Cytomegalovirus Infection in Early Infancy: Five Atypical Cases

The association between late-onset keratitis in congenital cytomegalovirus infection: A nationwide population-based cohort study

“…A previous case report showed co-existing of keratitis in a neonatal case with generalized CMV infection, 20 and another study revealed the bilateral central corneal opacities in congenital CMV infection. 21 In this study, the incidence rate of late-onset keratitis is significantly higher in congenital CMV infection population than those without such circumstance. This may be a preliminary finding to reveal the possible association between the congenital CMV infection and subsequent keratitis.…”

A Neonate with Bilateral Corneal Opacities and Glaucoma

“…The pathophysiology behind these corneal opacities in neonates has not been described in any of the published case reports. [4][5][6] Corneal endotheliitis resulting from the destruction of endothelium by CMV is a probable explanation for the opacities seen in our patient. The role of an infectious virus as the cause of the endothelial infection is supported first by detection of viral antigen, viral DNA, or viral particles in the corneal endothelial cells.…”

Cytomegalovirus infection presenting as acute haemolytic anaemia in an infant.

“…CMV infection, if congenital, commonly presents either as a glandular fever-like syndrome with hepatosplenomegaly, or as disease of the central nervous system with microcephaly and mental retardation (Weller and Hanshaw, 1962). Except in the neonatal period (Emanuel and Kenny, 1966;McEnery and Stern, 1970), acute haemolytic anaemia may be a rare presentation of acquired disease, one fatal adult case being reported by Coombs (1968) and 22 cases in children suggested by Zuelzer et al (1966), associated with lymphadenopathy, 7 of which had a fatal outcome.…”