Cytomorphometric Analysis of Inflammation Dynamics in the Periodontium Following the Use of Fixed Dental Prostheses

Heboyan, Artak; Syed, Azeem Ul Yaqin; Rokaya, Dinesh; Cooper, Paul R.; Manrikyan, Mikael; Markaryan, Marina

doi:10.3390/molecules25204650

Cited by 29 publications

(33 citation statements)

References 34 publications

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“…Cytomorphometric analysis is a cytological study that may enable the selection of the most appropriate prostheses for patients with existing periodontal pathologies [ 38 , 39 ]. Recently, Heboyan et al [ 39 ] assessed the inflammation dynamics using a cytomorphometric analysis of the periodontium before and after the use of fixed dental prostheses and reported no significant changes in the parameters among patients with a healthy periodontium, before and after prosthetic treatment and regardless of the prosthesis type used. In all study groups, there was a statistically significant increase ( p < 0.05) in the oral epithelial cell counts and a statistically significant decrease ( p < 0.05) in the PMN count following the insertion of the fixed prostheses.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of Periodontal Tissues in Prosthetic Treatment with Fixed Dental Prostheses

et al. 2021

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The objective of the present study was to investigate the effects of various types of fixed prostheses on periodontal tissues and explore the association of gingival biotype and gum recession in relation to prosthesis types. The study participants (N = 95) were divided into three groups based on the type of dental prosthesis: Group-I: cobalt-chrome (Co-Cr) ceramic prosthesis fabricated by the conventional method (n = 35); Group-II: consisted of patients with Co-Cr ceramic prostheses fabricated by a computer-aided design and computer aided manufacturing (CAD/CAM) technique (n = 30); and Group-III: zirconia-based prostheses fabricated by the CAD/CAM technique (n = 30). Following the use of prostheses, periodontal examinations were performed using the Community Periodontal Index (CPI) and Modified Approximal Plaque Index (MAPI). In addition, the gingival biotype was examined using a probe transparency method. The Statistical Package for the Social Sciences (SPSS), Version 20 (IBM Company, Chicago, IL, USA), was used to analyze the results, and the significance level was set at p = 0.05. It showed the MAPI results after the use of prosthetic rehabilitation for 12 months of periodontitis in 87.9% ± 15.4 of patients in Group-I, in 80.6% ± 17.97 in those in Group-II, and in 62.5% ± 21.4 in those in Group-III (p < 0.01). The CPI index results indicated a high prevalence of periodontal disease in all groups. The number of people with healthy periodontium constituted 17.1% of patients in Group-I, 24.2% in Group-II, and 37.1% in Group-III. Our study concluded that prosthetic treatment with periodontal diseases showed better outcomes while using dental prostheses fabricated by the CAD/CAM technique compared to the conventionally fabricated dental prostheses. The thin gingival biotype is more often associated with gingival recession than the thick biotype.

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Section: Discussionmentioning

confidence: 99%

Characteristics of Periodontal Tissues in Prosthetic Treatment with Fixed Dental Prostheses

et al. 2021

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“…In this type of prosthesis, inflammatory processes in periodontium do not occur, quickly improving the marginal fit and reducing the risk of formation of dental biofilm. In addition, zirconium dioxide is biocompatible with the mucous membranes and tissues of the oral cavity [ 8 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

“…Heboyan et al [ 8 ] studied inflammation dynamics using cytomorphometric analysis of the periodontium before and after the use of fixed dental prostheses using the conventional method (C/M/CoCr), cobalt-chrome metal-ceramic prostheses using the CAD/CAM technique (C/C/CoCr), and zirconia-based ceramic prostheses using the CAD/CAM technique (C/C/Zr) among subjects with gingivitis and periodontitis. They found that regardless of prostheses type used, no significant change in the parameters was identified among patients with a healthy periodontium, before and after prosthetic treatment.…”

Section: Discussionmentioning

confidence: 99%

“…After 30 s of maintenance in the sulcus, the Periopaper was removed. The paper strips were stored in vials and transported to the laboratory using Hicultur Transport swab Himedia in Amies Charcoal medium (Thermo Fisher Scientific, Invitrogen BioServices, Mumbai, India) [ 8 , 29 ].…”

Section: Methodsmentioning

confidence: 99%

“…Various oral microbial species present in the biofilm attached to oral tissues and materials are mainly associated with the inflammatory reaction in the oral tissues. The extent and severity of inflammation vary depending on the properties of the biomaterials used for prosthodontic constructions and the nature of the oral microbial species present in the biofilm [ 7 , 8 ]. The pathological bacterial species found in various oral diseases are also present in normal oral flora, having complex interactions with the dynamic oral environment and other bacterial species.…”

Section: Introductionmentioning

confidence: 99%

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Bacteriological Evaluation of Gingival Crevicular Fluid in Teeth Restored Using Fixed Dental Prostheses: An In Vivo Study

Heboyan

Manrikyan

Zafar

et al. 2021

IJMS

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The present in vivo study determined the microbiological counts of the gingival crevicular fluid (GCF) among patients with fixed dental prostheses fabricated using three different techniques. A total of 129 subjects were divided into three study groups: first, cobalt-chrome-based, metal-ceramic prostheses fabricated by the conventional method (MC, n = 35); the second group consisted of cobalt-chrome-based, metal-ceramic prostheses fabricated by the computer-aided design and computer-aided manufacturing (CAD/CAM) technique (CC-MC, n = 35); the third group comprised zirconia-based ceramic prostheses fabricated using the CAD/CAM technique (CC-Zr, n = 35). The control consisted of 24 patients using prostheses fabricated with either MC, CC-MC, or CC-Zr. The GCF was obtained from the subjects before treatment, and 6 and 12 months after the prosthetic treatment. Bacteriological and bacterioscopic analysis of the GCF was performed to analyze the patients’ GCF. The data were analyzed using SPSS V20 (IBM Company, Chicago, IL, USA). The number of microorganisms of the gingival crevicular fluid in all groups at 12 months of prosthetic treatment reduced dramatically compared with the data obtained before prosthetic treatment. Inflammatory processes in the periodontium occurred slowly in the case of zirconium oxide-based ceramic constructions due to their biocompatibility with the mucous membranes and tissues of the oral cavity as well as a reduced risk of dental biofilm formation. This should be considered by dentists and prosthodontists when choosing restoration materials for subjects with periodontal pathology.

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3D-Printed Biomaterials in Biomedical Application

Rokaya

Kongkiatkamon

Heboyan

et al. 2022

Functional Biomaterials

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Cytomorphometric Analysis of Inflammation Dynamics in the Periodontium Following the Use of Fixed Dental Prostheses

Cited by 29 publications

References 34 publications

Characteristics of Periodontal Tissues in Prosthetic Treatment with Fixed Dental Prostheses

Characteristics of Periodontal Tissues in Prosthetic Treatment with Fixed Dental Prostheses

Bacteriological Evaluation of Gingival Crevicular Fluid in Teeth Restored Using Fixed Dental Prostheses: An In Vivo Study

3D-Printed Biomaterials in Biomedical Application

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