Cytomegalovirus infection in HIV-1-infected individuals

Süttmann, U.; Willers, H; Gerdelmann, R.; Höpken, W; Schedel, I.; Deicher, H.

doi:10.1007/bf01644316

Cited by 16 publications

(8 citation statements)

References 14 publications

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“…A much larger percentage of infections are diagnosed at autopsy. The more common clinical manifestations include retinitis, pneumonitis, hepatitis, cnteriti.s and cnccphaliti.s (14,15). CMV disease involving the gastrointestinal (GI) tract is a relatively common manifestation of infection in both AIDS and bone marrow transplant (BMT) patients.…”

mentioning

confidence: 99%

Oral infections due to Cytomegalovirus in immunocompromised patients

Schubert

Epstein

Lloid

et al. 1993

J Oral Pathology Medicine

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Herpes group virus infections in the immunocompromised host are associated with significant morbidity and mortality. Herpes simplex virus (HSV) and to a lesser extent varicella zoster virus (VZV) have long been recognized as causes of oral and peri-oral lesions in subjects undergoing bone marrow transplantation and in individuals infected with the Human Immunodeficiency Virus (HIV). A role for Cytomegalovirus (CMV) in such lesions is less clear and not well documented. This report describes two bone marrow transplant recipients and one individual infected with HIV in whom CMV was implicated as the cause of oral lesions. Diagnostic and management issues as well as clinical implications are discussed.

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mentioning

confidence: 99%

Oral infections due to Cytomegalovirus in immunocompromised patients

Schubert

Epstein

Lloid

et al. 1993

J Oral Pathology Medicine

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“…All isolation attempts (table 1) remained negative except for two CMV isolations from two duodenal biopsies of patient 806 (day 141), who suffered from abdominal pain. The patient was positive for CMV antibodies by IgG EL-ISA and CFT, but always negative for CMV IgM antibodies [25]. Patient 806 suffered from an unexpected rapid deterioration to AIDS after day 155.…”

Section: Virus Isolationmentioning

confidence: 96%

“…The patient was positive for CMV antibodies by IgG EL ISA and CFT, but always negative for CMV IgM antibodies [25]. Patient 806 suffered from an unexpected rapid dete rioration to AIDS after day 155.…”

Section: Virus Isolationmentioning

confidence: 99%

“…CMV could be isolated from the same patient on day 141 from two duodenal biopsies. One may speculate that this infection was an additional factor in the rapid deterioration 1 [25].…”

Section: Human Herpesvirusesmentioning

confidence: 99%

“…Concerning HSV and CMV, titer rises in CFT as well as demonstration of IgM antibodies can occur in some cases but are not consistently observed [11,12]. Even in the pa tient with CMV isolation, no serological indication for a CMV reactivation was seen [11,25].…”

Section: Human Herpesvirusesmentioning

confidence: 99%

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Virological Examinations of Patients with AIDS-Related Complex/Walter-Reed 5 Enrolled in a Double-Blind Placebo-Controlled Study with Intravenous Gammaglobulin Administration

Mertens¹,

Ramon²,

Kruppenbacher³

et al. 1990

Vox Sanguinis

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Thirty patients with AIDS-related complex/Walter-Reed 5 enrolled in a placebo-controlled double-blind study with high-dose intravenous gammaglobulin administration were tested by quantitating HIV Western blot and other serological tests for viral antibodies. Furthermore, conventional virus isolation attempts were performed. Absence or loss of p24 antibodies during the study period was associated with progression to AIDS (p = 0.01) and thereby was an earlier prognostic parameter of a poor prognosis than T4 cell count. Neither changes in antibody patterns against other HIV polypeptides, HIV titers in the immunofluorescence test nor demonstration of HIV antigen were significantly associated with progression to AIDS. Cytomegalovirus (CMV) could be isolated from two duodenal biopsies of a patient who developed AIDS at the same time, but a concomitant serological diagnosis of CMV infection was not successful. Though signs in the serology of human herpesviruses (herpes simplex virus, CMV, Epstein-Barr virus), possibly indicating a reactivation of latent infections, could be observed in some instances, a correlation with clinical symptoms or the clinical outcome was not feasible, perhaps also because of a poor standardization of some of the test kits used. All patients were positive for IgG antibodies against the three herpesviruses when entering the study. High prevalence of hepatitis B virus (HBV) markers was found (83% anti-HBc positive), only 1 patient being chronically infected and highly infectious, as shown by HBV-DNA hybridization. No significant difference between treatment and placebo group was observed with the parameters tested in this study.

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Flow cytometric evaluation of the cytotoxicity of novel antiviral compounds

Nassiri

Hudson²,

Pudlo

et al. 1990

Cytometry

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Two acyclic analogs of bromotubericidin were tested for cytotoxic effects on uninfected cells by monitoring cell growth and measuring cell cycle perturbations using flow cytometry. As reported elsewhere, 5‐bromotubercidin analogs in which ribose was replaced by 2‐hydroxyethoxymethyl (compound 102) or by 1,3‐dihydroxypropoxymethyl (compound 183) were potent inhibitors of human cytomegalovirus (HCMV) replication in vitro (Pudlo et al.: Journal of Medicinal Chemistry 31:2086–2092, 1988). Because these compounds also inhibited the growth of uninfected cells, we performed kinetic studies with an established neoplastic line of human cells (KB) using flow cytometry. Growth of KB cells treated with either compound 102 or 183 were inhibited in a dose‐dependent manner. Growth inhibition by compound 183, however, was not fully expressed for at least 24 h. DNA analysis by flow cytometry showed that a 4‐h incubation with 10 μM compound 102 caused a decrease of cells in G2/M phase. Cells began to accumulate in early S phase by 12 h of incubation, leading to mid S phase accumulation at 21 h. Compound 183 at 10 μM slightly decreased the number of cells in G2/M phase after a 4‐h incubation, and led to accumulation of DNA in S phase after a 12‐h incubation. By 24 and 30 h, DNA histograms appeared similar to those of control cells but with a slight accumulation of the population in early S phase. In separate experiments, drugs were removed following a 24‐h incubation. After removal of compound 102, KB cell growth resumed with a normal population doubling time. In contrast, the effects of compound 183 were not reversible, suggesting the two compounds acted by different biochemical mechanisms.

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Cytomegalovirus infection in HIV-1-infected individuals

Cited by 16 publications

References 14 publications

Oral infections due to Cytomegalovirus in immunocompromised patients

Oral infections due to Cytomegalovirus in immunocompromised patients

Virological Examinations of Patients with AIDS-Related Complex/Walter-Reed 5 Enrolled in a Double-Blind Placebo-Controlled Study with Intravenous Gammaglobulin Administration

Flow cytometric evaluation of the cytotoxicity of novel antiviral compounds

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