Cytomegalovirus Infectıon in Renal Transplant Recipients: One Center's Experience

Bal, Zeynep; Uyar, Murathan; Tutal, Emre; Erdoğan, Elçin; Çolak, Turan; Sezer, Sıren; Haberal, Mehmet

doi:10.1016/j.transproceed.2013.08.098

Cited by 14 publications

(16 citation statements)

References 17 publications

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“…A longer duration of GCV treatment in patients receiving Tac may indicate its greater immunosuppressive potential. Our observation is confirmed by the results obtained by other authors [4].…”

Section: Discussionsupporting

confidence: 93%

Cytomegaloviral Infection in Solid Organ Transplant Recipients: Preliminary Report of One Transplant Center Experience

Hryniewiecka

Sołdacki

Pączek

2014

Transplantation Proceedings

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Section: Discussionsupporting

confidence: 93%

Cytomegaloviral Infection in Solid Organ Transplant Recipients: Preliminary Report of One Transplant Center Experience

Hryniewiecka

Sołdacki

Pączek

2014

Transplantation Proceedings

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“…Hepatitis B virus and hepatitis C virus positivity was seen in one patient each (2/7 cases, 28.6%). A recent study from Turkey revealed positive hepatitis B and C serology in 17.6% of CMV positive cases (14). Another study found HCV positivity in 28.6% of CMV positive recipients (15).…”

Section: Cytomegalovirusmentioning

confidence: 96%

“…Alternatively UTI can reactivate latent CMV virus by releasing pro-inflammatory cytokines which trigger CMV replication (16). Urine leucocyte counts were also found to be higher in CMV positive recipients (14). Further research is essential to understand the link between UTIs and CMV infection.…”

Section: Cytomegalovirusmentioning

confidence: 99%

“…Another study from North India also did not reveal any morphological evidence of acute rejection in the immunohistochemical CMV positive cases but showed varying degrees of tubulointerstitial inflammation (12), similar to our study. In contrast the study from Turkey showed that acute rejection episodes are more frequent in the CMV-positive group (14). CMV infection is associated with chronic allograft nephropathy that causes myointimal thickening leading to graft failure (3).…”

Section: Cytomegalovirusmentioning

confidence: 99%

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Prevalence of cytomegalovirus and BK polyoma virus infection in post-renal transplant patients in a tertiary care centre in

Manuel¹,

Ambroise²,

Varghese³

et al. 2017

J Nephropathol

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Background: Viral infections are a significant cause of graft loss and dysfunction in kidney transplant recipients. Cytomegalovirus and BK polyomavirus have often been explained as the most common viral etiological agents. Objectives: The current study was undertaken to assess the prevalence of cytomegalovirus and BK polyomavirus infection in post-renal transplant individuals in a tertiary care centre in South India and also to study the histopathological changes of such infections in the kidney allograft biopsies. Patients and Methods:We conducted a retrospective investigation of 100 cases using archival renal biopsy specimens which were subjected to immunohistochemical stains to detect cytomegalovirus and BK polyoma virus. These findings were then correlated with the histopathological alterations detected in H&E sections. Results: We detected the prevalence of cytomegalovirus in 7% and BK polyoma virus in 3%. Cytomegalovirus was statistically associated with pre-and post-transplant infections along with diabetic status. We noted that, out of the seven patients who were immunohistochemically cytomegalovirus positive, only five had positive cytomegalovirus IgM status. With BK polyoma virus, we noted a statistical significance with pre-and posttransplant infections. However, we did not find evidence of cytomegalovirus and BK polyoma virus co-infection in any of the renal allograft biopsies. Conclusions: Routine immunohistochemical evaluation of cytomegalovirus and BK polyoma viral infections in kidney allograft recipients must be done, especially in those with preand post-transplant infections and diabetes.

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“…We found that HLA-B48 and HLA-B57 have a significant influence in CMV disease after transplantation and HLA-DRB1*09 indicates the opposite results. In the literature, HLA alleles are recognized as risk factors for CMV disease, but some of them can have a protective role [16][17][18][19], and this situation might be useful pretransplant in estimating the risk of CMV disease after transplantation and designing individualized therapy. A better understanding of the different HLA associated immune mechanism within CMV disease may lead to improved management strategies in kidney transplantation.…”

Section: Letter To the Editormentioning

confidence: 99%

Association of Human Leukocyte Antigen and Cytomegalovirus disease after Kidney Transplantation

Luscalov

Loga

et al. 2017

Revista Romana De Medicina De Laborator

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Cytomegalovirus Infectıon in Renal Transplant Recipients: One Center's Experience

Cited by 14 publications

References 17 publications

Cytomegaloviral Infection in Solid Organ Transplant Recipients: Preliminary Report of One Transplant Center Experience

Cytomegaloviral Infection in Solid Organ Transplant Recipients: Preliminary Report of One Transplant Center Experience

Prevalence of cytomegalovirus and BK polyoma virus infection in post-renal transplant patients in a tertiary care centre in

Association of Human Leukocyte Antigen and Cytomegalovirus disease after Kidney Transplantation

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