Cytomegalovirus Infection and Relative Risk of Cardiovascular Disease (Ischemic Heart Disease, Stroke, and Cardiovascular Death): A Meta‐Analysis of Prospective Studies Up to 2016

Wang, Haoran; Geng, Peng; Bai, Jing; He, Bing; Huang, Kecheng; Hu, Xinrong; Li, Dongliang

doi:10.1161/jaha.116.005025

Cited by 137 publications

(122 citation statements)

References 32 publications

Supporting

Mentioning

115

Contrasting

Unclassified

Order By: Relevance

“…Although the role of IL-17A in inflammatory disorders is well described [51], its involvement in vascular inflammation and atherosclerosis is less clear with conflicting reports [52][53][54][55]. The aforementioned findings may provide an additional mechanism that further implicate CMV in the development of cardiovascular disease [56], and warrants further investigation in a larger and more inclusive cohort.…”

Section: Discussionmentioning

confidence: 97%

Altered CD4+ T cell immunity in nurses occupationally exposed to viral pathogens

Souquette

Heynderickx

Meester

et al. 2018

Clinical and Experimental Immunology

View full text Add to dashboard Cite

Pathogen exposure, including but not limited to herpesviruses, moulds the shape of the immune system, both at a basal state and in response to immune challenge. However, little is known about the impact of high exposure to other viruses on baseline immune signatures and how the immune system copes with repetitive exposures to maintain a balanced functionality. Here we investigated baseline immune signatures, including detailed T cell phenotyping, antigen-specific CD4 and CD8 T cell responses and cytokine profile in paediatric (PED) nurses, who have high occupational exposure to viral pathogens including varicella zoster virus (VZV) and respiratory viruses, and in neonatal intensive care unit (NICU) nurses, as a control group with infrequent occupational exposure. Our results show a lower CD4 T cell response to two VZV proteins (IE62 and gE) and to tetanus toxoid (TT) in PED nurses who are cytomegalovirus (CMV)-seronegative, compared to CMV-seronegative NICU nurses, and that the decline might be more pronounced the more sustained the exposure. This decline might be due to an attrition of VZV- and TT-specific T cells as a result of the continuous pressure on the CD4 T cell compartment. Moreover, our data suggest that the distinct T cell phenotypes known to be associated with CMV-seropositivity might be less prominent in PED nurses compared to NICU nurses, implying a plausible attenuating effect of occupational exposure on CMV-associated immunosenescence. Overall, this pilot study reveals an impact of occupational exposure to viral pathogens on CD4 T cell immunity and supports further investigation in a larger cohort.

show abstract

Section: Discussionmentioning

confidence: 97%

Altered CD4+ T cell immunity in nurses occupationally exposed to viral pathogens

Souquette

Heynderickx

Meester

et al. 2018

Clinical and Experimental Immunology

View full text Add to dashboard Cite

show abstract

“…56 Evaluation of the immune response to cytomegalovirus infection initially did not reveal an effect of seropositivity to cytomegalovirus on the development of atherosclerosis. 13,14,57 However, the results of seroepidemiological studies were also controversial, with further studies that found a positive correlation between the increased titer of antibodies to cytomegalovirus and the development of atherosclerosis, [23][24][25]58,59 cardiovascular events, 60,61 and mortality, 62,63 even when adjusted to other traditional cardiovascular risk factors. These controversies in seroepidemiological studies as well as the low level of cytomegaloviral DNA found in atherosclerotic plaques and later in peripheral blood mononuclear cells of patients with cardiovascular diseases 64 could be explained by the occasional detection of the latent infection in these studies, rather than productive viral infection, whereas only the latter correlates with plaque destabilization.…”

Section: Discussionmentioning

confidence: 99%

Productive Cytomegalovirus Infection Is Associated With Impaired Endothelial Function in ST-Elevation Myocardial Infarction

Lebedeva

Maryukhnich

Grivel

et al. 2020

The American Journal of Medicine

View full text Add to dashboard Cite

BACKGROUND: An association between productive cytomegalovirus infection and atherosclerosis was shown recently in several trials, including a previous study of ours. However, the mechanism involved in this association is still under investigation. Here, we addressed the interaction between productive cytomegalovirus infection and endothelial function in patients with ST-elevation myocardial infarction (STEMI). METHODS: We analyzed the presence of cytomegaloviral DNA in plasma and endothelial function in 33 patients with STEMI and 33 volunteers without cardiovascular diseases, using real-time polymerase chain reaction (PCR) and a noninvasive test of flow-mediated dilation. RESULTS: Both the frequency of presence and the load of cytomegaloviral DNA were higher in plasma of patients with STEMI than those in controls. This difference was independent of other cardiovascular risk factors (7.38 [1.36-40.07]; P = 0.02). The results of the flow-mediated dilation test were lower in patients in STEMI than in controls (5.0% [2.65%-3.09%] vs 12. %5 [7.5%-15.15%]; P = 0.004) and correlated negatively with the cytomegaloviral DNA load (Spearman R = À0.407; P = 0.019) independently of other cardiovascular risk factors. CONCLUSIONS: Productive cytomegalovirus infection in patients with STEMI correlated negatively with endothelial function independently of other cardiovascular risk factors. The impact of cytomegalovirus on endothelial function may explain the role of cytomegalovirus in cardiovascular prognosis. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license. (http:// creativecommons.org/licenses/by-nc-nd/4.0/) The American Journal of Medicine (2020) 133:133−142

show abstract

“…Even though the relevant infectious agents of VD have not been studied more than those of AD, the stronger association of CMV disease with VD than AD in this study will be interesting finding. This result suggests that CMV may play a possible role in complex VD pathogenesis because active recurrent intermittent CMV replication and/or latent CMV infection status is associated with chronic inflammatory atherosclerosis, vascular damage, and ultimately, cerebrovascular/cardiovascular diseases (CVDs) [27,28].…”

Section: Discussionmentioning

confidence: 99%

Association Between Cytomegalovirus Disease and Dementia: A Population-Based Cohort Study

Lee¹,

Kwon²,

Han³

et al. 2019

Preprint

View full text Add to dashboard Cite

Background The association between human cytomegalovirus (CMV) and dementia remains controversial. Previous studies have suggested that CMV serostatus assessed by serum immunoglobulin G plays a role in neurodegeneration with cognitive impairment. We aimed to evaluate the association between CMV tissue-invasive diseases and vascular dementia (VD) and Alzheimer’s disease (AD).MethodsThe International Classification of Diseases (ICD) 10th revision codes from the National Health Insurance Database covering entire people in Republic of Korea were used to classify patients: case group (n = 687), age ≥40 years with CMV tissue-invasive end-organ disease and control group (n = 3,435), without CMV disease, matched by age and sex (ratio, 1:5). The case and control subjects selected during 2010–2014 with a washout period of the previous 4 years were followed-up until December 2016.ResultsThe multivariate regression model adjusted for age and sex showed a significantly higher incidence of dementia (odds ratio [OR], 2.1; 95% confidence interval [CI], 1.5–3.1) in the case group. The risk of VD (OR, 3.3; 95% CI, 1.3–8.4) was higher than that of AD (OR, 1.7; 95% CI, 1.1–2.8) in the case group. In age subgroup analysis adjusted for sex, patients aged 40–59 years with CMV disease had a significantly higher risk of all kinds of dementia than those aged 60-79 and ≥80 years (OR, 12.6; 95% CI, 3.3–48.8 vs. OR, 2.1; 95% CI, 1.3–3.4 vs. OR, 1.4; 95% CI, 0.7–2.9; P=0.021).Conclusions CMV disease may be associated with the risk of VD.

show abstract

Cytomegalovirus Infection and Relative Risk of Cardiovascular Disease (Ischemic Heart Disease, Stroke, and Cardiovascular Death): A Meta‐Analysis of Prospective Studies Up to 2016

Cited by 137 publications

References 32 publications

Altered CD4+ T cell immunity in nurses occupationally exposed to viral pathogens

Altered CD4+ T cell immunity in nurses occupationally exposed to viral pathogens

Productive Cytomegalovirus Infection Is Associated With Impaired Endothelial Function in ST-Elevation Myocardial Infarction

Association Between Cytomegalovirus Disease and Dementia: A Population-Based Cohort Study

Contact Info

Product

Resources

About