Cytoplasmic sequences of the growth hormone receptor necessary for signal transduction.

Goujon, Laure; Allevato, Giovanna; Simonin, Ghislaine; Paquereau, Laurent; Cam, Alphonse Le; Clark, J. F.; Nielsen, Jens Høiriis; Djiane, Jean; Postel-Vinay, Marie Catherine; Edery, Marc

doi:10.1073/pnas.91.3.957

Cited by 88 publications

(61 citation statements)

References 26 publications

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“…A GH-responsive spi 2.1 GLE-containing reporter was used in the evaluation of those regions of the GH receptor involved in changes in gene expression. These studies demonstrate that the proline-rich region of the GH receptor required for JAK2 activation is required for spi 2.1 expression (Goujon et al, 1994) and that a GH receptor containing any one of ®ve tyrosines in the cytoplasmic domain is sucient to induce expression of the spi promoter-reporter gene (Enberg et al, 1994).…”

Section: Stat5 Involvement In the Expression Of Serine Protease Inhibmentioning

confidence: 99%

The role of STAT proteins in growth hormone signaling

et al. 2000

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Growth hormone (GH) has long been known to be the body's primary regulator of body growth and a regulator of metabolism, yet the mechanisms by which GH regulates the transcription of speci®c genes required for these processes are just now being delineated. GH binding to its receptor recruits and activates the receptor-associated JAK2 that in turn phosphorylates tyrosines within itself and the GH receptor. These tyrosines form binding sites for a number of signaling proteins, including members of the family of signal transducers and activators of transcription (STAT). Among the known signaling molecules for GH, STAT proteins play a particularly prominent role in the regulation of gene transcription. This paper will review what is currently understood about which STAT proteins are regulated by GH, how they are regulated by GH, the GH-dependent genes they regulate, and discuss current theories about how GH-activated STAT signaling is regulated. Particular attention will be given to the novel role that STAT5 plays in sexually dimorphic gene expression in the liver as determined by the secretory pattern of GH and the role of STAT5 in body growth.

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Section: Stat5 Involvement In the Expression Of Serine Protease Inhibmentioning

confidence: 99%

The role of STAT proteins in growth hormone signaling

et al. 2000

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“…The Box 1 motif comprises of approximately eight prolinerich amino acids, that are required for interaction of several cytokine/growth factor receptors with JAK2. Thus, the Box 1 region of the receptors for prolactin, growth hormone, erythropoietin, IL-6 and related cytokines, that utilize the gp130 signal transducing receptor subunit, is required for association with JAK2 Miura et al, 1994;Tanner et al, 1995;Vanderkuur et al, 1994;Goujon et al, 1994;Hackett et al, 1995;DaSilva et al, 1994). Jiang et al (1996) used mutational analysis to demonstrate that the Box 1 region of cytokine receptors speci®es the region of interaction with JAK kinases.…”

Section: Activation Of Jak Kinases By Cytokines/interferons and Growtmentioning

confidence: 99%

Janus kinases: components of multiple signaling pathways

2000

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“…Predicted signal peptides, transmembrane domains, N glycosylation sites, and other conserved residues/subdomains were boxed with the same color used in (a). Functional prolines in the box I motif (Goujon et al 1994) and tyrosines (Hansen et al 1996) are highlighted by gray CCCHHHHHEEEEEEECCCCCCCCCHHHHCCCCCCCCCEEEEEECCCCEEEEHHCHCCECCCCCCCCCEEEEEEEECCCCCCCCCEEEEEEHHHCHEEEEEEEHHCCCCEEEEEEECCCCCCCCCCC 309 309 309 309 309 305 305 305 309 309 309 309 318 310 285 282 285 283 280 282 284 289 285 286 286 287 287 287 287 285 287 294 286 294 291 289 293 293 289 289 291 293 303 310 296 297 297 297 297 183 183 183 183 183 179 179 179 183 183 183 183 192 184 159 156 159 157 154 156 158 163 159 160 160 161 161 161 161 159 161 168 160 168 165 163 167 167 163 163 165 167 177 184 170 171 171 171 171 a approximately 35% identity between GHRs of tetrapods and teleosts), the predicted secondary structures are all strikingly similar (Fig. 6a).…”

Section: Lineage-specific Features Of the Vertebrate Ghr/slrs: From Tmentioning

confidence: 99%

Evolution of Receptors for Growth Hormone and Somatolactin in Fish and Land Vertebrates: Lessons from the Lungfish and Sturgeon Orthologues

Fukamachi

Meyer

2007

J Mol Evol

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Two cognate hormones, growth hormone (GH) and somatolactin (SL), control several important physiological processes in vertebrates. Knowledge about GH and its receptor (GHR) has accumulated over the last decades. However, much less is known about SL and its receptor (SLR). SL is found only in fish (including lungfish), suggesting that it was present in the common ancestor of vertebrates, but was lost secondarily in the lineage leading to land vertebrates after the lungfish branched off. SLR was suggested to be a duplicated copy of GHR acquired only in teleosts via the fish-specific genome duplication (FSGD). This scenario (i.e., the existence of SL but not SLR in the vertebrate ancestors) is intriguing but contested. In this study, we first evaluated the plausibility of this scenario through synteny analyses and found that the loci for GHR and SLR are located in syntenic genomic positions, whereas the loci for GH and SL are not. Next, we cloned GHRs of lungfish and sturgeon, which possess SL but did not undergo the FSGD (i.e., they should not possess SLR). Their phylogenetic positions in the GHR/SLR gene tree further support the fish-specific scenario for the GHR SLR duplication. Interestingly, their sequences share greater similarity with teleost SLRs and reptilian/amphibian GHRs than with the GHRs of mammals, birds, and teleosts. On the basis of these results, we discuss the validity of the nomenclature of the teleost-specific copy of GHR as SLR and an ancestral receptor(s) for SL before the evolution of SLR during the FSGD.

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Cytoplasmic sequences of the growth hormone receptor necessary for signal transduction.

Cited by 88 publications

References 26 publications

The role of STAT proteins in growth hormone signaling

The role of STAT proteins in growth hormone signaling

Janus kinases: components of multiple signaling pathways

Evolution of Receptors for Growth Hormone and Somatolactin in Fish and Land Vertebrates: Lessons from the Lungfish and Sturgeon Orthologues

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