Cytophagic histiocytic panniculitis—a syndrome associated with benign and malignant panniculitis: Case comparison and review of the literature

Craig, Arthur J.; Cualing, Hernani; Thomas, G. E.; Lamerson, Cindy L.; Smith, R. Neal

doi:10.1016/s0190-9622(98)70044-1

Cited by 104 publications

(102 citation statements)

References 60 publications

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“…In cases with cytophagic histiocytic panniculitis or hemophagocytic syndrome, histiocytes phagocytizing red and white blood cells are present (Fig 4). 26,29,32,33 Immunophenotype: The neoplastic cells are usually positive for CD3, CD2, CD56, and cytotoxic proteins, (TIA-1, granzyme B, and perforin), 26,28,33 and negative for CD4, CD8, β-F1, and CD5.…”

Section: Pattern Of Infiltrationmentioning

confidence: 99%

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Classification and Treatment of Rare and Aggressive Types of Peripheral T-Cell/Natural Killer-Cell Lymphomas of the Skin

2007

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Section: Pattern Of Infiltrationmentioning

confidence: 99%

“…24,27,28 The indolent form of cytophagic histiocytic panniculitis appears similar to SPTCL. 29,30 Pattern of Infiltration: A dense collection of cells is largely confined to the subcutaneous fat (Fig 1). The lymphoid cells characteristically rim individual adipocytes in a "wreath-like"manner (Fig 2).…”

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confidence: 99%

Classification and Treatment of Rare and Aggressive Types of Peripheral T-Cell/Natural Killer-Cell Lymphomas of the Skin

2007

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“…It may be an isolated skin disease or associated with nonmalignant conditions, such as infections or connective tissue disorders as well as with malignancies, including subcutaneous panniculitis-like T-cell lymphoma (SPTCL). 1 It is clinically important to be able to distinguish between these 2 conditions to identify appropriate treatment: benign CHP often improves with cyclosporine A (CSA) and prednisone, whereas most cases of SPTCL may require a more aggressive therapy. We report the clinical course and the histopathologic and immunohistochemical findings in skin biopsies for 2 children who presented with clonal CHP and SPTCL aspect preceding MAS.…”

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confidence: 99%

Clonal Cytophagic Histiocytic Panniculitis in Children May Be Cured by Cyclosporine A

Bader-Meunier

Fraïtag

Janssen³

et al. 2013

Pediatrics

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Cytophagic histiocytic panniculitis (CHP) is a rare panniculitis in childhood, associated either with nonmalignant conditions or with subcutaneous panniculitis-like T-cell lymphoma (SPTCL), and often also associated with macrophage activation syndrome (MAS). Discriminating between these 2 conditions is therapeutically important because nonmalignant CHP often improves under cyclosporine and prednisone, whereas most cases of SPLT may be best treated with more aggressive therapy. We report the cases of a 6-month-old boy and a 16-month-old girl who, after viral infection, developed multiple infiltrating skin nodules on the limbs and face, associated with MAS. Histopathologic findings for skin biopsy specimens revealed CHP associated with heavily cellular lobular panniculitis. Hemophagocytosis and immunohistochemical staining features were consistent with typical characteristics of in situ MAS in adipose tissue: the lymphocytes were mostly TCD8+ cells with an activated phenotype (human leukocyte antigen (HLA) -DR+) and expressed interferon-g; CD68+ macrophages expressed tumor necrosis factor-a and interleukin-6. A monoclonal rearrangement of the T-cell receptor g gene was present in skin tissue but not in peripheral blood or bone marrow lymphocytes. Cyclosporine A treatment resulted in the complete remission of cutaneous and systemic manifestations in both patients for 66 and 29 months, respectively. This report suggests that the diagnosis of a reactive T-cell lymphoproliferation should be the treatment of choice in young children with severe CHP, even if there is a SPTCL-like aspect with an in situ T-cell clonality. It also suggests that CSA is the optimal treatment of this condition and postulates the possible pathologic process underlying this efficacy. Pediatrics 2013;132:e545-e549

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“…Although SPTCLs are usually negative for EBV [3,18,65], it has been found to occur in the Asian population [66]. SPTCL associated with an EBV infection has an aggressive biologic behavior [67,68]. Staining for EBV may be a valuable adjunct in differentiating SPTCL from extranodal natural killer (NK)/T-cell lymphoma, nasal type, which may sometimes also present with prominent subcutaneous involvement [3,65].…”

Section: Discussionmentioning

confidence: 99%

Subcutaneous Panniculitis-like T-cell Lymphoma: Review of Therapies

S¹,

Chaudhari²

2015

Intern Med

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Subcutaneous Panniculitis-like T-cell Lymphoma (SPTCL) is a rare subtype of cutaneous T-cell lymphoma derived from alpha/beta cytotoxic T-cells. It is known to follow an indolent course with a favorable prognosis. We review current therapies used to treat this rare entity in order to increase awareness about possible options. No standardized therapy for SPTL currently exists. Local radiotherapy for indolent local disease has been found successful. For indolent disease with a more generalized distribution, immunosuppressive agents as well as lowdose chemotherapy may be used. For aggressive presentations, combination chemotherapy, anthracycline-based regimens, fludarabine-based regimens, and rarely high-dose chemotherapy followed by hematopoietic stem cell transplant (SCT) with moderate success. By being aware of possible therapeutic options, a physician can recommend the most appropriate treatment for the individual.

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Cytophagic histiocytic panniculitis—a syndrome associated with benign and malignant panniculitis: Case comparison and review of the literature

Cited by 104 publications

References 60 publications

Classification and Treatment of Rare and Aggressive Types of Peripheral T-Cell/Natural Killer-Cell Lymphomas of the Skin

Classification and Treatment of Rare and Aggressive Types of Peripheral T-Cell/Natural Killer-Cell Lymphomas of the Skin

Clonal Cytophagic Histiocytic Panniculitis in Children May Be Cured by Cyclosporine A

Subcutaneous Panniculitis-like T-cell Lymphoma: Review of Therapies

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