Cytomegalovirus infection in the genital tract of HIV-seropositive women

Wales, N.; Nordin, Andy; Newell, A; Smith, J. R.; Barton, Staci C.; Nelson, Mark

doi:10.1097/00002030-199606001-00023

Cited by 6 publications

(12 citation statements)

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“…À high-risk' behaviour and concurrent local infections may act as co-factors promoting increased transmission and/or re-activation of CMV infection 6,14± 19 . As sexual transmission of CMV is well known, recent studies stressed the elevated frequency of CMV cervical shedding in both non-HIV-infected and HIV-infected female patients (with higher prevalence among the last ones) 18 , and postulated a possible role of CMV in the pathogenesis of pelvic in¯ammatory disease 16,19 .…”

Section: Discussionmentioning

confidence: 99%

“…To our best knowledge, only 3 cases of CMV oophoritis have been reported to date in immunocompromised pre-menopausal adult females with HIV disease 11,13,16 . The ® rst 2 cases were not accompanied by suggestive clinical manifestations and were disclosed only by postmortem histopathological studies 11,13 , while the third described patient has signs and symptoms suggesting a pelvic in¯ammatory disease 16 .…”

Section: Discussionmentioning

confidence: 99%

“…The ® rst 2 cases were not accompanied by suggestive clinical manifestations and were disclosed only by postmortem histopathological studies 11,13 , while the third described patient has signs and symptoms suggesting a pelvic in¯ammatory disease 16 .…”

Section: Discussionmentioning

confidence: 99%

“…In 1996, Wales and collaborators reported a severely immunocompromised woman who developed lower abdominal pain and dyspareunia, and ® nally underwent a diagnostic laparoscopy with multiple biopsies, which revealed an extensive involvement of salpinges, myometrium, endometrium, and cervix, together with the ovaritis 16 .…”

Section: Discussionmentioning

confidence: 99%

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Silent oophoritis due to cytomegalovirus in a patient with advanced HIV disease

Manfredi¹,

Alampi

Talò³

et al. 2000

Int J STD AIDS

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Silent oophoritis due to cytomegalovirus in a patient with advanced HIV disease

Manfredi¹,

Alampi

Talò³

et al. 2000

Int J STD AIDS

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“…CMV is an opportunistic infection in immunocompromised patients and has been reported in the lungs, brain, gastrointestinal tract, liver, heart and retina. It has also been reported as occurring in the genital tract of patients with HIV undergoing colposcopy ( 67 ) in whom its occurrence was believed to be incidental, as the patients were asymptomatic at the time. Subsequently, both patients in this report developed symptomatic infection in the form of CMV pelvic inflammatory disease in one case and disseminated infection in the other.…”

Section: Viral Infectionsmentioning

confidence: 99%

Infection and cervical intraepithelial neoplasia

Boyle

Smith

1999

Int J Gynecol Cancer

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The impact of sexually transmitted diseases (STDs) on the development of cervical intraepithelial neoplasia (CIN) has been increasingly recognized over the last 20 years. Much attention has been focused on human papillomavirus (HPV) and the potential for screening for certain HPV types alongside standard cervical cytology in the hope of identifying those females at particular risk of developing high grade CIN or invasive carcinoma. Some infections, for example herpes simplex virus (HSV), have been heavily investigated in the past as they were thought to be involved in the development of CIN but were subsequently discounted. Also discounted as causes of CIN are Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT). These infections were found to be associated with higher rates of CIN in early studies but transpired to be markers for the presence of other infections and pathology and therefore not themselves directly responsible for cytological changes. The role of bacterial vaginosis (BV) is the focus of several current investigations, not only in the genesis of CIN but also in the development of other gynecological and obstetric conditions and complications. Evidence to implicate Trichomonas vaginalis (TV) in the genesis of CIN is conflicting, but there is some evidence that it may exert its influence in a similar way to that hypothesized for BV, ie via abnormal amines. It is well known that there is a high level of concordance of STDs whereby the presence of one infection greatly increases the likelihood of there being one or more others present. There may be a synergism between some infections with regard to the causation of CIN, although the evidence for this is putative. Presented here is an overview of current and previous research in the field of lower genital tract infection as it relates to the development of CIN.

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