Cytoprotection of pancreatic β-cells and hypoglycemic effect of 2-hydroxypropyl-β-cyclodextrin: sertraline complex in alloxan-induced diabetic rats

Effect of Quercetin on Beta cell Regeneration

“…QE has been reported to decrease lipid peroxidation, and increase antioxidant enzymes (Coskun, 2005) resulting in a depletion of oxidative damage to cells. Quercetin thus protects cells undergoing oxidative stress and prevents Ca2+dependent cell death (Buko et al, 2016) thus supporting beta cell regeneration. The regeneration processes are induced by replication of pre-existing betacells, neogenesis from endogenous progenitors or Tran's differentiation from differentiated non-beta cells (Guz et al, 2001).…”

“…Earlier reports state antidiabetic activity of Quercetin by intraperitoneal administration (Ahmed et al, 2010). The protective role of QE against STZ induced oxidative damage has been reported, wherein QE was administered before STZ intraperitoneally (Buko et al, 2016).…”

Thermodynamic Studies of Interactions between Sertraline Hydrochloride and Randomly Methylated β-Cyclodextrin Molecules Supported by Circular Dichroism Spectroscopy and Molecular Docking Results

“…The basis for advanced tests of the cyclodextrins application are still information about inclusion complexation by natural and modified cyclodextrins, as well as the factors involved in controlling the supramolecular interactions [21]. Lately, the interactions between antidepressant drugs and cyclodextrins were examined [22][23][24][25][26], mostly in order to gain the better water solubility of the drug [27][28][29], or to decrease its toxicity [30,31] or even for taste-masking [32]. One of the antidepressants, sertraline hydrochloride, belonging to the class of selective serotonin reuptake inhibitors (SSRIs) [33,34] and also tested as potential anti-Helicobacter pylori compound [35] has already been tested in the presence of β-cyclodextrin and the derivatives [36][37][38][39][40] inter alia in our laboratory [31,41,42].…”

“…The binding process of guest molecule with cyclodextrin was examined with the use of an isothermal titration calorimetry (ITC) [43][44][45] and molecular docking studies (MD) [10,43,45]. The outcome was compared with the set of data for other complexes of SRT with non-ionic β-cyclodextrin derivatives (Figure 1b) received from the literature [31,41,42]. For the thermodynamic results the enthalpy-entropy compensation has been observed.…”

Non-covalent interactions between sertraline stereoisomers and 2-hydroxypropyl-β-cyclodextrin: a quantum chemistry analysis

“…2b, is an example of a functionalized CD, which has been used for several applications. [19][20][21][22][23][24][25] This functionalized CD is obtained by replacing all the secondary alcohols in bCD with 2-hydroxypropyl groups. From a theoretical viewpoint, some structures for the HPbCD:I system have been proposed by using chemical intuition.…”