Cytomegalovirus seroprevalence, infection, and disease in Chinese thoracic organ transplant recipients: a retrospective cohort study

Abstract

Background Cytomegalovirus (CMV) infection is a leading cause of morbidity and mortality after transplantation. This study aimed to investigate CMV seroprevalence, infection, and disease in Chinese thoracic organ transplant recipients. Methods The clinical data of the patients who underwent lung and/or heart transplantation between January 2015 and October 2020 were retrospectively collected from four transplantation centers in China. Results A total of 308 patients were analyzed. The CMV serostatus was donor positive (D+) recipient negative (R−) in 19 (6.17%) patients, D+/R+ in 233 (75.65%), D−/R+ in 36 (11.69%), and D−/R− in 20 (6.50%). CMV DNAemia was detected in 52.3% of the patients and tissue-invasive CMV disease was diagnosed in 16.2% of the patients. Only 31.8% of the patients adhered to the postdischarge valganciclovir therapy. The D+/R− serostatus (odds ratio [OR]: 18.32; 95% confidence interval [CI]:1.80-188.68), no valganciclovir prophylaxis (OR: 2.64; 95% CI: 1.05–6.64), and higher doses of rabbit anti-human thymocyte globulin (> 2 mg/kg) (OR: 4.25; 95% CI: 1.92–9.42) were risk factors of CMV disease. Conclusion CMV seroprevalence was high in Chinese thoracic organ transplant donors and recipients. The low adherence rate to the postdischarge CMV prophylaxis therapy in Chinese patients is still an unresolved issue.

Prevalent Complications in Heart Transplantation: A Retrospective Cohort Analysis

“…Furthermore, CMV infection is one of the most common opportunistic infections in these patients. A study carried out in China, with 308 post-pulmonary HTx patients, detected CMV in 52.3% of the sample 17 , while this study showed 44.9% and a median time of 39 days, that is, 50% of the population presented CMV within 39 days post-HTx.…”

Complicações Prevalentes no Transplante Cardíaco: Uma Análise de Coorte Retrospectiva

“…Além disso, uma das infecções oportunistas mais comuns nesses pacientes é a infecção por CMV. Um estudo realizado na China, com 308 pacientes pós-TxC e pulmonar, detectou CMV em 52,3% da amostra 17 , enquanto este estudo apresentou 44,9% e, ainda, tempo mediano de 39 dias, ou seja, 50% da população apresentou CMV em 39 dias pós-TxC.…”

Differentiation between lung allograft rejection and infection using donor-derived cell-free DNA and pathogen detection by metagenomic next-generation sequencing

“…Pathogen evidence was based on comprehensive microorganism detection methods, which included mNGS, culture, and smear. Furthermore, the diagnosis of Cytomegalovirus (CMV)infection was made based on established guidelines and our prior study [ 18 , 19 ].…”