Cytoprotective effect of piperine against benzo[a]pyrene induced lung cancer with reference to lipid peroxidation and antioxidant system in Swiss albino mice

Selvendiran, K.; Singh, Jaswant; Kathiravan, K.; Sakthisekaran, Dhanapal

doi:10.1016/s0367-326x(02)00304-0

Cited by 139 publications

(73 citation statements)

References 20 publications

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“…Piperine (PIP) is a major alkaloid of black pepper. Recent studies on the pharmacological actions of PIP have demonstrated its cytoprotective effect and antioxidant activity, 1,2) immunomodulatory and antitumor activity, 3) and inhibitory action on drug-metabolizing enzymes in rodents. 4) The results from animal experiments showed that PIP possesses antidepression hyphen like activity and cognitive-enhancing effect after chronic oral administration.…”

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confidence: 99%

Neuroprotective Effect of Piperine on Primarily Cultured Hippocampal Neurons

Sun

Zuo

2010

Biological & Pharmaceutical Bulletin

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It was previously reported that piperine (PIP) significantly blocks convulsions induced by intracerebroventricular injection of threshold doses of kainate, but had no or only slight effects on convulsions induced by L-glutamate, N-methyl-D-aspartate and guanidinosuccinate. In traditional Chinese medicine, black pepper has been used for epileptic treatment; however, the exact mechanism is still unclear. We reported here in that appropriate concentration of PIP effectively inhibites the synchronized oscillation of intracellular calcium in rat hippocampal neuronal networks and represses spontaneous synaptic activities in terms of spontaneous synaptic currents (SSC) and spontaneous excitatory postsynaptic currents (sEPSC). Moreover, pretreatment with PIP expects protective effect on glutamate-induced decrease of cell viability and apoptosis of hippocampal neurons. These data suggest that the neuroprotective effects of PIP might be associated with suppression of synchronization of neuronal networks, presynaptic glutamic acid release, and Ca 2؉ overloading.

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confidence: 99%

Neuroprotective Effect of Piperine on Primarily Cultured Hippocampal Neurons

Sun

Zuo

2010

Biological & Pharmaceutical Bulletin

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“…Dose selection: Doses were selected according to LD 50 dose of allethrin for mice. Curcuminand piperinedose was selected according to previous studies performed by other researchers 19,20 and curcumin's pharmacological safety is accepted, considering that it has been consumed as a dietary spice, at doses up to 100 mg dayG 1 , for centuries 21 . The untreated control mice were treatedidentically with equal volumes of olive oil.…”

Section: Methodsmentioning

confidence: 99%

Prophylactic Role of Piperine and Curcumin in Allethrin Altered Hematological and Biochemical Parameters in Swiss Albino Mice

Kumar¹,

Divakar²,

Sasmal³

et al. 2015

Pharmacologia

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Background: Over the years, pyrethroids, including allethrin, are widely used for domestic and agricultural purposes and are found to be neurotoxic. However, effects on hematological and biochemical parametersare not elucidated. Thus, the first objective of the present study was to investigate the effect of allethrin on the hematological and biochemical parameters of Swiss albino mice. Further, for the amelioration of its effect, two different bioactive herbal extracts piperine (alkaloid) and curcumin (polyphenols) were evaluated. Methods: Animals were divided into six groups; the first group was used as a control. Groups 2, 3, 4, 5 and 6 were orally treated with allethrin (15 mg kgG .wt.), respectively for 28 days. Results: Administration of allethrin brought about a significant decrease in leukocytes, polymorphs, serum albumin, HDL, glucose and CPK and whereas, lymphocytes, haemoglobin, ALT, AST, serum creatinine, blood urea, total cholesterol, LDL, VLDL, triglycerides was found to be significantly increased following allethrin treatment. Gravimetric indices (body weight and organ weight) slightly declined following allethrin treatment. Further, the histopathological observations in allethrin treated mice showed the damage in all vital organs (kidney, liver, lungs, brain and heart) of Swiss albino mice. Administration of piperine and curcumin exhibited signi cant reversal of allethrin altered hematological and biochemical parameters. ALT, AST, serum creatinine, blood urea, serum albumin, HDL, glucose found to be comparable to that of the control group after piperine and curcumin administration. The presence of piperine and curcumin with allethrin preserved the normal histological architecture of the liver, kidney, lungs, brain and heart. Conclusion: These results indicate that piperine and curcumin can be a potent protective agent against allethrinalteredbiochemical and hematological alterations in mice.

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“…Ramakrishnan et al [40] cited decreased SOD activities, Vinodhkumar et al, [41] showed decreased CAT in various carcinogenic conditions that may be due to the increased LPO. Decline in GPx activity may be attributed to the reduction in the levels of reduced GSH and increase in the level of peroxides during carcinogenesis [42].…”

Section: Palanisamy and Samiappanmentioning

confidence: 99%

Antioxidant and Chemotherapeutic Potential of Curcuma Amada Rhizome Extract on Benzo(a)pyrene Induced Cervical Carcinoma in Sprague Dawley Rats

Devaraj

Samiappan²

2017

Asian J Pharm Clin Res

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Objective: To evaluate the antioxidant and chemotherapeutic potential of Curcuma amada Rhizome extract on benzo(a)pyrene (BaP) induced cervical carcinoma in Sprague Dawley rats.Methods: A total of 30 female Sprague Dawley rats were selected to establish cervical cancer model and then divided into 5 groups at random with six mice in each group. Group 1 control, Group 2 BaP (oral), Group 3 BaP for 8 weeks and post-treated with cisplatin (intravenous administration), Group 4 BaP for 8 weeks and post-treated with 250 mg of ethanol extract of C. amada (oral), Group 5 BaP for 8 weeks and post-treated with 500 mg of ethanol extract of C. amada (oral). 4 weeks after the treatment, the animals were sacrificed, serum separated, and cervical tissues were dissected. Antioxidants and the markers carcinoembryonic antigen (CEA), cancer antigens (CAs) 125, gamma glutamyltransferase (GTT) were assayed in serum and the tissue was used for analyzing tumor burden and sectioned for histopathological assays.10% tissue homogenate was estimated for antioxidants and membrane-bound enzymes.Results: BaP treated group showed significant (p<0.001) incidence of tumor burden, decreased activities of antioxidants, elevated lipid peroxidation, Na Conclusion:From the results, it can be concluded that C. amada Rhizome extract ameliorated BaP induced oxidative stress in the cervical carcinogenicity of rats.

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Cytoprotective effect of piperine against benzo[a]pyrene induced lung cancer with reference to lipid peroxidation and antioxidant system in Swiss albino mice

Cited by 139 publications

References 20 publications

Neuroprotective Effect of Piperine on Primarily Cultured Hippocampal Neurons

Neuroprotective Effect of Piperine on Primarily Cultured Hippocampal Neurons

Prophylactic Role of Piperine and Curcumin in Allethrin Altered Hematological and Biochemical Parameters in Swiss Albino Mice

Antioxidant and Chemotherapeutic Potential of Curcuma Amada Rhizome Extract on Benzo(a)pyrene Induced Cervical Carcinoma in Sprague Dawley Rats

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