Cytomegalovirus infection in severe burn patients monitoring by real-time polymerase chain reaction: A prospective study

Bordes, Julien; Maslin, J.; Prunet, Bertrand; D’Aranda, Erwan; Lacroix, Guillaume; Goutorbe, Philippe; Dantzer, E.; Meaudre, Éric

doi:10.1016/j.burns.2010.11.006

Cited by 33 publications

(30 citation statements)

References 18 publications

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“…Recently, increasing evidence has suggested that HCMV reactivation might have been considerably underestimated in burn patients [5,6]. Review of the available literature identifies .50% of HCMV antibody-positive burn patients may reactivate this virus [5,6]. Although the exact mechanisms of HCMV reactivation are still not clearly understood, the immune system and host genetics are thought to be the non-behavioral factors determining the acquisition of a reactivation.…”

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confidence: 99%

“…However, in immunocompromised people who suffer from burn injuries, HCMV reactivation has been shown to lead to significant diseases with considerable morbidity and mortality [2][3][4]. Recently, increasing evidence has suggested that HCMV reactivation might have been considerably underestimated in burn patients [5,6]. Review of the available literature identifies .50% of HCMV antibody-positive burn patients may reactivate this virus [5,6].…”

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confidence: 99%

“…A total of 160 burn patients, who met the following inclusion criteria, were included: (i) be able to give informed consent (either from patient or relatives); (ii) total burn surface area (TBSA) .15% [5]; (iii) expected survival .72 h; (iv) HCMV-IgG seropositive within 24 h from admission; (v) no known or suspected underlying immunodeficiency (solid organ or hematopoietic stem cell transplant, human immunodeficiency virus infection, congenital immunodeficiency, and receipt of immunosuppressive agents). Characteristics of these patients such as age, gender, %TBSA, and inhalation injury are listed in Table 1.…”

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confidence: 99%

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Association of human leukocyte antigen E polymorphism with human cytomegalovirus reactivation in Chinese burn patients

Gong¹,

Ding²,

Jiang³

et al. 2013

ABBS

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confidence: 99%

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Association of human leukocyte antigen E polymorphism with human cytomegalovirus reactivation in Chinese burn patients

Gong¹,

Ding²,

Jiang³

et al. 2013

ABBS

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“…So konnte bei 29 Patienten mit Verbrennungen von >15% KOF mithilfe der Polymerase-Kettenreaktion eine CMV-Infektion bei 12,5% der seronegativen (Neuinfektion) und 71% der seropositiven Patienten (Reaktivierung) nachgewiesen werden [4]. Eine weitere Studie untersuchte 308 Patienten, bei denen aufgrund einer respiratorischen Insuffizienz eine Bronchoskopie mit mikrobiologischer Materialgewinnung erfolgte [36].…”

Section: Virale Infektionenunclassified

Antimikrobielle Therapie bei Patienten nach Verbrennungstrauma

et al. 2012

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Infections are a great diagnostic and therapeutic challenge in intensive care patients with burn injuries. The major problems are due to bacteria with hospital-acquired multiresistance to antibiotics but fungal and viral infections may also be life-threatening. The main key points addressing pharmacotherapy with antibiotic, antifungal and antiviral agents in this special setting are exact diagnosis, early therapy with suitable drugs, adequate duration of treatment and adequate doses based on pharmacokinetic and pharmacodynamic characteristics of these compounds. The latter parameters are significantly altered in burn patients and show a wide interindividual and intraindividual variation in drug response as a result of the characteristic phases of burn injury. Drug concentration analysis may help to avoid inadequate dosing. In this review the main characteristics of burn injuries and the pharmacology of antibiotics, antifungal and antiviral agents in these patients are presented.

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“…In the last decade the role of serious infections in activation of latent HCMV infection in immunocompetent patients also is being scrutinised. The studies comprised critically ill patients treated at intensive care units (ICU) [4][5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Presence of human cytomegalovirus DNA in blood of patients with community-acquired pneumonia

Saletinger

Poljak

Strle

2015

Clinical Microbiology and Infection

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After a primary infection, human cytomegalovirus (HCMV) remains latent in certain human cells. Different stimuli, including immune deficiency and severe infection, can trigger the reactivation of latent HCMV infection. In the last decade, the role of the reactivation in immunocompetent patients with serious illness has been intensely studied; however, the knowledge of the potential role of moderately severe infections on HCMV dynamics is limited. In the prospective study, 80 HCMV-seropositive, immunocompetent adult patients with community-acquired pneumonia (CAP), treated outside the intensive care unit (ICU), were monitored with real-time polymerase chain reaction (PCR) for the presence of HCMV DNA. Detection of HCMV DNA in whole blood and/or plasma was interpreted as reactivation of latent HCMV infection. HCMV DNA was detected in 6 of 80 (7.5%) patients. All HCMV DNA-positive patients were classified according to the pneumonia severity index (PSI) as high-risk classes IV or V; thus, HCMV DNAaemia rate within these two PSI classes was 16.7%. All of the patients had positive whole blood samples, whereas plasma samples were positive in a single patient. We did not detect any significant differences comparing six patients with proven HCMV DNAaemia and 74 patients in whom HCMV DNAaemia was not demonstrated regarding the levels of inflammatory parameters on admission, length of treatment with supplemental oxygen, and length of hospital stay. In conclusion, the finding of HCMV DNAaemia in patients with CAP treated outside the ICU is a rare event and occurs only in patients with PSI classes designating more severe pneumonia.

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Cytomegalovirus infection in severe burn patients monitoring by real-time polymerase chain reaction: A prospective study

Cited by 33 publications

References 18 publications

Association of human leukocyte antigen E polymorphism with human cytomegalovirus reactivation in Chinese burn patients

Association of human leukocyte antigen E polymorphism with human cytomegalovirus reactivation in Chinese burn patients

Antimikrobielle Therapie bei Patienten nach Verbrennungstrauma

Presence of human cytomegalovirus DNA in blood of patients with community-acquired pneumonia

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