Cytoprotective and Cytotoxic Effects of Rice Bran Extracts in Rat H9c2(2‐1) Cardiomyocytes

Xian, Tan; Bhave, Mrinal; Fong, Alan Yean Yip; Matsuura, Eiji; Kobayashi, Kazuo; Shen, Lian Hua; Hwang, Siaw San

doi:10.1155/2016/6943053

Cited by 11 publications

(12 citation statements)

References 45 publications

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“…Rice bran is a functional food that has been recognized as globally accessible, but not well known as food that can prevent and control chronic diseases [15,16]. Bioactive food components from rice bran were identified for cancer protective functions related to energy metabolism [17–19], antioxidant [20], and direct anti-neoplastic activity [21,22].…”

Section: Introductionmentioning

confidence: 99%

Modulation of plasma and urine metabolome in colorectal cancer survivors consuming rice bran

Zarei

Oppel

Borresen

et al. 2019

Integr Food Nutr Metab

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Rice bran has bioactive phytochemicals with cancer protective actions that involve metabolism by the host and the gut microbiome. Globally, colorectal cancer (CRC) is the third leading cause of cancer-related death and the increased incidence is largely attributed to poor dietary patterns, including low daily fiber intake. A dietary intervention trial was performed to investigate the impact of rice bran consumption on the plasma and urine metabolome of CRC survivors. Nineteen CRC survivors participated in a randomized-controlled trial that included consumption of heat-stabilized rice bran (30 g/day) or a control diet without rice bran for 4 weeks. A fasting plasma and first void of the morning urine sample were analyzed by non-targeted metabolomics using ultrahigh-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). After 4 weeks of either rice bran or control diets, 12 plasma and 16 urine metabolites were significantly different between the groups (p≤0.05). Rice bran intake increased relative abundance of plasma mannose (1.373-fold) and beta-citrylglutamate (BCG) (1.593-fold), as well as increased urine N-formylphenylalanine (2.191-fold) and dehydroisoandrosterone sulfate (DHEA-S) (4.488-fold). Diet affected metabolites, such as benzoate, mannose, eicosapentaenoate (20:5n3) (EPA), and N-formylphenylalanine have been previously reported for cancer protection and were identified from the rice bran food metabolome. Nutritional metabolome changes following increased consumption of whole grains such as rice bran warrants continued investigation for colon cancer control and prevention attributes as dietary biomarkers for positive effects are needed to reduce high risk for colorectal cancer recurrence.

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Section: Introductionmentioning

confidence: 99%

Modulation of plasma and urine metabolome in colorectal cancer survivors consuming rice bran

Zarei

Oppel

Borresen

et al. 2019

Integr Food Nutr Metab

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“…The present study demonstrates that pre‐treatment with bran extract for 14 days showed improvement in oxidative stress markers such as MDA, NO, and HP and antioxidant enzyme activities suggesting its potent antioxidant activity. Recent in‐vitro study (Tan et al, ) showed an improved level of expression of antioxidant enzymes activity in rats heart cells on rice bran extract pre‐treatment against H 2 O 2 exposure. Relevant studies associated with rice bran aqueous‐ethanol extracts reported to have antioxidative properties (Jimenez‐Del‐Rio et al, ).…”

Section: Discussionmentioning

confidence: 99%

Inhibition of LPS induced neurochemical imbalance and oxidative stress by pigmented and non-pigmented rice bran extracts

Yadav

Appukuttan

2018

J Food Biochem

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This study evaluated the neuroprotective efficacy of the pigmented and non‐pigmented rice bran extract, against LPS induced neurotransmitter imbalance and oxidative stress markers. Male wistar rats were orally supplemented with 2% ethanolic rice bran extracts daily for two weeks. On the last day of experiment, rats were challenged intraperitoneally (i.p) with LPS for 4 hr. LPS exposure resulted in the elevation of malondialdehyde and nitrite levels, decreased GSH, increased antioxidant enzymes activity and led to imbalance in neurotransmitters, norepinephrine, dopamine and serotonin and their metabolites 3,4‐dihydroxyphenylacetic acid, homovanillic levels and acetylcholinesterase activity. Pre‐treatment with rice bran extracts significantly attenuated LPS induced oxidative stress by improving the antioxidant systems, acetylcholinesterase activity and neurotransmitters imbalance with the higher potency for pigmented bran extracts. The findings suggest the possibility of utilization of pigmented bran extract for the prevention of neurodegenerative diseases and promote the overall good health of the brain. Practical application Present study provides the current evidence for the neuroprotective efficacy of bran extracts from pigmented and non‐pigmented rice. These findings indicate the beneficial effects of pre‐treatment of rice bran extracts on LPS induced oxidative stress and neurochemical imbalance by improvement in the antioxidant machinery and neurotransmitters level. This study emphasizes the possibility of utilization of pigmented bran extract as a food ingredient to improve the overall brain health.

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“…For example, fermented rice bran extract was shown to inhibit ROS generation in cultured adipocytes subjected to H 2 O 2 -induced oxidative stress [ 42 ]. Further, pre-treatment with rice bran extract on rats’ heart cells exposed to H 2 O 2 was also found to increase both the activity and the level of expression of antioxidant enzyme catalase [ 43 ]. Such studies confirm the above in vitro studies regarding the inhibitory effect of rice bran intake on ROS production in cancer cell lines.…”

Section: Evidence For the Anti-oxidative Effects Of Rice Branmentioning

confidence: 99%

Hypotheses on the Potential of Rice Bran Intake to Prevent Gastrointestinal Cancer through the Modulation of Oxidative Stress

Law

Waye

2017

IJMS

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Previous studies have suggested the potential involvement of oxidative stress in gastrointestinal cancers. In light of this, research efforts have been focused on the potential of dietary antioxidant intake to prevent gastrointestinal cancer through the modulation of oxidative stress. Rice bran, a by-product of rice milling, has been shown to contain an abundance of phytochemicals, which are dietary antioxidants. To date, a number of studies have shown the antioxidative effect of rice bran intake, and some demonstrated that such an effect may contribute to gastrointestinal cancer prevention, largely through the antioxidative properties of rice bran phytochemicals. In addition, these phytochemicals were shown to provide protection against cancer through mechanisms linked to oxidative stress, including β-catenin-mediated cell proliferation and inflammation. The present article provides an overview of current evidence for the antioxidative properties of rice bran and its phytochemicals, and for the potential of such properties in cancer prevention through the oxidative-stress-linked mechanisms mentioned above. The article also highlights the need for an evaluation of the effectiveness of rice bran dietary interventions among cancer survivors in ameliorating oxidative stress and reducing the level of gastrointestinal cancer biomarkers, thereby establishing the potential of such interventions among these individuals in the prevention of cancer recurrence.

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Cytoprotective and Cytotoxic Effects of Rice Bran Extracts in Rat H9c2(2‐1) Cardiomyocytes

Cited by 11 publications

References 45 publications

Modulation of plasma and urine metabolome in colorectal cancer survivors consuming rice bran

Modulation of plasma and urine metabolome in colorectal cancer survivors consuming rice bran

Inhibition of LPS induced neurochemical imbalance and oxidative stress by pigmented and non-pigmented rice bran extracts

Hypotheses on the Potential of Rice Bran Intake to Prevent Gastrointestinal Cancer through the Modulation of Oxidative Stress

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