Cytomegalovirus infection in immunocompetent adults: Is observation still the best strategy?

Nangle, Sarah; Mitra, S.; Roskos, Steven E.; Havlichek, Daniel H.

doi:10.1016/j.idcr.2018.e00442

Cited by 19 publications

(14 citation statements)

References 12 publications

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“…When treatment is indicated, it is usually continued for 2 to 3 weeks followed by documented clearance of virus from the blood [ 2 ]. A recent case series of CMV infection in immunocompetent patients who received anti-CMV therapy showed significant improvement in symptoms within a few days of starting therapy [ 18 ]. Our patient was treated with valganciclovir for total of 21 days.…”

Section: Discussionmentioning

confidence: 99%

Acute Cytomegalovirus (CMV) Hepatitis in an Immunocompetent Adult

et al. 2020

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Section: Discussionmentioning

confidence: 99%

Acute Cytomegalovirus (CMV) Hepatitis in an Immunocompetent Adult

et al. 2020

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“…Although clinically significant CMV infection is considered rare in immunocompetent individuals, there are multiple reports in literature highlighting that it should be considered in differential diagnoses [ [3] , [4] , [5] , [6] , [7] , [8] , [9] ]. Multiple organ systems can be affected by CMV, the most common being gastrointestinal tract with manifestations such as colitis, gastritis, gastric ulcer [ 10 , 11 ], hepatitis [ 12 ], pancreatitis [ [12] , [13] , [14] , [15] ], duodenitis, or enteritis.…”

Section: Discussionmentioning

confidence: 99%

Cytomegalovirus pancreatitis in an immunocompetent patient

Saeed

Nwogbo

Gani

et al. 2020

IDCases

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Cytomegalovirus (CMV) is a double-stranded DNA virus, which infects a large portion of the adult population. In immunocompetent patients, it typically is asymptomatic or manifests as mild and self-limiting flu-like illness symptoms, whereas in immunocompromised patients, CMV can cause significant disease. Herein we report an unusual case of CMV pancreatitis in an immunocompetent 75-year-old female. Patient developed severe significant pancreatic necrosis that failed non-operative management, and ultimately underwent pancreatic necrosectomy. Later on, she developed three spontaneous gastric perforations. The first two perforations were managed operatively, but after the third perforation family decided not to undergo another operation. The CMV pancreatitis diagnosis was based on pancreatic histopathology and confirms by a prompt response to ganciclovir. Patient was promptly started on intravenous (IV) ganciclovir which resulted in clinical recovery and she remained asymptomatic more than one-year post op. This is a rare case of CMV pancreatitis with gastric perforations in an immunocompetent patient. High degree of suspicion and appropriate treatment are important for such clinical scenarios.

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“…Infection presents with unspecific manifestations, such as fever and lymphadenopathy [75]. Skin lesion, lymphadenitis, and suppurative complications are non-typical.…”

Section: Cytomegalovirus (Cmv) Infectionmentioning

confidence: 99%

Tularaemia – a diagnostic challenge

Wawszczak¹,

Banaszczak²,

Rastawicki³

2021

Ann Agric Environ Med.

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Introduction.Tularaemia is an infrequently occurring disease in Poland. It has therefore rarely been taken into account in the differential diagnosis of skin lesions, lymphadenitis, or soft tissue abscesses. This fact, accompanied by non-specific initial presentation, may lead to a delay in diagnosis and a more severe course of the disease. Objective. The aim of the study is to present the current state of knowledge on tularaemia and convince medical professionals to take it into consideration in the diagnosis of skin lesions, lymphadenitis, and tissue abscesses. Review methods. A literature review using PubMed and other online resources, using terms including 'tularaemia', 'lymphadenitis', etc., was undertaken. Papers were reviewed for relevance and scientific merit. Abbreviated description of the state of knowledge. Tularaemia, also known as 'rabbit fever', is a zoonotic infection caused by Francisella tularensis, an aerobic, facultative intracellular, gram-negative bacteria. In Europe, it is mainly spread via tick bites and contact with wild animals such as lagomorphs and rodents. Clinical presentation may differ depending on the transmission route; the ulceroglandular and glandular forms of disease predominate. An early diagnosis and implementation of appropriate antibiotic therapy are the cornerstones of successful treatment and make it possible to avoid a surgical incision and drainage of suppurative complications. Summary. Raised awareness and knowledge on tularaemia among health care professionals are required for timely diagnosis and treatment. Arrival from endemic areas, contact with wild animals, tick bites, and exclusion of more common etiologies of presenting signs should prompt consideration of tularaemia. More research is needed for a better understanding of the burden of the disease and its impact on public health in Poland.

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Cytomegalovirus infection in immunocompetent adults: Is observation still the best strategy?

Cited by 19 publications

References 12 publications

Acute Cytomegalovirus (CMV) Hepatitis in an Immunocompetent Adult

Acute Cytomegalovirus (CMV) Hepatitis in an Immunocompetent Adult

Cytomegalovirus pancreatitis in an immunocompetent patient

Tularaemia – a diagnostic challenge

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