Cytopathologic and Neurochemical Correlates of Progression to Motor/Cognitive Impairment in SIV-lnfected Rhesus Monkeys

Rausch, Dianne M.; Heyes, Melviyn P.; Murray, Elisabeth A.; Lendvay, Judit; Sharer, Leroy R.; Ward, Jerrold M.; Rehm, Sabine; Nöhr, Donatus; Weihe, Eberhard; Eiden, Lee E.

doi:10.1097/00005072-199403000-00008

Cited by 74 publications

(53 citation statements)

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“…Pancreatic specimens were also obtained from five rhesus monkeys (Rausch et al 1994). The specificity and sensitivity of the VMAT1 and VMAT2 antibodies and the VMAT1 and VMAT2 antisense probes were tested in various human and monkey tissues, including adrenal medulla, stomach, small intestine, one gastric ECL cell tumor, and two intestinal EC cell tumors.…”

Section: Origin Of Tissuesmentioning

confidence: 99%

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Expression of the Two Isoforms of the Vesicular Monoamine Transporter (VMAT1 and VMAT2) in the Endocrine Pancreas and Pancreatic Endocrine Tumors

Anlauf

Eissele

Schäfer

et al. 2003

J Histochem Cytochem.

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109

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S U M M A R YThe uptake of monoamines into the secretory granules of monoamine-storing neuroendocrine cells is mediated by vesicular monoamine transporter protein 1 or 2 (VMAT1 or VMAT2). This study analyzed the expression of VMAT1 and VMAT2 in endocrine cells of normal human and monkey pancreas. The expression of VMAT1 and VMAT2 was also examined in infants with hyperinsulinemic hypoglycemia and in adults with pancreatic endocrine tumors (PETs). Using immunohistochemistry (IHC) and in situ hybridization (ISH), we demonstrated the mutually exclusive expression of VMAT1 in endocrine cells of the duct system and of VMAT2 in many cells of the islets of Langerhans. By confocal laser scanning microscopy, VMAT1-positive cells were identified as enterochromaffin (EC) cells and VMAT2-positive cells as ␤ -cells. In PETs, VMAT1 was found exclusively in all serotonin-containing tumors. In contrast, VMAT2 expression was lost in many insulinomas, independent of their biological behavior. VMAT2 was expressed by some non-insulin-producing tumors. The mutually exclusive expression of VMAT1 in EC cells and of VMAT2 in ␤ -cells suggests that both cell types store monoamines. Monoamine storage mediated by VMAT1 in EC cells is apparently maintained in EC cell tumors. In contrast, many insulinomas appear to lose their ability to accumulate monoamines via VMAT2. (J Histochem

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Section: Origin Of Tissuesmentioning

confidence: 99%

“…The monkey tissues were perfused with 4% formaldehyde/PBS before postfixation in Bouin-Hollande for 24-48 hrs as described previously (Rausch et al 1994).…”

Section: Tissue Preparationmentioning

confidence: 99%

Expression of the Two Isoforms of the Vesicular Monoamine Transporter (VMAT1 and VMAT2) in the Endocrine Pancreas and Pancreatic Endocrine Tumors

Anlauf

Eissele

Schäfer

et al. 2003

J Histochem Cytochem.

Self Cite

109

101

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“…The monkey tissues were perfused with 4% formaldehyde/PBS before postfixation in Bouin-Hollande for 24-48 hr, as described previously (Rausch et al 1994).…”

Section: Tissue Collection and Preparationmentioning

confidence: 99%

The Vesicular Monoamine Transporter 2 (VMAT2) Is Expressed by Normal and Tumor Cutaneous Mast Cells and Langerhans Cells of the Skin but Is Absent from Langerhans Cell Histiocytosis

Anlauf

Schäfer

Depboylu

et al. 2004

J Histochem Cytochem.

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S U M M A R YMonoamine storage in secretory granules is mediated by the vesicular monoamine transporters 1 and 2 (VMAT1 and VMAT2). The aim of our study was to identify monoamine-handling normal and neoplastic inflammatory cells in the skin by their expression of VMAT1 and VMAT2. Normal skin from various parts of the body, as well as 21 cases of cutaneous mastocytosis and 10 cases of cutaneous Langerhans cell histiocytosis were analyzed by immunohistochemistry, radioactive in situ hybridization, and doublefluorescence confocal microscopy. VMAT2-positive cells in the subepidermal layer were

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“…We found that Quin-IR in the controls also increased to some extent over (35)(36)(37). Quin has been reported to be increased in the CSF in response to other viral infections including HIV-1 and SIV (8)(9)(10); however, the cellular origin of Quin is unclear. Based on biochemical studies, MOs have been hypothesized to be a potential source of Quin (11,38).…”

Section: Resultsmentioning

confidence: 70%

“…Recently, this activation of the kynurenine pathway during inflammation was shown to be associated with increased concentrations of Quin in the blood and cerebrospinal fluid (CSF) (7). Also, in selected cases such as infections with human and simian immunodeficiency viruses (HIV-I and SIV), Quin increase was correlated with cognitive impairment and/or motor dysfunction (8)(9)(10). Additionally, IFN-,y treatment stimulated Quin synthesis from tryptophan in a MO-enriched preparation from human peripheral blood (11).…”

Section: Infection Of Mos By Human T-cell Lymphotropic Virus Type Imentioning

confidence: 99%

Immunocytochemical localization of the endogenous neuroexcitotoxin quinolinate in human peripheral blood monocytes/macrophages and the effect of human T-cell lymphotropic virus type I infection.

Venkateshan¹,

Narayanan²,

Espey³

et al. 1996

Proc. Natl. Acad. Sci. U.S.A.

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Immunocytochemical localization of the endogenous neuroexcitotoxin quinolinate in human peripheral blood monocytes/macrophages and the effect of human T-cell lymphotropic virus type I infection Contributed by D. Carleton Gajdusek October 19, 1995 ABSTRACT Quinolinate (Quin), a metabolite in the kynurenine pathway of tryptophan degradation and a neurotoxin that appears to act through the N-methyl-D-aspartate receptor system, was localized in cultured human peripheral blood

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Cytopathologic and Neurochemical Correlates of Progression to Motor/Cognitive Impairment in SIV-lnfected Rhesus Monkeys

Cited by 74 publications

References 0 publications

Expression of the Two Isoforms of the Vesicular Monoamine Transporter (VMAT1 and VMAT2) in the Endocrine Pancreas and Pancreatic Endocrine Tumors

Expression of the Two Isoforms of the Vesicular Monoamine Transporter (VMAT1 and VMAT2) in the Endocrine Pancreas and Pancreatic Endocrine Tumors

The Vesicular Monoamine Transporter 2 (VMAT2) Is Expressed by Normal and Tumor Cutaneous Mast Cells and Langerhans Cells of the Skin but Is Absent from Langerhans Cell Histiocytosis

Immunocytochemical localization of the endogenous neuroexcitotoxin quinolinate in human peripheral blood monocytes/macrophages and the effect of human T-cell lymphotropic virus type I infection.

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