1992
DOI: 10.1101/sqb.1992.057.01.069
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Cytoplasmic Control of Cell Adhesion

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Cited by 58 publications
(27 citation statements)
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“…the polyclonal anti-ErbB2 from DakoCytomation and a monoclonal antibody against cadherin from Transduction Laboratories (data not shown). These observations are consistent with previous studies showing localization of ErbB2 at intercellular junctions of epithelial cells (23). (Fig.…”
Section: Methodssupporting
confidence: 83%
“…the polyclonal anti-ErbB2 from DakoCytomation and a monoclonal antibody against cadherin from Transduction Laboratories (data not shown). These observations are consistent with previous studies showing localization of ErbB2 at intercellular junctions of epithelial cells (23). (Fig.…”
Section: Methodssupporting
confidence: 83%
“…However, in malignant cells EphA2 is not tyrosine-phosphorylated (17,28,34). Because of unstable cell-cell contacts in malignant cells (37)(38)(39), EphA2 cannot bind to its membrane-anchored ligand ephrinA1 (28). Notably, the E-cadherin adhesion protein is a powerful suppressor of metastasis, and E-cadherin has been shown to regulate the ability of EphA2 to bind its ligand (40).…”
Section: Discussionmentioning
confidence: 99%
“…The cooperative model for the assembly of the junctional plaque from soluble cytoplasmic components (Kreis et al, 1984;Geiger et al, 1990Geiger et al, , 1992a would predict that a decrease in vinculin expression may result in an inefficient assembly of adhesion plaque molecules, leading to decreased adhesion, and this in turn will result in increased motility. In contrast, overexpression of vinculin may facilitate a cooperative and more efficient recruitment and assembly of AJs, and will lead to increased adhesion and decreased motility.…”
Section: Discussionmentioning
confidence: 99%