Cytomorphologic Features of Diffuse Sclerosing Variant of Papillary Carcinoma of the Thyroid

Kumarasinghe, Marian Priyanthi

doi:10.1159/000331981

Cited by 28 publications

(25 citation statements)

References 6 publications

(3 reference statements)

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“…Previous reports have described squamous cells in 40-100% of FNACs. [10][11][12] The discrepancy between the present and previous findings may reflect the fact that the prior investigations were case studies showing typical cytologic features. Metaplastic squamous cells in this study were located mainly in central fibrotic and sclerotic areas showing focal involvement rather than in widespread and diffuse patterns, which was another reason for the low identification rate of squamous cells in FNAC.…”

Section: Discussioncontrasting

confidence: 99%

“…Sensitivity, specificity, positive predictive rate, and negative predictive rate of cytologic parameters in DSPC Cytologic features used to diagnose DSPC typically include numerous psammoma bodies and lymphocytes, squamous cells, absent colloid, and epithelial cells showing classical features of papillary carcinoma such as nuclear grooves and nuclear inclusion. [10][11][12] In the present study, only one (6.2%) case showed all of these features in FNAC. The previous studies were case reports of typical cases, not a cytohistological analysis like this study, which may well account for the dichotomous findings.…”

Section: Discussioncontrasting

confidence: 53%

“…Presently, nine (56.2%) cases showed lymphocytic thyroiditis on histology but, of these, four cases (25.0%) demonstrated lymphocytes in FNAC; these observations differ from previous studies showing that most cases of DSPC display lymphocytes in FNAC. [10][11][12] However, only nine (56.2%) cases demonstrated lymphocytic thyroiditis on histology. Therefore, lymphocytic infiltration was not a frequently identified feature in this study.…”

Section: Discussionmentioning

confidence: 96%

“…[10][11][12] However, out of the six cases lacking psammoma bodies, three were diagnosed as suspicious cytology cases due to low cellularity, indicating that the possibility of identifying psammoma bodies in adequate FNAC could be increased. In this study, five (31.2%) cases showed colloid material in follicles of papillary carcinoma, which presented a follicular pattern on histology slides.…”

Section: Discussionmentioning

confidence: 99%

“…[7][8][9] However, the cytologic features of DSPC have only been described in a few case reports. [10][11][12] The purpose of this study was to investigate the cytomorphologic characteristics of DSPC and identify cytologic features, with the aim of improving the preoperative diagnosis of DSPC.…”

Section: 4mentioning

confidence: 99%

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Cytologic Features of Diffuse Sclerosing Variant of Papillary Carcinoma - Cytohistopathologic Analysis of 16 Cases -

et al. 2009

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Background :The exact preoperative diagnosis of diffuse sclerosing papillary carcinoma (DSPC) is required for aggressive surgical treatment due to its extended involvement with thyroid and neck lymph nodes. The present study investigated the cytomorphologic characteristics of DSPC and identified cytologic features for preoperative diagnosis of DSPC. Methods : A retrospective review of cytologic and histologic features of 16 patients diagnosed with DSPC after thyroidectomy and underwent preoperative fine needle aspiration cytology (FNAC) was performed. Results : Prominent psammoma bodies were observed in 16 (100%) and 10 (62.5%) cases of histology and FNAC, respectively. Lymphocytes were observed in nine (56.2%) and four (25.0%) cases, and squamous cells were noted in seven cases (43.7%) and one case (6.2%) on histology and FNAC, respectively. Nuclear grooves and inclusions, which are characteristics of papillary carcinoma, were observed in FNAC and histology slides in all 16 cases. Conclusions : DSPC displays prominent psammoma bodies and characteristic nuclear features of papillary carcinoma such as nuclear groove and inclusion in FNAC. However, the preoperative diagnosis of DSPC using only FNAC could be difficult due to the absence of other characteristic features such as lymphocytes and metaplastic squamous cells.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 53%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: 4mentioning

confidence: 99%

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Cytologic Features of Diffuse Sclerosing Variant of Papillary Carcinoma - Cytohistopathologic Analysis of 16 Cases -

et al. 2009

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Thyroid

2017

Cytopathology of the Head and Neck

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Cytologic features of aggressive variants of follicular‐derived thyroid carcinoma

Rossi

Faquin

Pantanowitz

2019

Cancer Cytopathology

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Certain carcinomas of the thyroid gland behave aggressively resulting in increased patient morbidity and poor patient prognosis. The diagnosis of these aggressive thyroid cancer subtypes is sometimes challenging and subject to increased interobserver variability. This review deals with the cytological features of such tumors including aggressive variants of papillary thyroid carcinoma, poorly differentiated thyroid carcinoma, and anaplastic thyroid carcinoma. These malignancies fall into 2 groups based on their cytomorphology: those that exhibit distinct microscopic features (eg, nuclear findings typical of classical papillary thyroid carcinoma or marked anaplasia) and those that present with more subtle cytologic features (eg, nuclear pseudostratification, “soap bubble” nuclei, supranuclear or subnuclear cytoplasmic vacuoles, rosette‐like structures, hobnail cells). We review the literature regarding these aggressive thyroid cancers and highlight important phenotypic characteristics that can be useful for their diagnosis based on fine needle aspiration.

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Cytomorphologic Features of Diffuse Sclerosing Variant of Papillary Carcinoma of the Thyroid

Cited by 28 publications

References 6 publications

Cytologic Features of Diffuse Sclerosing Variant of Papillary Carcinoma - Cytohistopathologic Analysis of 16 Cases -

Cytologic Features of Diffuse Sclerosing Variant of Papillary Carcinoma - Cytohistopathologic Analysis of 16 Cases -

Thyroid

Cytologic features of aggressive variants of follicular‐derived thyroid carcinoma

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