C. rotundus is one of the oldest known medicinal plants used for the treatment of dysmenorrhea and menstrual irregularities ( Bhattarai, 1993).…”

Section: Introductionmentioning

confidence: 99%

Physicochemical properties and starch digestibility of Scirpus grossus flour and starch

Lerdluksamee

Srikaeo

Mir-Tutusaus

et al. 2013

Carbohydrate Polymers

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Flour and starch isolated from the tubers of Scirpus grossus were investigated for their physicochemical properties and starch digestibility. The flour was extracted using two different processes namely peeled and unpeeled processes. Proximate analysis revealed that the flours from both processes contain considerably high total starch, more than 80%, which indicate their potential use as starchy foods. The amylose content of the flours and starches ranged from 29 to 32%. Starch granules of S. grossus were oval in shape with smooth surface and small diameters ranging from 6 to 15 μm. All samples exhibited high swelling pasting behaviors with pasting temperatures ranging from 78 to 79 °C, indicating the strong bonding forces within the granule interiors. Differential scanning calorimetry (DSC) results suggested that the samples gelatinized at temperatures ranging from 71 to 81 °C. In vitro starch digestion assay found that all samples provided the estimated glycaemic index (GI) values of approximately 55 or less. Highlights•The flour and starch of Scirpus grossus have the potential to be used as starchy foods.•Their functional properties have not yet been investigated.•This study determined their physicochemical properties.•The findings here suggested that it could be used in low GI food products.

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“…The tuber part of C. rotundus is a commonly used traditional Oriental medicine for treatment of dysmenorrhea and other menstrual irregularities. This herb is also widely used as an analgesic, nerve tonic, nootropic, sedative, anti-spasmodic, anti-malarial, antidiarrheal and a reliever of stomach disorders (13)(14)(15)(16)(17). Previous pharmacological investigations indicated that the extracts and/ or components of C. rotundus rhizomes have marked hypotensive, anti-mutagenic, anti-obese, neuroprotective, antioxidant, anti-inflammatory and anti-pyretic effects (18)(19)(20)(21)(22)(23)(24)(25)(26).…”

Section: Induction Of Apoptosis In Mda-mb-231 Human Breast Carcinoma mentioning

confidence: 99%

Induction of apoptosis in MDA-MB-231 human breast carcinoma cells with an ethanol extract of Cyperus rotundus L. by activating caspases

et al. 2014

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Abstract. Cyperus rotundus L. belongs to the Cyperaceae family and is a well documented traditional medicinal herb. Its rhizome has been reported to possess wide spectrum pharmacological activities including anti-inflammatory and antioxidant activity. However, the cellular and molecular mechanisms of the anticancer activity have not been elucidated. In the present study, we investigated the pro-apoptotic effects of C. rotundu rhizomes in a human breast carcinoma MDA-MB-231 cell model. Treatment of MDA-MB-231 cells with an ethanol extract of C. rotundu rhizomes (EECR) and a methanol extract of C. rotundu rhizomes (MECR), but not a water extract of C. rotundu rhizomes, resulted in potent antiproliferative activity. The activity of the EECR was higher than that of the MECR and was associated with the induction of apoptosis. The induction of apoptosis by the EECR was associated with upregulation of death receptor 4 (DR4), DR5 and pro-apoptotic Bax, as well as downregulation of anti-apoptotic survivin and Bcl-2. EECR treatment also downregulated Bid expression and activated caspase-8 and -9, the respective initiator caspases of the extrinsic and intrinsic apoptotic pathways. The increase in mitochondrial membrane depolarization was correlated with activation of effector caspase-3 and cleavage of poly(ADP-ribose) polymerase, a vital substrate of activated caspase-3. Blockage of caspase activation by pretreatment with a pan-caspase inhibitor consistently inhibited apoptosis and abrogated growth inhibition in EECR-treated MDA-MB-231 cells. Although reactive oxygen species (ROS) increased following treatment with the EECR, inhibiting ROS with a ROS scavenger did not attenuate EECR-induced apoptosis. Furthermore, inhibitors of phosphatidylinositol 3-kinase (PI3K)/Akt and mitogen-activated protein kinase (MAPK) signaling pathways failed to reverse EECR-induced apoptosis and growth inhibition. These results suggest that the pro-apoptotic activity of the EECR may be regulated by a caspase-dependent cascade through activation of both intrinsic and extrinsic signaling pathways that is not associated with ROS generation or the PI3K/Akt and MAPK pathways.

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Cytoprotective effects ofCyperus rotundus against ethanol induced gastric ulceration in rats

Cited by 60 publications

References 6 publications

A review on Cyperus rotundus A potential medicinal plant

A review on Cyperus rotundus A potential medicinal plant

Physicochemical properties and starch digestibility of Scirpus grossus flour and starch

Induction of apoptosis in MDA-MB-231 human breast carcinoma cells with an ethanol extract of Cyperus rotundus L. by activating caspases

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