Cytomegalovirus infection in patients with glomerular diseases treated with cyclophosphamide: a single-center prospective study

Sahin, Gizem Kumru; Eyupoglu, Sahin; Sadioğlu, Rezzan Eren; Çınar, Güle; Ateş, Kenan; Ertürk, Şehsuvar; Nergızoğlu, Gökhan; Şengül, Şule; Kutlay, Sim; Keven, Kenan

doi:10.1007/s11255-021-02973-w

Cited by 2 publications

(1 citation statement)

References 20 publications

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“…Hence, prophylactic therapy might be considered. A single-center prospective study in Turkey proposed a cut-off of 500 copies of CMV DNA per ml to treat CMV infection and improve outcomes in glomerulonephritis patients [ 101 ]. Furthermore, a risk stratification algorithm was proposed by Lim et al to decide who deserved antiviral agents among patients with GN with positive CMV [ 102 ].…”

Section: Immunosuppressive Treatment and Infectionmentioning

confidence: 99%

Autoimmunity and Infection in Glomerular Disease

Casuscelli,

Longhitano,

Maressa

et al. 2023

Microorganisms

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The ongoing glomerular damage of infections is not limited to the most widely known form of post-streptococcal glomerulonephritis, which is today less common in the Western world; other forms of glomerulonephritis are associated with several bacterial, viral and parasitic pathogens. The mechanisms responsible range from the direct damage of glomerular cells to the formation and deposition of immunocomplexes to molecular mimicry to the secretion of superantigens. Similarly, in the course of glomerular disease, infections are more frequent than in the general population due to the loss of immunoglobulins in urine and the immunosuppressive agents used to treat the autoimmune disease that decrease the activity of the immune system. Recognizing this two-way link, understanding its pathogenetic mechanism, and identifying the most appropriate therapeutic choice are essential for the personalized management of patients. In this continuously developing field, this short review summarizes the current state of the art as support for physicians, who are increasingly involved in managing patients with glomerular disease and infections.

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Section: Immunosuppressive Treatment and Infectionmentioning

confidence: 99%

Autoimmunity and Infection in Glomerular Disease

Casuscelli,

Longhitano,

Maressa

et al. 2023

Microorganisms

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Retinal ghost in a patient with Behçet's disease and positive cytomegalovirus PCR in the vitreous sample

Maleki,

Foster,

Foster

2024

European Journal of Ophthalmology

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Purpose To document a case involving a patient previously diagnosed with Behçet's disease which proved unresponsive to multiple immunomodulatory therapies, and was subsequently diagnosed with secondary cytomegalovirus retinitis and appropriately treated. Methods This is a case report focused on the images. Results A 39-year-old female, previously diagnosed with Behçet's disease unresponsive to multiple immunomodulatory therapies, sought a second opinion at our clinic due to more floaters and a scotoma in her left eye for a few months. Her right eye had become blind as a result of multiple glaucoma and vitreoretinal surgeries. Her best corrected visual acuity was 20/60 in the left eye. A Slit lam examination of the left eye showed 1+ cells and flare in the anterior chamber along with 1+ cells in the anterior vitreous with no vitreous haze. Dilated fundoscopy of the left eye reveled an atrophic lesion in the inferior macula. Fluorescein angiography demonstrated a mixed hypo- and hyperfluorescent lesion in the left eye. Optical coherence tomography macula demonstrated an atrophic lesion in the inferior macula of the left eye. All laboratory findings were predominantly negative or within the normal range, except for the presence of antibodies to VZV and CMV in the blood. Polymerase chain reaction analysis of the vitreous sample uncovered the presence of CMV, leading to appropriate curative and prophylactic treatment for the patient. Conclusions and importance In patients with resistant noninfectious uveitis, particularly those experiencing underlying disease reactivation, the possibility of infections, especially opportunistic ones, should be taken into consideration.

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Cytomegalovirus infection in patients with glomerular diseases treated with cyclophosphamide: a single-center prospective study

Cited by 2 publications

References 20 publications

Autoimmunity and Infection in Glomerular Disease

Autoimmunity and Infection in Glomerular Disease

Retinal ghost in a patient with Behçet's disease and positive cytomegalovirus PCR in the vitreous sample

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