Cytomegalovirus Infection in Ulcerative Colitis is Related to Severe Inflammation and a High Count of Cytomegalovirus-positive Cells in Biopsy Is a Risk Factor for Colectomy

Zagórowicz, Edyta; Bugajski, Marek; Wieszczy, Paulina; Pietrzak, Anna; Magdziak, Agnieszka; Mróz, Andrzej

doi:10.1093/ecco-jcc/jjw071

Cited by 50 publications

(36 citation statements)

References 29 publications

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“…Another 22 articles were further excluded by reading the full text. Ultimately, 20 [9,[15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] articles were eligible for data extraction and meta-analysis. The searching process is shown in Fig.…”

Section: Search Resultsmentioning

confidence: 99%

Risk factors of cytomegalovirus infection or reactivation in ulcerative colitis patients

Qin¹,

Dejun²,

Wang³

et al. 2020

Preprint

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Background To identify the risk factors for cytomegalovirus (CMV)infection or reactivation in ulcerative colitis (UC) patients. Method PubMed, Cochrane Library, EMBASE, Web of Science and CNKI were retrieved from the inception of electronic databases to February 2020. All analyses were performed using Stata/SE 15.1 version (StataCorp). Result 22 papers were included. There was significant difference in severe UC (OR = 1.465, 95% CI: 1.107 to 1.939, P = 0.008), pancolitis (OR = 2.108, 95% CI: 1.586 to 2.800, P = 0.0001), age of onset (MD = 6.212, 95% CI: 2.552 to 9.971, P = 0.001), glucocorticoid (OR = 4.175, 95% CI: 3.076 to 5.666, P = 0.001), immunosuppressant (OR = 2.038, 95% CI: 1.259 to 3.301, P = 0.004), 5-ASA (OR = 0.674, 95% CI: 0.492 to 0.924, P = 0.014). However, no significant difference was detected in disease duration, infliximab. Conclusion Severe UC, pancolitis, glucocorticoid, immunosuppressive therapy and age of onset are the risk factors of CMV infection or reactivation in UC patients, we should closely monitor if UC patients with the above indicators and give timely symptomatic treatment to prevent the disease from worsening.

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Section: Search Resultsmentioning

confidence: 99%

Risk factors of cytomegalovirus infection or reactivation in ulcerative colitis patients

Qin¹,

Dejun²,

Wang³

et al. 2020

Preprint

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“…Chen HP detected CMV by PCR in CRC tissues (42.3%) higher than in normal colorectal specimen (5.6%) [30]. Among 95 ulcerative colitis samples which were analyzed, 33 tissues were indicated the presence of CMV and 62 specimen were CMV negative [31]. Varicella-zoster virus is classified as one of the members of herps viridea that able to hide in nerve cells and resume activity in times of stress [32].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of herpes simplex, varicella zoster and Cytomegalovirus in tumorous and adjacent tissues of patients, suffering from colorectal cancer in Iran

et al. 2019

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Background: Colorectal cancer (CRC) can be considered as a result of multiple risks factors, and the significant role of infectious ones, especially viral diseases could not be underestimated. Despite endorsed attempts to identify the accelerating effects of different herpes viridea, such as HSV-1, HSV2, VZV and CMV on the deterioration of different kinds of malignancy, the relationship between these viruses and CRC have not successfully been understood. Taking advantages of these facts, we assessed the role of these viruses on CRC progression. Methods: In this case-control study, 88 cancerous specimens and 70 their adjacent paraffin-embedded tissues from Modares Hospital between 2011 and 2019 were collected. We extracted the DNA of each tissue and investigated the presence of HSV-1, HSV2, VZV and CMV. Results: Our data indicated the presence of HSV-1 DNA in the three control samples; however, we could not find an obvious relationship between HSV2, VZV, CMV infection and this type of cancer. The presence of HSV-1 DNA in control tissues introduced HSV-1 as a probable factor for the killing of colorectal cancer cells. Conclusions: we supposed that HSV-1 can function as an inhibitor of colon cancer progresion, but it is required to studied more in order to find the role of this virus on CRC.

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“…In the high-density group, antiviral treatment significantly reduced the surgical rate. Regarding colectomy, Zagórowicz et al [37] reported that the group with numerous HCMV-infected cells in their intestinal tissue showed a significant decrease in colectomy rate with antiviral treatment. Kim et al [38] conducted a prospective study of 72 UC patients who were moderately or severely treated with steroids.…”

Section: Efficacy Of the Antiviral Treatmentmentioning

confidence: 99%

Current Diagnostic and Therapeutic Approaches to Cytomegalovirus Infections in Ulcerative Colitis Patients Based on Clinical and Basic Research Data

Yokoyama

Yamakawa

Hirano

et al. 2020

IJMS

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Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus (the human herpesvirus 5) and an opportunistic pathogen that primarily infects HIV-positive and other immuno-compromised patients. Retrospective studies in the field of inflammatory bowel disease (IBD) have suggested a relationship between a concomitant colonic HCMV infection and poor outcomes in patients with an ulcerative colitis (UC) due to the presence of HCMV in surgical specimens of patients with a toxic megacolon or a steroid-resistant UC. Therefore, gastroenterologists have focused on the contribution of HCMV infections in the exacerbation of UC. Numerous studies have addressed the benefits of treating colonic HCMV reactivation in UC using an antiviral treatment. However, its clinical relevance remains uncertain as only a few prospective studies have assessed the direct relationship between clinical outcomes and the viral load of HCMV in colonic tissues. HCMV reactivation can be triggered by inflammation according to fundamental research studies. Thus, optimal control of intestinal inflammation is essential for preventing an HCMV reactivation in the intestinal mucosa. Indeed, several reports have indicated the effectiveness of an anti-tumor necrosis factor-alpha (TNFα) treatment in patients with an active UC and concomitant HCMV infections. In this review, we describe the mechanism of HCMV reactivation in UC cases and discuss the current issues regarding diagnosis and treatment of HCMV infections in UC patients.

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Cytomegalovirus Infection in Ulcerative Colitis is Related to Severe Inflammation and a High Count of Cytomegalovirus-positive Cells in Biopsy Is a Risk Factor for Colectomy

Abstract: Five or more CMV IHC-positive cells per biopsy section were indicative of a greater colectomy risk. CMV infection was related to more severe inflammation. Blood CMV PCR is a useful tool in UC.

Cited by 50 publications

References 29 publications

Risk factors of cytomegalovirus infection or reactivation in ulcerative colitis patients

Risk factors of cytomegalovirus infection or reactivation in ulcerative colitis patients

Prevalence of herpes simplex, varicella zoster and Cytomegalovirus in tumorous and adjacent tissues of patients, suffering from colorectal cancer in Iran

Current Diagnostic and Therapeutic Approaches to Cytomegalovirus Infections in Ulcerative Colitis Patients Based on Clinical and Basic Research Data

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