Cytoprotective effect of Centella asiatica is mediated through the modulation of mitochondrial voltage-dependent anion channel (VDAC) and scavenging of free radicals

Tewari, Debanjan; Mukhopadhyay, Mohona; Nekkanti, Madhav Siva; Vallabhaneni, Sirisha; Sahu, Giriraj; Jetti, Suresh Kumar; Preethidan, D.S.; Bera, Amal Kanti

doi:10.1016/j.jff.2015.11.047

Cited by 11 publications

(5 citation statements)

References 48 publications

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“…[35] This antioxidant capacity, as well as the modulation of voltage-dependent anion channel (VDAC) in the mitochondria, was cytoprotective for neural cell lines. [36]…”

Section: Discussionmentioning

confidence: 99%

Enhancing cognitive function of healthy Wistar rats with aqueous extract of Centella asiatica

et al. 2018

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Background: Centella asiatica (L.) Urb is a native herb from Asian countries such as India, China, and Indonesia. This herb has been widely used as a cure for various diseases. However, studies investigating the aqueous extract of Centella asiatica as a nootropic in healthy individuals are still very limited.Objective: This study aims to investigate the potential of aqueous extract of Centella asiatica in enhancing cognitive function of healthy male Wistar rats.Methods: Rats were randomly allocated to four treatment groups, i.e. without treatment and aqueous Centella asiatica extract at doses of 200, 400 and 800 mg/kg. To determine enhancement of cognitive function, novel object recognition (NOR) test was conducted after the course of treatment. Acetylcholine content was assessed by enzyme-linked immunosorbent assay.Results: There was a significantly high preference index towards the novel object in the NOR test in groups treated with 200 mg/kg and 800 mg/kg of the aqueous extract compared to control. This was further confirmed by a significant increase of brain acetylcholine content in rats treated with 200 mg/kg of the extract.Conclusion: Therefore, this study confirms that the aqueous extract is effective in enhancing cognitive performance of healthy Wistar rats.

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“…[35] This antioxidant capacity, as well as the modulation of voltage-dependent anion channel (VDAC) in the mitochondria, was cytoprotective for neural cell lines. [36]…”

Section: Discussionmentioning

confidence: 99%

Enhancing cognitive function of healthy Wistar rats with aqueous extract of Centella asiatica

et al. 2018

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“…Centella asiatica has a cytoprotective effect by suppressing ROS by protecting the mitochondrial membrane through an increase in VDAC [61]. Another study stated that this plant protects rotenone by protecting the mitochondrial membrane potential, reducing apoptosis of dopaminergic neurons [27].…”

Section: Figure 1 the Growth Of The Average Body Length Of Zebrafish ...mentioning

confidence: 99%

The effect of Centella asiatica ethanolic extract on expression of glucose transporter 1 and osteocalcin on stunting larvae of Zebrafish (Danio rerio)

Yuningsih¹,

Wardani²,

Movafeghi³

et al. 2022

GSC Biol. and Pharm. Sci.

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Stunting is known as length for age below minus two standard deviations (<-2 SD) of the WHO Child Growth Standard nutritional status. Several causes are identified, including exposure to pesticides (rotenone), which works by inhibiting mitochondrial complex I as an ATP-producing site and generate oxidative stress that affects glucose delivery and bone elongation involving GLUT 1 and osteocalcin. Centella asiatica is a high antioxidant herbal plant with anti-inflammatory properties. This study aimed to investigate the effect of Centella asiatica ethanolic extract on the rotenone-induced stunting zebrafish (Danio rerio) larvae model through GLUT 1 and osteocalcin expressions. This study found that 12.5 ppb of rotenone can induce about 6 dpf (day post-fertilization) zebrafish larvae into stunting. The effect of Centella asiatica ethanolic extract on increasing body length in stunting zebrafish larvae works by increasing the expression of GLUT 1 and osteocalcin expressions. The correlation test showed a positive and strong relationship between this ethanolic extract level with GLUT 1 and Osteocalcin expression. Thus, the Centella asiatica ethanolic extract effectively promotes the body length by elevating the expression of GLUT 1 and osteocalcin in stunting zebrafish larvae.

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“…In a separate study, the CA phytochemical asiaticoside was found to inhibit Aβ-induced neuronal apoptosis by restoring and maintaining mitochondrial membrane potential ( Song et al, 2018 ). Several potential molecular mechanisms mediating the mitoprotective effects of CA have been proposed, including increased conductance and stabilization of VDAC ( Tewari et al, 2016 ). VDAC plays a critical role in cell survival, transport of substrates for energy production and maintenance of mitochondrial membrane potential ( Camara et al, 2017 ), making it a target of interest in regulating mitochondrial function.…”

Section: Targeting Mitochondria In Aging and Neurodegenerative Disease: Role For Centella Asiatica (L) Urbmentioning

confidence: 99%

“…CA has a wide range of ethnomedical applications, including treatment of gastrointestinal disorders, skin diseases, fever, and cognitive and memory problems ( Gohil et al, 2010 ; Jahan et al, 2012 ; Sabaragamuwa et al, 2018 ). Studies of the plant extract and its bioactive compounds have revealed a broad range of pharmacological and therapeutic effects, including anti-ulcer ( Zheng et al, 2016 ), anti-microbial ( Idris and Nadzir, 2017 ), cytoprotective ( Choi et al, 2016 ; Tewari et al, 2016 ), anti-inflammatory ( Choi et al, 2016 ; Park et al, 2017 ; Ho et al, 2018 ), anti-oxidant ( Zhao et al, 2014 ; Dewi and Maryani, 2015 ; Intararuchikul et al, 2019 ) and mitoprotective ( Gray et al, 2017 ; Zhang et al, 2017 ; Gray et al, 2018c ) properties. The bioactive components of CA readily cross the blood brain barrier and exert beneficial neuroactive effects in a range of models of aging ( Zweig et al, 2021 ) and neurodegenerative disease including Alzheimer’s disease (AD) ( Gray et al, 2018c ; Matthews et al, 2019 ) and Parkinson’s disease (PD) ( Gopi and Arambakkam Janardhanam, 2017 ; Teerapattarakan et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Mitoprotective Effects of Centella asiatica (L.) Urb.: Anti-Inflammatory and Neuroprotective Opportunities in Neurodegenerative Disease

2021

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Natural products remain a crucial source of drug discovery for accessible and affordable solutions for healthy aging. Centella asiatica (L.) Urb. (CA) is an important medicinal plant with a wide range of ethnomedicinal uses. Past in vivo and in vitro studies have shown that the plant extract and its key components, such as asiatic acid, asiaticoside, madecassic acid and madecassoside, exhibit a range of anti-inflammatory, neuroprotective, and cognitive benefits mechanistically linked to mitoprotective and antioxidant properties of the plant. Mitochondrial dysfunction and oxidative stress are key drivers of aging and neurodegenerative disease, including Alzheimer’s disease and Parkinson’s disease. Here we appraise the growing body of evidence that the mitoprotective and antioxidative effects of CA may potentially be harnessed for the treatment of brain aging and neurodegenerative disease.

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Cytoprotective effect of Centella asiatica is mediated through the modulation of mitochondrial voltage-dependent anion channel (VDAC) and scavenging of free radicals

Cited by 11 publications

References 48 publications

Enhancing cognitive function of healthy Wistar rats with aqueous extract of Centella asiatica

Enhancing cognitive function of healthy Wistar rats with aqueous extract of Centella asiatica

The effect of Centella asiatica ethanolic extract on expression of glucose transporter 1 and osteocalcin on stunting larvae of Zebrafish (Danio rerio)

Mitoprotective Effects of Centella asiatica (L.) Urb.: Anti-Inflammatory and Neuroprotective Opportunities in Neurodegenerative Disease

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