Cytoprotective Activity of Natural and Synthetic Antioxidants

Valentová, Kateřina

doi:10.3390/antiox9080713

Cited by 12 publications

(7 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Nowadays, the data provided by in vitro and in vivo tests and the association between exogenous antioxidants and their metabolites in the generated therapeutic effects have made antioxidants a hot topic for research [ 226 ]. Despite the phenolic structure that allowed the elucidation of polyphenols’ redox mechanisms, the direct correlation of the antioxidant effect with the beneficial effects in KOA through their metabolites is extremely deficient.…”

Section: The Effects Of Antioxidants In Koamentioning

confidence: 99%

The Implication of Reactive Oxygen Species and Antioxidants in Knee Osteoarthritis

Tudorachi

Totu

Fifere³

et al. 2021

Antioxidants

View full text Add to dashboard Cite

Knee osteoarthritis (KOA) is a chronic multifactorial pathology and a current and essential challenge for public health, with a negative impact on the geriatric patient’s quality of life. The pathophysiology is not fully known; therefore, no specific treatment has been found to date. The increase in the number of newly diagnosed cases of KOA is worrying, and it is essential to reduce the risk factors and detect those with a protective role in this context. The destructive effects of free radicals consist of the acceleration of chondrosenescence and apoptosis. Among other risk factors, the influence of redox imbalance on the homeostasis of the osteoarticular system is highlighted. The evolution of KOA can be correlated with oxidative stress markers or antioxidant status. These factors reveal the importance of maintaining a redox balance for the joints and the whole body’s health, emphasizing the importance of an individualized therapeutic approach based on antioxidant effects. This paper aims to present an updated picture of the implications of reactive oxygen species (ROS) in KOA from pathophysiological and biochemical perspectives, focusing on antioxidant systems that could establish the premises for appropriate treatment to restore the redox balance and improve the condition of patients with KOA.

show abstract

Section: The Effects Of Antioxidants In Koamentioning

confidence: 99%

The Implication of Reactive Oxygen Species and Antioxidants in Knee Osteoarthritis

Tudorachi

Totu

Fifere³

et al. 2021

Antioxidants

View full text Add to dashboard Cite

show abstract

“…These two cytoprotective systems are related in complex functional crosstalk, i.e., (a) some direct antioxidants are required for the catalytic functions of redox proteins and (b) several antioxidant proteins participate in the synthesis and/or homeostasis of direct antioxidants. Direct antioxidants are diverse and common in nature but, importantly and less explored, many inducers of cytoprotective proteins have been isolated from edible plants, e.g., sulforaphane from broccoli and curcumin from turmeric [108,109]; ergothioneine, polyphenols and flavonoids from a variety of edible mushrooms [110,111] and DHA (but not arachidonic acid, the most abundant n-6 LCPUFA, or eicosapentaenoic acid, EPA, the second important n-3 LCPUFA) from different sources, mainly marine fish and invertebrates [112,113].…”

Section: Dha: the Ultimate Indirect Antioxidantmentioning

confidence: 99%

DHA and Its Elaborated Modulation of Antioxidant Defenses of the Brain: Implications in Aging and AD Neurodegeneration

2021

View full text Add to dashboard Cite

DHA (docosahexaenoic acid) is perhaps the most pleiotropic molecule in nerve cell biology. This long-chain highly unsaturated fatty acid has evolved to accomplish essential functions ranging from structural components allowing fast events in nerve cell membrane physiology to regulation of neurogenesis and synaptic function. Strikingly, the plethora of DHA effects has to take place within the hostile pro-oxidant environment of the brain parenchyma, which might suggest a molecular suicide. In order to circumvent this paradox, different molecular strategies have evolved during the evolution of brain cells to preserve DHA and to minimize the deleterious effects of its oxidation. In this context, DHA has emerged as a member of the “indirect antioxidants” family, the redox effects of which are not due to direct redox interactions with reactive species, but to modulation of gene expression within thioredoxin and glutathione antioxidant systems and related pathways. Weakening or deregulation of these self-protecting defenses orchestrated by DHA is associated with normal aging but also, more worryingly, with the development of neurodegenerative diseases. In the present review, we elaborate on the essential functions of DHA in the brain, including its role as indirect antioxidant, the selenium connection for proper antioxidant function and their changes during normal aging and in Alzheimer’s disease.

show abstract

“…Some antioxidants directly scavenge ROS. On the other hand, some induce the Keap1–Nrf2 pathway, resulting in an increased anti-oxidative capacity [ 35 , 36 , 37 ]. Here, we demonstrated that 3-HT and CDA directly scavenged ROS: they counteracted DPPH radicals.…”

Section: Discussionmentioning

confidence: 99%

Fungus-Derived 3-Hydroxyterphenyllin and Candidusin A Ameliorate Palmitic Acid-Induced Human Podocyte Injury via Anti-Oxidative and Anti-Apoptotic Mechanisms

et al. 2022

View full text Add to dashboard Cite

Diabetic nephropathy (DN) is a leading cause of end-stage renal disease. An elevated fatty acid plasma concentration leads to podocyte injury and DN progression. This study aimed to identify and characterize cellular mechanisms of natural compounds that inhibit palmitic acid (PA)–induced human podocyte injury. By screening 355 natural compounds using a cell viability assay, 3-hydroxyterphenyllin (3-HT) and candidusin A (CDA), isolated from the marine-derived fungus Aspergillus candidus PSU-AMF169, were found to protect against PA-induced podocyte injury, with half-maximal inhibitory concentrations (IC50) of ~16 and ~18 µM, respectively. Flow cytometry revealed that 3-HT and CDA suppressed PA-induced podocyte apoptosis. Importantly, CDA significantly prevented PA-induced podocyte barrier impairment as determined by 70 kDa dextran flux. Reactive oxygen species (ROS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) direct scavenging assays indicated that both compounds exerted an anti-oxidative effect via direct free radical–scavenging activity. Moreover, 3-HT and CDA upregulated the anti-apoptotic Bcl2 protein. In conclusion, 3-HT and CDA represent fungus-derived bioactive compounds that have a novel protective effect on PA-induced human podocyte apoptosis via mechanisms involving free radical scavenging and Bcl2 upregulation.

show abstract

Cytoprotective Activity of Natural and Synthetic Antioxidants

Abstract: Numerous chronic diseases including cancer, cardiovascular, chronic respiratory or neurodegenerative diseases, diabetes mellitus, retinal damage, and others are associated with oxidative stress [...]

Cited by 12 publications

References 25 publications

The Implication of Reactive Oxygen Species and Antioxidants in Knee Osteoarthritis

The Implication of Reactive Oxygen Species and Antioxidants in Knee Osteoarthritis

DHA and Its Elaborated Modulation of Antioxidant Defenses of the Brain: Implications in Aging and AD Neurodegeneration

Fungus-Derived 3-Hydroxyterphenyllin and Candidusin A Ameliorate Palmitic Acid-Induced Human Podocyte Injury via Anti-Oxidative and Anti-Apoptotic Mechanisms

Contact Info

Product

Resources

About