Cytoplasmic expression of survivin is an independent predictor of poor prognosis in patients with salivary gland cancer

Stenner, Markus; Weinell, Antje; Ponert, Tobias; Hardt, Aline; Hahn, Moritz; Preuss, Simon F.; Guntinas‐Lichius, Orlando; Klußmann, Jens Peter

doi:10.1111/j.1365-2559.2010.03693.x

Cited by 17 publications

(12 citation statements)

References 24 publications

(43 reference statements)

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“…Nevertheless, most PGC are diagnosed comparatively early due to their location, and thus T1/2 tumors form a considerably amount of all PGC. According to literature, the incidence of T1/2 tumors is up to 44% of all PGC [9,15,16]. Taking into account these typical problems of a rare disease, the aim of this study was to assess the occurrence of lymph node metastasis in series of 70 patients treated for resectable early-stage PGC and evaluate the results with regard to the surgical management of PGC.…”

Section: Discussionmentioning

confidence: 99%

Occurrence of lymph node metastasis in early-stage parotid gland cancer

Stenner

Molls

Lüers

et al. 2011

Eur Arch Otorhinolaryngol

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Lymph node metastasis is one of the most important factors in therapy and prognosis for patients with parotid gland cancer. Nevertheless, the extent of the primary tumor resection and the necessity of a neck dissection still is a common issue. Since little is known about lymph node metastasis in early-stage parotid gland cancer, the purpose of the present study was to evaluate the occurrence of lymph node metastases in T1 and T2 carcinomas and its impact on local control and survival. We retrospectively analyzed 70 patients with early-stage (T1 and T2) primary parotid gland cancer. All patients were treated with parotidectomy and an ipsilateral neck dissection from 1987 to 2009. Clinicopathological and survival parameters were calculated. The median follow-up time was 51.7 months. A positive pathological lymph node stage (pN+) was found in 21.4% of patients with a significant correlation to the clinical lymph node stage (cN) (p = 0.061). There were no differences in the clinical and histopathological data between pN- and pN+ patients. In 73.3% of pN+ patients, the metastases were located intraparotideal. The incidence of occult metastases (pN+/cN-) was 17.2%. Of all patients with occult metastases, 30.0% had extraparotideal lymphatic spread. A positive lymph node stage significantly indicated a poorer 5-year overall as well as 5-year disease-free survival rate compared to pN- patients (p = 0.048; p = 0.011). We propose total parotidectomy in combination with at least a level II-III selective neck dissection in any case of early-stage parotid gland cancer.

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Section: Discussionmentioning

confidence: 99%

Occurrence of lymph node metastasis in early-stage parotid gland cancer

Stenner

Molls

Lüers

et al. 2011

Eur Arch Otorhinolaryngol

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“…However, the clinical implication of survivin expression in the prognosis of SCCHN remains controversial. Overexpression of survivin has been reported as a negative prognostic factor in SCCHN (7,37,38). It also has been reported that survivin nuclear accumulation was an independent predictor of poor survival in patients with oropharyngeal squamous cell carcinoma (SCC) (39).…”

Section: Discussionmentioning

confidence: 99%

Honokiol Radiosensitizes Squamous Cell Carcinoma of the Head and Neck by Downregulation of Survivin

Wang

Beitler

Huang

et al. 2018

Clinical Cancer Research

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Purpose Previous studies revealed diverging results regarding the role of survivin in squamous cell carcinoma of the head and neck (SCCHN).This study aimed to evaluate the clinical significance of survivin expression in SCCHN; the function of survivin in DNA damage repair following ionizing radiationtherapy (RT) in SCCHN cells; and the potential of honokiol to enhance RT through downregulation of survivin. Experimental Design Expression of survivin in SCCHN patient primary tumor tissues (n=100) was analyzed and correlated with clinical parameters. SCCHN cell lines were used to evaluate the function of survivin and the effects of honokiol on survivin expression in vitro and in vivo. Results Overexpression of survivin was significantly associated with lymph nodes metastatic status (p=0.025), worse overall survival (OS) and disease free survival (DFS) in patients receiving RT (n=65, OS: p=0.024, DFS: p=0.006) and in all patients with SCCHN (n=100, OS: p=0.002, DFS: p=0.003). In SCCHN cells, depletion of survivin led to increased DNA damage and cell death following RT, whereas overexpression of survivin increased clonogenic survival. RT induced nuclear accumulation of survivin and its molecular interaction with γ-H2AX and DNA-PKCs. Survivin specifically bound to DNA DSB sites induced by I-SceI endonuclease. Honokiol (which downregulates survivin expression) in combination with RT significantly augmented cytotoxicity in SCCHN cells with acquired radioresistance and inhibited growth in SCCHN xenograft tumors. Conclusions Survivin is a negative prognostic factor and is involved in DNA damage repair induced by RT. Targeting survivin using honokiol in combination with RT may provide novel therapeutic opportunities.

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“…Moreover, increased nuclear survivin expression correlated with negative prognostic parameters such as advanced T and N stage and was significantly associated with lower diseasespecific survival rates. Recently, Stenner et al observed a correlation of cytoplasmic survivin expression with worse survival in a cohort of salivary adenocarcinomas (n = 27) and MECs (n = 21) [33]. This group evaluated the percentage of cytoplasmic positive tumor cells without regarding the staining intensity and had a mean follow-up time of only 30 months.…”

Section: Survivinmentioning

confidence: 97%

EGFR, HER2, survivin, and loss of pSTAT3 characterize high-grade malignancy in salivary gland cancer with impact on prognosis

Ettl¹,

Stiegler²,

Zeitler³

et al. 2012

Human Pathology

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Cytoplasmic expression of survivin is an independent predictor of poor prognosis in patients with salivary gland cancer

Abstract: The correlation between cytoplasmic survivin expression and survival in salivary gland malignancies might make this an effective tool in patient follow-up, prognosis and targeted therapy in future.

Cited by 17 publications

References 24 publications

Occurrence of lymph node metastasis in early-stage parotid gland cancer

Occurrence of lymph node metastasis in early-stage parotid gland cancer

Honokiol Radiosensitizes Squamous Cell Carcinoma of the Head and Neck by Downregulation of Survivin

EGFR, HER2, survivin, and loss of pSTAT3 characterize high-grade malignancy in salivary gland cancer with impact on prognosis

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