Cytomegalovirus reinfection in young children

Bale, James F.; Petheram, Susan J.; Souza, Inara E.; Murph, Jody R.

doi:10.1016/s0022-3476(96)70279-2

Cited by 86 publications

(66 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In an earlier report, we documented the occurrence of CMV reinfection between pregnancies in seropositive women, and such reinfection could lead to intrauterine transmission and symptomatic congenital CMV infection (5). Several other studies have also documented CMV infection with multiple virus strains in a variety of population groups, including children attending day care centers, human immunodeficiency virusinfected individuals, allograft recipients, and infants with congenital CMV infection (1,2,10,14). Together, the findings of these studies of different population groups suggest that infections with multiple CMV strains occur frequently.…”

Section: Discussionmentioning

confidence: 76%

“…Infection with multiple strains of CMV has been shown to occur frequently in immunocompromised individuals and sexually transmitted disease (STD) clinic attendees (8,10). In addition, reinfection with different CMV strains was documented to occur in children attending day care centers (2). More recently, CMV reinfections were demonstrated in seropositive women, and such reinfections can result in intrauterine transmission and damaging fetal infection (5).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Cytomegalovirus Strain Diversity in Seropositive Women

et al. 2008

View full text Add to dashboard Cite

Infection and reinfection with multiple cytomegalovirus (CMV) strains have been shown to occur in immunocompromised individuals, sexually transmitted disease clinic attendees, and children attending day care centers. To characterize the CMV diversity in healthy seropositive individuals, 16 CMV PCR-positive specimens from 113 seropositive women were analyzed for glycoprotein gN and gB genotypes by cloning, followed by nucleotide sequencing of the plasmid DNA and/or restriction fragment length polymorphism (RFLP). The results showed that most (93.7%) of the PCR-positive specimens contained multiple gN and/or gB genomic variants, suggesting that the majority of women were infected with more than one virus strain. The results also showed that the RFLP technique might not be sufficiently sensitive to detect all of the genomic variants present in a sample.Cytomegalovirus (CMV) species are important opportunistic agents in infection of immunocompromised individuals and a frequent cause of congenital infection. Infection with multiple strains of CMV has been shown to occur frequently in immunocompromised individuals and sexually transmitted disease (STD) clinic attendees (8, 10). In addition, reinfection with different CMV strains was documented to occur in children attending day care centers (2). More recently, CMV reinfections were demonstrated in seropositive women, and such reinfections can result in intrauterine transmission and damaging fetal infection (5).Extensive genetic polymorphisms in envelope glycoproteins of CMV, including glycoprotein B (gpUL55), glycoprotein O (gpUL74), and glycoprotein N (gpUL73), have been demonstrated among clinical CMV isolates. Major envelope glycoprotein B (gB) of CMV has been demonstrated to elicit a strong neutralizing antibody response (6), and on the basis of restriction fragment length polymorphism (RFLP) analysis of clinical samples, four unique genomic variants, gB types 1 to 4, have been identified (9). Glycoprotein N has been shown to be highly polymorphic at the amino-terminal region, and most clinical CMV isolates have been shown to cluster into four distinct genomic variants, gN-1, gN-2, gN-3a, gN-3b, gN-4a, gN-4b, and gN-4c (11). Recent studies have shown that a significant proportion of the virus-neutralizing response was also directed against the gM/gN complex (17). No linkage between gN genotypes and gB genotypes has been observed (11).Published studies using RFLP analyses to determine the gN genotypes have identified only a single gN type in a given sample (11, 13). Studies of glycoprotein B based on RFLP analyses showed the presence of a single genotype or a limited number of samples containing mixtures of two gB genotypes (3, 7). However, a recent study using hybridization with typespecific probes (10) showed mixtures of all genotypes. To determine the CMV strain diversity in healthy seropositive women, the presence of multiple gN and gB genomic variants in urine or peripheral blood was examined by two different methods, RFLP and cloning followed by nucleotide se...

show abstract

Section: Discussionmentioning

confidence: 76%

mentioning

confidence: 99%

Cytomegalovirus Strain Diversity in Seropositive Women

et al. 2008

View full text Add to dashboard Cite

show abstract

“…La infección durante los primeros años de la vida guarda relación con contactos familiares, o con infecciones adquiridas en guarderías 6 . Sin embargo en nuestro estudio no se pudo confirmar en niños de 2 a 5 años una relación entre la mayor tasa de seroprevalencia y la asistencia a guardería.…”

Section: Discussionunclassified

“…En el presente trabajo no se incluyeron niños menores de 2 años, aunque previamente se ha confirmado que el 40% de los niños españoles entre 15 y 24 meses ya han sufrido infección por el virus 7 . Se ha documentado la reinfección y la coinfección por cepas distintas durante la infancia 6 . La seroprevalencia en menores de 6 meses puede elevarse al 70% 8 , como consecuencia de la adquisición pasiva de IgG materna.…”

Section: Discussionunclassified

Seroepidemiology of cytomegalovirus in the autonomous Region of Madrid

Manchón¹,

Moreno²,

López³

et al. 2001

Rev. Esp. Salud Publica

View full text Add to dashboard Cite

RESUMENFundamento: La infección por citomegalovirus (CMV) es frecuentemente asintomática. Sin embargo, constituye una importante causa de infección congénita y de patología severa en sujetos inmunodeprimidos, por lo que representa un problema en Salud Pública. El objeto de este trabajo fue conocer la prevalencia de IgG frente a CMV (IgG-CMV) en la población general madrileña.Métodos: Estudio transversal en el que se detectó IgG-CMV en una muestra representativa de la población general de la Comunidad de Madrid entre 2 y 60 años (n=2030). Se realizó un muestro bietápico estratificado por conglomerados (octubre de 1993 y febrero de 1994). Para el análisis estadístico se emplearon los test de c 2 y c 2 de tendencia lineal y se calcularon los porcentajes de seroprevalencia y los odds ratios con intervalos de confianza del 95%.Resultados: La seroprevalencia global fue del 62,8% (IC95%: 60,6-64,9); 66,7% (IC95%: 63,7-69,5) en mujeres y del 58,4% (IC95%: 55,2-61,5) en hombres. Se observó una asociación significativa entre el aumento de la edad y el incremento de la seroprevalencia. Fueron factores significativos de riesgo la consulta al dentista, antecedentes de cirugía, acupuntura y tatuajes. Los estudios superiores constituyeron un factor protector.Conclusión: Aunque los factores de riesgo detectados indican una posible transmisión vía sanguínea, la elevada prevalencia apunta a la existencia de otras vías mas comunes. El aumento de la seroprevalencia dependiente de la edad sugiere que se produce un número importante de infecciones en la edad adulta. No se puede excluir, sin embargo, que este aumento responda a un efecto cohorte debido a mejoras socioeconómicas similar al detectado para otros virus.

show abstract

“…Indeed, a onetime exposure to various viruses besides HIV-1 seem to confer no or only partial protection, allowing a secondary infection to occur in the presence of another viral strain against which an adaptive immune response has been mounted. Members of the herpes virus family, such as herpes simplex virus 1 [78] or 2 [79], Epstein-Barr virus [80], varicella zoster virus (reviewed in [81]), human herpes virus 8 [82], and notably cytomegalovirus (CMV) [83][84][85][86][87][88], provide remarkable examples of secondary infections in previously chronically infected hosts. For the scope of this review, we will limit the discussion to a few viruses that have a major impact on global health.…”

Section: Implications For Hiv-1 Vaccine Design: Lessons From Other VImentioning

confidence: 99%

Socioeconomic Impact of HIV/AIDS on Households under Free Antiretroviral Therapy in Preah Sihanouk Province, Cambodia

Nomoto¹

2012

J Antivir Antiretrovir

View full text Add to dashboard Cite

Cytomegalovirus reinfection in young children

Cited by 86 publications

References 18 publications

Cytomegalovirus Strain Diversity in Seropositive Women

Cytomegalovirus Strain Diversity in Seropositive Women

Seroepidemiology of cytomegalovirus in the autonomous Region of Madrid

Socioeconomic Impact of HIV/AIDS on Households under Free Antiretroviral Therapy in Preah Sihanouk Province, Cambodia

Contact Info

Product

Resources

About