2006
DOI: 10.1016/j.thromres.2005.03.012
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Cytoplasmic free calcium mobilization in platelets, expression of P-selectin, phosphatidylserine, and microparticle formation, measured by whole blood flow cytometry, in hypertensive patients. Effect of doxazosin GITS

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Cited by 20 publications
(12 citation statements)
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“…Labiós et al demonstrated that treatment of hypertensive patients with doxazosin leads to normalization of the kinetics of cytoplasmic cytoplasmic-free calcium, leading to a reduced release of MPs. 70 Further study is needed to confirm whether the pharmacological modulation of procoagulant MP release may improve the clinical outcomes of patients with atherothrombotic disorders.…”
Section: Calcium Channels Ions and Microparticle Formationmentioning
confidence: 99%
“…Labiós et al demonstrated that treatment of hypertensive patients with doxazosin leads to normalization of the kinetics of cytoplasmic cytoplasmic-free calcium, leading to a reduced release of MPs. 70 Further study is needed to confirm whether the pharmacological modulation of procoagulant MP release may improve the clinical outcomes of patients with atherothrombotic disorders.…”
Section: Calcium Channels Ions and Microparticle Formationmentioning
confidence: 99%
“…Cytoplasmic free calcium mobilization was evaluated according to Labiós et al 29 Briefly, CD61PE (specific monoclonal antibody to platelet GPIIIa, Pharmingen) and 250 AM fluo-3-acetoxymethyl ester (FLUO 3-AM, calcium probe, Molecular Probes, Leiden, the Netherlands) were added to the sample. The basal fluorescence intensity corresponding to FLUO 3-AM (FL1 log) was measured for 15 seconds in the platelet population identified in the gate forward scat log/side scat log as CD61-positive events.…”
Section: Cytoplasmic Free Calcium Mobilizationmentioning
confidence: 99%
“…Cytoplasmic free calcium mobilization was evaluated according to Labiós et al 16 Briefly, CD61PE (specific monoclonal antibody to platelet glycoprotein IIIa; Pharmingen, San Diego, CA) and 250 AM fluo-3-acetoxymethyl ester (FLUO 3-AM; calcium probe; Molecular Probes, Leiden, the Netherlands) were added to the sample. The basal fluorescence intensity corresponding to FLUO 3-AM (FL1 log; FLUO 3-AM-FITC) was measured for 15 seconds in the platelet population identified in the gate FS log/SS log as CD61-positive events.…”
Section: Cytoplasmic Free Calcium Mobilizationmentioning
confidence: 99%