Cytoprotection: Shelter from the Storm

Klein, Paula; Muggia, Franco M.

doi:10.1634/theoncologist.4-2-112

Cited by 9 publications

(2 citation statements)

References 47 publications

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“…The selective protection of normal cells, compared with tumor cells, can be explained by the much higher concentration of alkaline phosphatase in normal tissues and by the neutral pH, relative to the acidic pH in tumor cells. 44 A recent metaanalysis of 14 randomized clinical trials indicates that without compromising the efficacy, amifostine treatment significantly ameliorates several side effects such as mucositis, esophagaitis, acute xerostomia, dysphagia, acute pnemonitis, and cystitis during cancer radiotherapy. 45 5.…”

Section: Streptozotocin (Stz) Is a Potent Growth Inhibitormentioning

confidence: 99%

Use of Chemoprotectants in Chemotherapy and Radiation Therapy: The Challenges of Selecting an Appropriate Agent

et al. 2010

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Chemoprotection refers to the protection from the toxicity of one chemical by the intervention of another. Conflicting preclinical and clinical reports make it difficult to either ignore or accept the use of chemoprotectants during cancer chemotherapy or radiotherapy. The selection of anticancer drugs depends on the type and stage of cancer development. However, very little attention has been paid to the selection of chemoprotectants. The answer to the use of chemoprotectants during cancer therapy lies in their appropriate selection in a case-specific and/or issue-specific manner. The need of the hour is to find better answers on the rationality of chemoprotectants selection during cancer therapy using cutting-edge science. In this commentary, we have presented few examples to justify our view-points.

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Section: Streptozotocin (Stz) Is a Potent Growth Inhibitormentioning

confidence: 99%

Use of Chemoprotectants in Chemotherapy and Radiation Therapy: The Challenges of Selecting an Appropriate Agent

et al. 2010

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“…O acúmulo de produtos de peroxidação lipídica contribui para a liberação de fatores pró-apoptóticos no citosol e conseqüentemente para a execução do programa de apoptose (TYURINA et al, 2006 (GRATTAGLIANO et al, 2002;SHAN et al, 1993 (SHEU et al, 2006). No caso específico dos quimioterápicos, a baixa seletividade da ação citotóxica é bastante conhecida e é fundamental que haja efetiva citoproteção dos tecidos saudáveis (KLEIN;MUGGLIA, 1999).…”

Section: Efeito Da Cisplatina Sobre O Fígado: Estresse Oxidativo E Esunclassified

Avaliação do estresse oxidativo e estado redox mitocondrial na hepatotoxicidade induzida pela cisplatina em ratos 'Wistar': efeito protetor da dimetiltiouréia

Martins¹

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effects were prevented by DMTU: (a) elevation of AST and ALT serum levels; (b) decreased hepatic ATP levels; (c) lipid peroxidation; (d) cardiolipin oxidation; (e) sulfhydryl protein oxidation; (f) mitochondrial membrane rigidification; (g) GSH oxidation; (h) NADPH oxidation and (h) apoptotic cell death. Results show the central role of mitochondria and hydroxyl radicals in the protection of healthy liver against cisplatin-induced injury, highlighting a number of steps that might be considered in the development of novel cytoprotective agents.

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Natural compounds as inducers of cell death

Diederich¹,

Noworyta²

2012

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The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a speci fi c statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein.

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Cytoprotection: Shelter from the Storm

Abstract: Above: Photomicrograph of methotrexate, an alkylating agent that injures platelets (pictured below) during chemotherapy.

Cited by 9 publications

References 47 publications

Use of Chemoprotectants in Chemotherapy and Radiation Therapy: The Challenges of Selecting an Appropriate Agent

Use of Chemoprotectants in Chemotherapy and Radiation Therapy: The Challenges of Selecting an Appropriate Agent

Avaliação do estresse oxidativo e estado redox mitocondrial na hepatotoxicidade induzida pela cisplatina em ratos 'Wistar': efeito protetor da dimetiltiouréia

Natural compounds as inducers of cell death

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