Cytoplasmic Ca²⁺Dynamics under the Interplay between the Different IP₃R Gating Models and the Plasma Membrane Ca²⁺Influx

Abstract

The cytoplasmic Ca 2+ oscillations are investigated under the effect of CRAC channels in non-excitable cells (especially in T cells). The oscillatory Ca 2+ signals can be modulated as the amplitude-, frequency-and mixed amplitude-frequency modulation modes dependent on the different IP3R gating models. Bifurcation analyses show that Ca 2+ signals in the single positive feedback loop model is a mixed modulation mode. In contrast, Ca 2+ signals in the Mak-McBride-Foskett model demonstrates approximately the frequency modulation mode only with slight amplitude shifts.