Cytomimetic Biomaterials. 4. In-Situ Photopolymerization of Phospholipids on an Alkylated Surface

Orban, Janine M.; Faucher, Keith M.; Dluhy, Richard A.; Chaikof, Elliot L.

doi:10.1021/ma9915780

Cited by 57 publications

(61 citation statements)

References 46 publications

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“…Surface modification typically follows two approaches. The first one is to generate hydroxylterminated monolayers [195,198,199] and the second one is to utilize the chemical or physical adsorption of phospholipids or phospholipid derivatives on alkylsilane monolayers [196,197,[200][201][202][203]. Protein adsorption and cell adhesion are reduced on the phosphorylcholine-assembled surfaces.…”

Section: Biochemical Modification Of Titanium and Titanium Alloysmentioning

confidence: 99%

Surface modification of titanium, titanium alloys, and related materials for biomedical applications

Liu

Chu

Ding

2004

Materials Science and Engineering: R: Reports

3,032

1,477

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Titanium and titanium alloys are widely used in biomedical devices and components, especially as hard tissue replacements as well as in cardiac and cardiovascular applications, because of their desirable properties, such as relatively low modulus, good fatigue strength, formability, machinability, corrosion resistance, and biocompatibility. However, titanium and its alloys cannot meet all of the clinical requirements. Therefore, in order to improve the biological, chemical, and mechanical properties, surface modification is often performed. This article reviews the various surface modification technologies pertaining to titanium and titanium alloys including mechanical treatment, thermal spraying, sol-gel, chemical and electrochemical treatment, and ion implantation from the perspective of biomedical engineering. Recent work has shown that the wear resistance, corrosion resistance, and biological properties of titanium and titanium alloys can be improved selectively using the appropriate surface treatment techniques while the desirable bulk attributes of the materials are retained. The proper surface treatment expands the use of titanium and titanium alloys in the biomedical fields. Some of the recent applications are also discussed in this paper. #

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Section: Biochemical Modification Of Titanium and Titanium Alloysmentioning

confidence: 99%

Surface modification of titanium, titanium alloys, and related materials for biomedical applications

Liu

Chu

Ding

2004

Materials Science and Engineering: R: Reports

3,032

1,477

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“…We have previously reported the in situ polymerization of phospholipids on self-assembled monolayers of octadecyl mercaptan bound to gold [25], octadecyl trichlorosilane on glass [16,26], and on an amphiphilic polymer cushion [27,28]. Moreover, we have demonstrated the ability to functionalize these surfaces by creating glycocalyx-mimetic surfaces [29] and protein C activating surfaces by the functional reconstitution of thrombomodulin [30][31][32].…”

Section: Introductionmentioning

confidence: 96%

In vivo biocompatibility and stability of a substrate-supported polymerizable membrane-mimetic film

et al. 2007

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“…Several studies have described preparation of asymmetric bilayers using polymerizable lipids in an attempt to achieve stabilization through monolayer polymerization 29–38. For example, Chaikof and coworkers formed HBMs on several modified surfaces, including alkyl-terminated SAMs, using monoacrylate-functionalized lipids 29, 35–38.…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of asymmetric planar supported bilayers composed of poly(bis-sorbylphosphatidylcholine) on n-octadecyltrichlorosilane SAMs

Ratnayaka

Wysocki

Saavedra

2008

Journal of Colloid and Interface Science

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Planar supported lipid bilayers (PSLBs) have been widely studied as biomembrane models and biosensor scaffolds. For technological applications, a major limitation of PSLBs composed of fluid lipids is that the bilayer structure is readily disrupted when exposed to chemical, mechanical, and thermal stresses. A number of asymmetric supported bilayer structures, such as the hybrid bilayer membrane (HBM) and the tethered bilayer lipid membrane (tBLM), have been created as an alternative to symmetric PSLBs. In both HBMs and tBLMs, the inner monolayer is covalently attached to the substrate while the outer monolayer is typically composed of a fluid lipid. Here we address if cross-linking polymerization of the lipids in the outer monolayer of an asymmetric supported bilayer can achieve the high degree of stability observed previously for symmetric PSLBs in which both monolayers are cross-linked [Ross, E. E., et al., Langmuir 2003, 19, 1752-1765. To explore this issue, HBMs composed of an outer monolayer of a cross-linkable lipid, bisSorbylphosphatidylcholine (bis-SorbPC), and an inner SAM were prepared and characterized. Several experimental conditions were varied: vesicle fusion time, polymerization method, and polymerization time and temperature. Under most conditions, bis-SorbPC cross-linking stabilized the HBM such that its bilayer structure was largely preserved after drying; however these films invariably contained sub-micron scale defects that exposed the hydrophobic core of the HBM. The defects appear to be caused by desorption of low molecular weight oligomers when the film is removed from water, rinsed, and dried. In contrast, poly(bis-SorbPC) PSLBs prepared under similar conditions by Ross et al. were nearly defect free. This comparison shows that formation of a crosslinked network in the outer leaflet of an asymmetric supported bilayer is insufficient to prevent lipid desorption; inter-leaflet covalent linking appears to be necessary to create supported poly(lipid) assemblies that are impervious to repeated drying and rehydration. The difference in stability is attributed to inter-leaflet cross-linking between monolayers which can form in symmetric bis-SorbPC PSLBs.

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Cytomimetic Biomaterials. 4. In-Situ Photopolymerization of Phospholipids on an Alkylated Surface

Cited by 57 publications

References 46 publications

Surface modification of titanium, titanium alloys, and related materials for biomedical applications

Surface modification of titanium, titanium alloys, and related materials for biomedical applications

In vivo biocompatibility and stability of a substrate-supported polymerizable membrane-mimetic film

Preparation and characterization of asymmetric planar supported bilayers composed of poly(bis-sorbylphosphatidylcholine) on n-octadecyltrichlorosilane SAMs

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