Cytomegalovirus Isolations from Cell Cultures of Human Adenocarcmomas of the Colon

Hashiro, Glenn M; Horikami, Sandra M.; Loh, Philip C.

doi:10.1159/000149072

Cited by 35 publications

(15 citation statements)

References 8 publications

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“…[14][15][16][17][24][25][26][27] CMV has been associated with several specific human malignancies including carcinomas of the cervix, [28][29][30][31][32] prostate, [33][34][35][36] and colon. [37][38][39] However, a number of conflicting reports have either failed to show evidence of an association with CMV or have questioned the significance of the presence of CMV in these particular tumors. [40][41][42][43][44][45] There is relatively little information in the literature pertaining to CMV and brain neoplasms.…”

Section: Discussionmentioning

confidence: 99%

Lack of association of cytomegalovirus with human brain tumors

et al. 2005

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Cytomegalovirus (CMV) is thought to possess oncogenic properties and has been linked with a number of human malignancies. CMV infection was recently described in association with malignant gliomas. The intent of the present study was to further investigate the reported association between CMV and malignant gliomas. Tissue from 22 brain tumors of various histologic types and grades, four normal brains, six breast carcinomas, six colon carcinomas, six lung carcinomas, and six sarcomas were evaluated for the presence of CMV by polymerase chain reaction (PCR), in situ hybridization, and immunohistochemical methods. None of the brain tumors or normal brain tissue tested demonstrated evidence of CMV pp65 or early nuclear proteins by immunohistochemistry. In addition, no CMV RNA or DNA was detected in these cases by in situ hybridization and PCR. None of the carcinomas or sarcomas evaluated were positive for CMV by immunohistochemistry, in situ hybridization, or PCR. The findings of the present study suggest that CMV is not significantly associated with brain tumors in humans.

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Section: Discussionmentioning

confidence: 99%

Lack of association of cytomegalovirus with human brain tumors

et al. 2005

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“…Cytomegalovirus has been isolated from surgical specimens of colonic adenocarcinomas (Hashiro, Horikami & Loh, 1979) and CMV DNA has been reported to be detectable using whole virus genomic material (Huang & Roche, 1978). In contrast, Hart, Neill & Norval (1982) could find no association between CMV and carcinoma of the colon using in situ hybridization and explant techniques.…”

Section: Colonic Carcinomamentioning

confidence: 99%

The status of CMV as a human pathogen

Griffiths

Grundy

1988

Epidemiol. Infect.

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Cytomegalovirus (CMV) is a common infectious agent which is well adapted to its host. Following primary infection, which is almost always asymptomatic in people with normal immunity, the virus establishes latency at sites which are unknown. The virus is probably maintained in this latent state by immune surveillance mechanisms since immunosuppression frequently leads to reactivation of virus.Cytomegalovirus has been identified in most anatomical areas of the human body. The aim of this article is to define criteria for pathogenicity so that clinical and experimental data can be reviewed to determine if CMV is likely to cause disease at these various clinical sites. Thus, patients have been shown to die frequentlywithCMV but do they diefromit?

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“…The presence of HCMV antigens and genome in colorectal cancers has been obtained by means of molecular studies and a direct relationship between the virus and cancer was suggested [8][9][10][11][12]. The possible association of CMV with human colorectal adenocarcinomas was reported first by Huang and Roche [8] who detected CMV DNA in 4 of 7 colonic adenocarcinomas by membrane complementary RNA-DNA hybridization.…”

Section: Discussionmentioning

confidence: 99%

“…So far, studies have provided contradictory results. Some authors were able to detect CMV DNA in colorectal adenocarcinomas by different laboratorial techniques, such as in situ hybridization and PCR [8][9][10][11][12]. In contrast, others failed to demonstrate the presence of CMV in tissue samples of colorectal cancer, even using the same methods of detection [7,[13][14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Cytomegalovirus Infection in Patients With Colorectal Cancer by Using PCR Technique

Mehrabani-Khasraghi

Ghane

Ameli

2016

Zahedan J Res Med Sci

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Background: Colorectal cancer is the most common gastrointestinal cancer and the second leading cause of cancer deaths worldwide. Objectives: The purpose of this study is to investigate the prevalence of cytomegalovirus in patients with colorectal carcinomas and polyps in comparison with healthy people. Patients and Methods:In this analytical case-control study, 15 patients with colorectal cancer, 20 patients with colorectal polyps and also 35 patients without malignancy as controls were studied. Biopsy specimens were frozen under sterile conditions at -20ºC. After DNA extraction, analysis of polymerase chain reaction (PCR) to detect CMV DNA in tissue samples was performed. Statistical

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Cytomegalovirus Isolations from Cell Cultures of Human Adenocarcmomas of the Colon

Abstract: Cytomegalovirus was isolated from cell cultures derived from 3 of 16 surgical specimens of adenocarcinomas of the colon. Virus identification was accomplished through electron microscopical, cytochemical, and immunofluorescent procedures.

Cited by 35 publications

References 8 publications

Lack of association of cytomegalovirus with human brain tumors

Lack of association of cytomegalovirus with human brain tumors

The status of CMV as a human pathogen

Prevalence of Cytomegalovirus Infection in Patients With Colorectal Cancer by Using PCR Technique

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