Cytoplasmic Localization of BAG-1 in Leukoplakia and Carcinoma of the Tongue: Correlation with p53 and C-Erbb2 in Carcinoma

Abstract

BAG-1 negativity in association with p53 and c-erbB2 positivity identified a subgroup of tongue cancer patients with an aggressive phenotype. Hence, an antiapoptotic protein, BAG-1, was found to be down-regulated in chewing-tobacco-mediated tongue carcinogenesis.

Expression of Bcl‐2 family proteins and association with clinicopathological characteristics of oral squamous cell carcinoma

“…Our results demonstrate an increase in BAG‐1 expression associated with the presence of perineural infiltration in OSCC. Some studies have suggested that analysis of BAG‐1 expression may be useful in establishing a prognosis for patients with oral SCCs and in predicting the metastatic potential of SSCs 30–33 …”

Nuclear or cytoplasmic localization of Bag-1 distinctly correlates with pathologic behavior and outcome of gastric carcinomas

“…Although several clinical studies have described Bag-1 expression in human cancers, including breast, prostate, colorectal, lung, esophagus, thyroid, endometrial, and oral cancer, the results differed between studies [8][9][10][11][12][13][14][15][16][17]. In particular, the role of Bag-1 in gastric carcinogenesis of human cells is uncertain.…”