Cytomegalovirus Infection in Immunosuppressed Patients After Kidney Transplantation

Luscalov, Simona; Loga, Luminița; Dican, Lucia; Junie, Lia Monica

doi:10.15386/cjmed-587

Cited by 14 publications

(14 citation statements)

References 27 publications

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“…CMV often has indirect effects in the kidney such as Renal artery stenosis, interstitial nephritis, thrombotic microangiopathy or allograft ureteral strictures or nephritis leading to kidney dysfunction [53].…”

Section: Clinical Manifestationsmentioning

confidence: 99%

“…Several methods exist for the detection and diagnosis of cytomegalovirus however, many have limited clinical utility. Among the less frequently used tests are latex agglutination, complement fixation, and enzyme-linked immunoassays (ELISA) [53]. However, CMV infection is primarily diagnosed by the detection of CMV replication in blood or tissues using nucleic acid testing (NAT), antigen testing, or viral culture.…”

Section: Diagnosismentioning

confidence: 99%

See 1 more Smart Citation

Cytomegalovirus and Kidney Transplantation: An Update

Senere¹,

Rogozinski²,

George³

et al. 2023

OBM Transplant

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Cytomegalovirus (CMV) infection is the most common infection affecting kidney transplant recipients [1]. CMV may be present as asymptomatic viremia or with symptoms ranging from mild to significant tissue-invasive disease [1-3]. Optimal kidney graft function and survival requires that transplant care teams carefully assess individual patient risk of CMV [2, 3]. Appropriate patient surveillance and prophylaxis are essential to ensure the best long-term kidney transplant results. Effective treatment of CMV disease requires a high degree of suspicion and appropriate diagnostic tests. The choice of antiviral medication and duration of treatment are important considerations to ensure optimal patient outcomes and kidney graft function and survival.

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Section: Clinical Manifestationsmentioning

confidence: 99%

Section: Diagnosismentioning

confidence: 99%

Cytomegalovirus and Kidney Transplantation: An Update

Senere¹,

Rogozinski²,

George³

et al. 2023

OBM Transplant

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“…Endoscopic findings may include nasal polyps, mucopurulent discharge primarily from the middle meatus, and/or edema or mucosal obstruction primarily in the middle meatus. Furthermore, CT imaging may show mucosal changes within the ostiomeatal complex and/or sinuses 103 . Viral etiology is assumed if symptoms resolve within 10 days of onset, but if symptoms persist beyond this timeframe, bacterial causation should be investigated 104 …”

Section: Headache or Facial Pain Attributed To Disorder Of The Craniumentioning

confidence: 99%

“…68 Cytomegalovirus infection in an immunocompromised host may present with flu-like symptoms such as fever, malaise, myalgia, or arthralgia, as well as GI symptoms such as nausea, vomiting, and ileus. 69 Viruses can spread to the meninges and brain parenchyma directly through the bloodstream, via retrograde transmission from nerve endings back to the CNS, or by reactivation from a dormant state within the CNS. 70 Neurotropic viruses such as mumps, can directly infect the choroid plexus epithelium.…”

Section: Headache Attributed To Viral Meningitis or Encephalitismentioning

confidence: 99%

Secondary Headache: Current Update

Born

Dilli

2020

Headache

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Purpose The purpose of this paper is to review some of the causes of secondary headache particularly focusing on the subcategories of secondary headache in the International Classification of Headache Disorders, 3rd edition, the clinical features of these headaches, and their associated features and management. Overview Headache attributed to trauma or injury to the head and/or neck, headache attributed to cranial or cervical vascular disorder, headache attributed to non‐vascular intracranial disorder, headache attributed to a substance or its withdrawal, headache attributed to infection, headache attributed to disorder of homeostasis, and headache or facial pain attributed to disorder of the cranium, neck, eye, ears, nose, sinuses, teeth, mouth, or other facial or cervical structure are discussed in this paper. Discussion Headache is a common symptom of multiple medical conditions. Although a minority of headache patients have a secondary basis for their headaches, it is important to identify clinical features of secondary headache disorders including both the headache and non‐headache features of the condition, diagnose the secondary etiology correctly, and treat them appropriately.

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“…The diagnosis of CMV depends mainly on laboratory techniques. Laboratory diagnosis can be performed by several methods either by determinations of specific antibodies either specific immunoglobulin M and.or G by enzyme linked immunosorbant assay (ELISA) , agglutination latex and complement fixation test or antigen detection of CMV pp65 protein in peripheral leucocytes by immunofluorescence technique and detection of CMV viral DNA by molecular techniques [11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Molecular Study of Cytomegalovirus Infection among Children with End Stage Renal Diseases Undergoing Dialysis, Pilot Study

2017

Medical &Amp; Clinical Research

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Cytomegalovirus is considered as an opportunistic infection affecting immunocompromized patients. Children with end stage renal diseases requiring dialysis is among affected population by this virus. The aim of the present study was to detect and compare the seroprevalence of CMV and CMV antigen pp65 with real time polymerase chain reaction (PCR) among children with end stage renal diseases undergoing dialysis. The study is a prospective case - control study. The forty one patients included in the studied are registered in the hospital for regular dialysis waiting for renal transplantation. The study included forty one healthy controls with same age and gender distribution. Blood samples were obtained from studied children and subjected for determination of specific immunoglobulin M and G for CMV (IgM-CMV, IgG-CMV) by Elecys system and CMV-DNA determination by real time polymerase chain reaction (PCR) and for PP65 antigenaemia test by light diagnostic CMVpp65. CMV-IgM was significantly detected frequently (P=0.0001) in 12.2% of the patients and in 2.4% of the control children. Moreover, IgG-CMV was significantly more frequently detected in patients (P=0.0001) than in control (90.2%&31.7% respectively). CMV-DNA was significantly (P=0.0001) detected in 12 patients (29.3%) compared to the control (2.4%), while CMVpp65 was detected among 4 children (9.8%) compared to one child in the control group. The comparison between IgM-CMV and real time PCR revealed that 30.7% of positive samples by PCR had positive IgMCMV, while IgG-CMV was associated with 84.6% of positive PCR. CMVpp65 correctly identified all negative samples compared to PCR, while the majority of negative PCR was also negative for IgM-CMV (98.6%). Moreover, all negative children for CMVpp65 was also negative by PCR (100%) For the validity of different CMV markers, IgG-CMV was the most sensitive test (84.7%), CMVpp65 was the most specific test 100%. From this study we concluded that CMV is a common viral infection among children with end stage renal diseases requiring dialysis. The diagnostic performance of real time PCR is the gold standard technique in diagnosis of this infection. CMVpp65 antigenemia is a specific accurate test for laboratory diagnosis however, it lacks sensitivity. Specific IgG for CMV is good screening diagnostic test.

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Cytomegalovirus Infection in Immunosuppressed Patients After Kidney Transplantation

Cited by 14 publications

References 27 publications

Cytomegalovirus and Kidney Transplantation: An Update

Cytomegalovirus and Kidney Transplantation: An Update

Secondary Headache: Current Update

Molecular Study of Cytomegalovirus Infection among Children with End Stage Renal Diseases Undergoing Dialysis, Pilot Study

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