Cytomegalovirus Seroprevalence Among Children and Adolescents in Germany: Data From the German Health Interview and Examination Survey for Children and Adolescents (KiGGS), 2003–2006

Voigt, Sebastian; Rosario, Angelika Schaffrath; Mankertz, Annette

doi:10.1093/ofid/ofv193

Cited by 46 publications

(45 citation statements)

References 37 publications

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“…This number is within the wide range of the previously published data for population groups in Europe of 30.4 to 89.7%. [9,11,[13][14][15][16][17][18][19]. The slight decrease of 0.77% from the previous decade (1998 to 2008) was not statistically significant (p = 0.0881).…”

Section: Discussionmentioning

confidence: 84%

“…In our youngest patients, below the age of 20 years, and in the age group 30-39 years, however, the trend halted or even reversed. In the youngest patients, this might be associated with more children below the age of 3 years attending daycare, where the exposure to potentially infectious toddlers as a source of infection is increased, a known factor associated with CMV seropositivity in Germany [15]. Notably, from 2006 to 2017, the percentage of children below the age of 3 years attending day care in Germany increased from 13.6 to 33.1% [22].…”

Section: Discussionmentioning

confidence: 99%

“…CMV seroprevalence increased with age in both genders. Risk factors for higher seroprevalence included migration background, place of birth other than Germany, having attended daycare, and having younger siblings [15]. In a study in the adult population of Germany, sera collected throughout Germany in 1998, published 2018, the overall CMV seroprevalence was 56.7% and also increased with age.…”

Section: Introductionmentioning

confidence: 99%

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Thirty years of CMV seroprevalence—a longitudinal analysis in a German university hospital

Hoehl

Berger

Ciesek

et al. 2020

Eur J Clin Microbiol Infect Dis

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Human cytomegalovirus (CMV) is a significant cause of morbidity and mortality in patient groups at risk. We have previously shown that the anti-CMV IgG seroprevalence in an urban region of Germany has changed over the last decades. Overall, a decline from 63.7 to 57.25% had been observed between 1988-1997 and 1998-2008 (p < 0,001). Here, we continuously follow the trends to the most recent decade 2009 to 2018. In a retrospective analysis, we determined the seroprevalence of CMV IgG antibodies in our patient cohort, stratified by gender and selected groups at risk (e.g., patients with HIV infection; women of childbearing age). The overall prevalence of anti-CMV IgG non-significantly declined further from 57.25% in 1998-2008 to 56.48% in 2009-2018 (p = 0.881). Looking at gender differences, overall CMV seroprevalence in males declined to 52.82% (from 55.54% in 1998-2008; p = 0.0254), while it non-significantly increased in females to 59.80%. The high seroprevalence in patients with a known HIV infection further increased from 87.46% in 1998-2008 to 92.93% in the current period (p = 0.9999). In women of childbearing age, no significant changes over the last three decades could be observed. The CMV seroprevalence in oncological patients was determined to be 60.64%. Overall, the former significant decline of CMV seroprevalence between the

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Thirty years of CMV seroprevalence—a longitudinal analysis in a German university hospital

Hoehl

Berger

Ciesek

et al. 2020

Eur J Clin Microbiol Infect Dis

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“…Voigt et al determined that the seroprevalence of CMV was 27.4% in population of children and adolescents in Germany. They also reported that CMV seropositivity was significantly associated with low socioeconomic status and migration background (such as country of origin and place of birth) [13]. The rate of CMV seroprevalence among pregnant woman in Turkey was reported in the range of 92.6%-98.7% [14].…”

Section: Resultsmentioning

confidence: 99%

Seroprevalence of Cytomegaloviruses in Afghanistan

Husseini¹,

Fidan²,

Saeed³

et al. 2019

Journal of Microbiology and Infectious Diseases

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Objective: Human Cytomegalovirus (CMV) is a member of the Herpesviridae family, with the ability to establish a long-lived latent infection. CMV infection causes problems in immunocompromised hosts undergoing organ and stem cell transplantation. The prevalence of CMV in adults varies in different geographic regions. The purpose of this study was to assess the prevalence of CMV in the adult population of Afghanistan, which did not have epidemiologic information for CMV infection. Methods: A total of 500 adults residing in main regional provinces of Afghanistan including Nangarhar, Herat, Mazari Sharif, Kandahar and Kabul in the age range of 25-70 years old were randomly selected to include in the study. Among the participants, 263 (52.6%) were female and 237 (47.4%) were male. The samples were tested for the presence of CMV IgM and IgG antibodies using chemiluminescence immunoassay on the Abbott Architect automated platform. Results: The seropositivity of CMV was found 99.79 % in Afghanistan. There were no significant differences in the prevalence CMV infection among the five regions. The seropositivity anti-CMV IgG positive rate in Kandahar, Kabul, Nangarhar and, Herat was determined as 100%. The CMV IgG prevalence was 98.99% in Mazar-i Sharif. Anti CMV IgM was found 1.24% in Afghanistan. Conclusions: Our study shown that the seroprevalence is high in Afghanistan. Because of the high frequency of seropositivity in general population in Afghanistan, the approaches for preventing CMV reactivation need to be developed.

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“…Incidence and prevalence of CMV infection are associated with poor socio-economic status (SES), between countries as well as within countries and communities 49, 64, 65, 100, 114– 116 . This includes association with crowding, in particular the number of young children in household 117– 119 .…”

Section: Epidemiological Convergencementioning

confidence: 99%

The convergent epidemiology of tuberculosis and human cytomegalovirus infection

Cobelens¹,

Nagelkerke

Fletcher

2018

F1000Res

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Although several factors are known to increase the risk of tuberculosis, the occurrence of tuberculosis disease in an infected individual is difficult to predict. We hypothesize that active human cytomegalovirus infection due to recent infection, reinfection or reactivation plays an epidemiologically relevant role in the aetiology of tuberculosis by precipitating the progression from latent tuberculosis infection to disease. The most compelling support for this hypothesis comes from the striking similarity in age-sex distribution between the two infections, important because the age-sex pattern of tuberculosis disease progression has not been convincingly explained. Cytomegalovirus infection and tuberculosis have other overlapping risk factors, including poor socio-economic status, sexual contact, whole blood transfusion and solid organ transplantation. Although each of these overlaps could be explained by shared underlying risk factors, none of the epidemiological observations refute the hypothesis. If this interaction would play an epidemiologically important role, important opportunities would arise for novel approaches to controlling tuberculosis.

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Cytomegalovirus Seroprevalence Among Children and Adolescents in Germany: Data From the German Health Interview and Examination Survey for Children and Adolescents (KiGGS), 2003–2006

Abstract: CMV seroprevalence increases with age and is significantly associated with migration background, country of origin, and place of birth. We identified the birth order of siblings, breastfeeding, early day care attendance and living in East Germany as further risk factors.

Cited by 46 publications

References 37 publications

Thirty years of CMV seroprevalence—a longitudinal analysis in a German university hospital

Thirty years of CMV seroprevalence—a longitudinal analysis in a German university hospital

Seroprevalence of Cytomegaloviruses in Afghanistan

The convergent epidemiology of tuberculosis and human cytomegalovirus infection

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