Cytoprotective and antioxidant effects of the edible halophyte Sarcocornia perennis L. (swampfire) against lead-induced toxicity in renal cells

Gargouri, Manel; Magné, Christian; Dauvergne, Xavier; Ksouri, Riadh; Feki, Abdelfattah El; Metges, Marie-Agnès; Talarmin, Hélène

doi:10.1016/j.ecoenv.2013.05.011

Cited by 42 publications

(28 citation statements)

References 55 publications

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“…The content was higher in wild plants (6.13 mg GAE g -1 DW) compared with that of another species of Sarcocornia (4.32 mg GAE g -1 DW) (Gargouri et al, 2013). The differences between both plants (wild and cultivated) (Table 3) are probably due to the exposure to different stress conditions.…”

Section: Functional Characterizationmentioning

confidence: 81%

“…Agawu (2012) also reported that the ascorbic acid content declined remarkably under NaCl stress. The ascorbic acid content in S. perennis (8289 mg g -1 DW) (Gargouri et al, 2013) was much higher than the values found in wild and cultivated S. neei (0.55-0.9 mg g -1 DW) and comparable with other green leafy vegetables such spinach (0.22-0.31 mg g -1 DW) (Favell, 1998). Finally, the LAA in wild and cultivated plants (1.81 and 1.87 µmoles TE g -1 DW, respectively) as a green leafy vegetable were lower than the values reported for lettuce (23.26 µmoles TE g -1 DW) (Wu et al, 2004).…”

Section: Functional Characterizationmentioning

confidence: 99%

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NUTRITIONAL AND FUNCTIONAL CHARACTERIZATION OF WILD AND CULTIVATED Sarcocornia neei GROWN IN CHILE

et al. 2016

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Sarcocornia neei is a halophyte that grows on the coast of the Valparaiso Region of Chile. Studies related to its nutritional and functional value under wild and cultivated conditions are not available. Thus, in this study, a nutritional (complete proximal, mineral and dietary fiber analysis) and functional characterization (total phenolics, β-carotene, hydrophilic and lipophilic antioxidant activity (HAA and LAA) and ascorbic acid) were performed for wild and cultivated plants. Wild plants displayed higher amounts of compounds involved in stress defense mechanisms such as total phenolics, proteins, dietary fiber and ash. The mineral analysis revealed that Na + and Cl -are the main ions accumulated in wild and cultivated Sarcocornia neei that are present in significantly higher amounts in the cultivated plants. The functional characterization revealed higher amounts of dietary fiber, total phenolics and HAA in wild plants than in cultivated plants. Similar contents of β-carotene, LAA and ascorbic acid were found for wild and cultivated plants. The results from this study provide information on the potential of Sarcocornia neei to be consumed as a leafy green vegetable with important amounts of main nutrients and functional metabolites.

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Section: Functional Characterizationmentioning

confidence: 81%

Section: Functional Characterizationmentioning

confidence: 99%

NUTRITIONAL AND FUNCTIONAL CHARACTERIZATION OF WILD AND CULTIVATED Sarcocornia neei GROWN IN CHILE

et al. 2016

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“…Field cultivated BTH2 plants had an average FPC content higher than that of ethanolic and methanolic extracts of the vegetative shoots of green (respectively, 1.89 and 1.94 mg GAE g −1 dw; calculated considering 80% shoot water content) and red (respectively, 2.20 and 2.35 mg GAE g −1 dw) wild biotypes of S. neei from southern Brazil, cultivated with saline effluent of shrimp farm [12]. Free phenolic compounds and FFC of BTH2 shoots were higher than those found in methanolic extracts of wild plants of Sarcocornia perennis from Tunisia [37] and Salicornia europaea collected in Tukey [38], which range between 4.32-9.89 mg GAE g −1 dw and 3.3-5.1 mg catechin equivalent (ce) g −1 dw, respectively. The content of phenolic compounds in BTH2 shoots was also equal or greater than that of organic asparagus (FPC = 19.4 mg GAE g −1 dw; FFC = 5.28 mg ce g −1 dw) [39], artichoke (FPC = 0.84 mg GAE g −1 dw; FFC = 0.65 mg ce g −1 dw), spinach (FPC = 0.6 mg GAE g −1 dw; FFC = 0.03 mg ce g −1 dw) [40], broccoli and cauliflower (FPC ranged from 8.24 to 17.2 mg GAE g −1 dw) [41].…”

Section: Responses Of S Neei Genotypes Under Saline Effluent Irrigatmentioning

confidence: 87%

Growth, Phenolics, Photosynthetic Pigments, and Antioxidant Response of Two New Genotypes of Sea Asparagus (Salicornia neei Lag.) to Salinity under Greenhouse and Field Conditions

et al. 2018

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Small succulent halophytic shrubs of the genera Salicornia and Sarcocornia (Salicornioideae, Amaranthaceae) are commonly named sea asparagus and consumed worldwide as green salad in gourmet food, as conserves, and beverages. Their shoots are rich in bioactive compounds and plants show high yields in a wide range of salinities, but little is known about how salt cultivation conditions affect their chemical composition. Two genotypes (BTH1 and BTH2) of the Brazilian sea asparagus Salicornia neei Lag. were evaluated for salt tolerance and changes in shoot concentrations of organic metabolites and antioxidant activity under different salt exposure in both greenhouse and field conditions. All greenhouse plants received full strength modified Hoagland solution in deionized water with a basic electrical conductivity (EC) of 1.7 dS m−1, and with NaCl concentrations (in mM) of ~0.1 (control), 34, 86, 171, 513, and 769. After fifty days of cultivation, both S. neei genotypes showed high salt tolerance and grew better under low salinities (34–86 mM NaCl) than under control salinity. Shoots of BTH1 genotype appeared to be undergoing lignification and used their high carotenoid content to dissipate the oxidative power, and the zeaxanthin content and de-epoxidation state of xanthophylls (DES) were positively affected by salinity. Under increasing salinity, BTH2 genotype had higher relative content of chlorophyll b, which may have lowered the plant photo-oxidation rate, and increased shoot concentration of the flavonoid quercetin (up to 11.6 μg g−1 dw at 769 mM NaCl), leading to higher antioxidant capacity. In the field experiment, after 154 days of irrigation with saline (213 mM NaCl) shrimp farm effluent, BTH2 plants grew taller, produced more metabolites (e.g., total phenolics, total free flavonoids, quercetin, and protocatechuic acid) and had a greater antioxidant capacity of shoots than that of BTH1 plants and that of traditional crops irrigated with fresh water. Yield and bioactive compound composition of S. neei genotypes’ shoots can be enhanced by cultivation under moderate saline conditions.

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“…Regarding the mechanism of the histopathological changes occurred in the kidney, it can be explained by many studies showed that leadinduced kidney injury is associated with a production of ROS, thus inducing oxidative stress; excito-toxicity and DNA damage (Dai et al, 2010;Liu et al, 2012;gargouri et al, 2013). The fact that the kidney organ is rich in mitochondria indicates that it is highly vulnerable to damage caused by oxidative stress (Sureshbabu et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

“…Although several chelating agents have been shown to reduce Pb toxicity, some of them are burdened with undesirable side effects (Aaseth et al, 2015). Accordingly, Pb intoxication therapy is looking for the development of new therapeutic agents with different modes of action especially from the medicinal plants (Gargouri et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Curative Role of D-Penicillamine versus Combined Garlic and Silymarin Extracts on Lead-Induced Nephrotoxicity and Oxidative Stress in Adult Male Albino Rats

Elkhalek

Ibrahim

2015

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

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Background Lead (Pb) poisoning is still an important global health problem, especially in developing countries. Lead has been extensively used for many years ago, and it will continue to be used in future. Aim of work: This study was conducted to compare the curative role of D-penicillamine versus combined garlic and silymarin extracts for treating nephrotoxicity in adult male rats exposed to Pb for 3 months. Material and methods: The study was conducted on 70 adult male albino rats divided into 7 groups each of 10 rats, where they received all chemicals by oral gavage. Groups I & II were the negative and positive control rats, respectively. Group III received 25 mg/kg/day D-penicillamine for 1 month (4 th month). Group IV received combined garlic 20 mg/kg/day+ silymarin 200 mg/kg/day for 1 month (4 th month). Group V received 20 mg/kg/day Pb acetate for 3 months. Group VI received Pb acetate for 3 months followed by D-penicillamine for another 1 month, with the previously mentioned doses. Group VII received Pb acetate for 3 months followed by combined garlic & silymarin for another 1 month, with the previously mentioned doses. At the end of the experimental period (4 months), Pb-level in blood, urine & kidney tissue, kidney function tests (blood urea and serum creatinine) and serum malondialdehyde (MDA) & glutathione peroxidase (GSH-Px) were measured. Light microscopic examination of hematoxylin and eosin stained kidney tissue was performed to detect histopathological changes. Results: Lead administration significantly elevated blood lead level (BLL), kidney lead level (KLL), urinary lead level (ULL) and malondialdehyde (MDA), while glutathione peroxidase (GSH-Px) showed significant decrease when compared with the negative control rats. In Pb treated group, histopathological examination of the kidney revealed extensive tubular damage by presence of necrotic epithelial cells, tubular degeneration, necrosis, cell swelling, mononuclear cell infiltration, and degenerated organelles. Kidney functions didn't show any significant differences among all groups. Treatment of rats by D-penicillamine or combined garlic & silymarin extracts resulted in significant decrease in Pb-levels and MDA with a significant increase in blood GSH-PX levels. Also, significant improvement of lead induced histopathological lesions in the kidneys was observed. Combined garlic and silymarin extract treatment showed more significant improvement than D-penicillamine treated Pb-administered groups, in most of the tested parameters. Conclusion: Both D-penicillamine and combined garlic & silymarin extracts can reduce lead induced nephrotoxicity and oxidative stress. Moreover, garlic & silymarin curative effect is better than that of D-penicillamine. Recommendations: Exposure of the population to lead must be controlled. Search for sensitive blood or urinary marker for early detection of kidney damage and further studies are needed to consider a combination of garlic and silymarin is effective in the treatment of lead-induced toxicities.

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Cytoprotective and antioxidant effects of the edible halophyte Sarcocornia perennis L. (swampfire) against lead-induced toxicity in renal cells

Cited by 42 publications

References 55 publications

NUTRITIONAL AND FUNCTIONAL CHARACTERIZATION OF WILD AND CULTIVATED Sarcocornia neei GROWN IN CHILE

NUTRITIONAL AND FUNCTIONAL CHARACTERIZATION OF WILD AND CULTIVATED Sarcocornia neei GROWN IN CHILE

Growth, Phenolics, Photosynthetic Pigments, and Antioxidant Response of Two New Genotypes of Sea Asparagus (Salicornia neei Lag.) to Salinity under Greenhouse and Field Conditions

Curative Role of D-Penicillamine versus Combined Garlic and Silymarin Extracts on Lead-Induced Nephrotoxicity and Oxidative Stress in Adult Male Albino Rats

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