Cytomegalovirus infection in a patient with atypical Kawasaki disease

Güç, Belgin Usta; Cengız, Nurcan; Yıldırım, Selman Vefa; Uslu, Yasemin

doi:10.1007/s00296-007-0440-4

Cited by 21 publications

(14 citation statements)

References 12 publications

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“…So far, no speci c pathogen has been con rmed to be absolutely associated with Kawasaki disease. Several case reports have linked Kawasaki disease with many pathogens such as Mycoplasma pneumoniae [26], cytomegalovirus [27], adenovirus, rhinovirus, enterovirus [28], bocavirus [29], parain uenza type 3 and coronavirus OC43/HKU1 [30]. Consistent with these reports, Kawasaki disease has been found to be associated with Mycoplasma pneumoniae, enterovirus, Epstein-Barr virus and adenovirus in our historical cohort and Mycoplasma pneumoniae and Epstein-Barr virus in our current cohort.…”

Section: Discussionsupporting

confidence: 90%

Kawasaki disease in pediatric isolation ward during COVID-19 pandemic

Xia¹,

Chen²,

Shu³

et al. 2020

Preprint

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Background: To our knowledge, a link between an emergence of Kawasaki disease and the ongoing COVID-19 pandemic has not been reported in China. Methods: This study retrospectively analyzed the clinical data of Kawasaki patients admitted to Maternal and Child Health Hospital of Hubei Province from January 1, 2015 to July 31, 2020. Kawasaki patients admitted to the isolation ward from January 1, 2020 to July 31, 2020 as the current cohort and Kawasaki patients admitted to the general wards from January 1, 2015 to December 31, 2019 as the historical cohort were analyzed.Results: The current cohort comprised 15 patients (10 boys and 5 girls, median age 11 months) without severe form. SARS-CoV-2 nucleic acid test was performed in 13 cases and SARS-CoV-2 antibodies (IgM and IgG) was conducted in 11 cases, but no positive results were found. The historical cohort included 89 patients (54 boys and 35 girls, median age 15 months). Comparison between the historical cohort and the current cohort demonstrated that there were no significant differences in age, sex, clinical manifestations, blood routine examination, blood biochemistry, cardiac ultrasound and treatment, but the incidence and the abnormal chest imaging in the current cohort were significantly higher than those in the historical cohort. Conclusion: This study suggested that there may be an association between the emergence of Kawasaki disease with non-severe form and COVID-19 pandemic in Wuhan.

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Section: Discussionsupporting

confidence: 90%

Kawasaki disease in pediatric isolation ward during COVID-19 pandemic

Xia¹,

Chen²,

Shu³

et al. 2020

Preprint

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“…However, many case reports have linked KD with many viral agents like Mycoplasma pneumoniae [41], Cytomegalovirus [42], adenovirus, rhinovirus, enterovirus [43], bocavirus [44]. …”

Section: Etiopathogenesismentioning

confidence: 99%

Kawasaki disease: etiopathogenesis and novel treatment strategies

Agarwal

Agrawal

2016

Expert Review of Clinical Immunology

146

113

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Introduction-Kawasaki disease is an acute febrile systemic vasculitis that predominantly occurs in children below five years of age. Its etiopathogenesis is still not clear, but it is thought to be a complex interplay of genetic factors, infections and immunity.Areas covered-This review article discusses in detail Kawasaki disease, with particular emphasis on the recent updates on its pathogenesis and upcoming alternate treatment options. Though self-limiting in many cases, it can lead to severe complications like coronary artery aneurysms and thrombo-embolic occlusions, and hence requires early diagnosis and urgent attention to avoid them. Intravenous immunoglobulin (IVIG) with or without aspirin has remained the sole treatment option for these cases, but 10-15% cases develop resistance to this treatment.Expert Commentary-There is a need to develop additional treatment strategies for children with Kawasaki disease. Targeting different steps of pathogenesis could provide us with alternate therapeutic options.

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“…In addition to SLE, CMV has been linked to other autoimmune diseases that occur in childhood including juvenile idiopathic arthritis [50], antiphospholipid antibody syndrome [51] and Kawasaki’s disease [52]. In contrast to SLE, in other autoimmune diseases CMV is most often detected at the time of disease flare instead of at presentation [21,53].…”

Section: And Slementioning

confidence: 99%

Cytomegalovirus infection in childhood-onset systemic lupus erythematosus

Rozenblyum¹,

Allen²,

Silverman³

et al. 2013

International Journal of Clinical Rheumatology

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Systemic lupus erythematosus (SLE) is a multisystem disease with significant morbidity and even mortality. Cytomegalovirus (CMV) is a ubiquitous herpesvirus that, similar to SLE, can also lead to significant morbidity and mortality in the immunocompromised host. The relationship between SLE and CMV is complex, with observations suggesting that CMV induces the autoimmunity of SLE in addition to occurring in the immunocompromised host with known SLE. In this article, we first consider CMV infection in the immunocompetent host, and further examine how this infection differs in the patient with SLE. We focus on disease mechanisms, CMV detection and treatment. We review the differences between CMV infection, syndrome and disease, as identifying the correct state will determine the appropriate treatment. We propose guidelines for the screening and management of CMV infection in childhood-onset SLE, and recognize that further study in this population is required to increase our understanding of the interplay between these disease entities.

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Cytomegalovirus infection in a patient with atypical Kawasaki disease

Cited by 21 publications

References 12 publications

Kawasaki disease in pediatric isolation ward during COVID-19 pandemic

Kawasaki disease in pediatric isolation ward during COVID-19 pandemic

Kawasaki disease: etiopathogenesis and novel treatment strategies

Cytomegalovirus infection in childhood-onset systemic lupus erythematosus

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Cytomegalovirus infection in a patient with atypical Kawasaki disease

Cited by 21 publications

References 12 publications

Kawasaki disease in pediatric&nbsp;isolation ward&nbsp;during COVID-19 pandemic

Kawasaki disease in pediatric&nbsp;isolation ward&nbsp;during COVID-19 pandemic

Kawasaki disease: etiopathogenesis and novel treatment strategies

Cytomegalovirus infection in childhood-onset systemic lupus erythematosus

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Kawasaki disease in pediatric isolation ward during COVID-19 pandemic

Kawasaki disease in pediatric isolation ward during COVID-19 pandemic