Cytomegalovirus Infection

Cytomegalovirus Infection Presenting as Severe Sepsis, Hepatitis, and Autoimmune Hemolytic Anemia in an Immunocompetent Child in Pediatric Intensive Care Unit

“…Acquired CMV infection is usually clinically inapparent in immunocompetent child and is rarely associated with complications. 1 This case presented with features of severe sepsis, progressive hepatitis with subsequent finding of AIHA posing a diagnostic challenge and CMV was considered as a possibility. There are reports of CMV causing warm AIHA and hepatitis in children.…”

A Robust Host-Response-Based Signature Distinguishes Bacterial and Viral Infections Across Diverse Global Populations

“…These viruses may be detected and have disease attributed to them even when they are not the causative agent of acute illness. 87,88 Across 37 retrospective and 2 prospective cohorts used for validation, the BoVI score has low negative likelihood ratios (<0.12), high positive likelihood ratios (R6.33), and high PPV and NPV (R83%). These test characteristics are substantially higher than other host-response-based diagnostics, 89 which suggest that it would be potentially effective as a rule-out and a rule-in test.…”

Antigen‐specific and cross‐reactive T cells in protection and disease

“…Persistent viral infections, such as Epstein–Barr virus (EBV) and cytomegalovirus (CMV), are common in the population. In health they generally pose no threat, but in the immunocompromised and in infants they can present serious problems 78,79 . Infection with persistent viruses have also been linked to autoimmune diseases, such as multiple sclerosis, 80,81 revealing their capacity to elicit aberrant immune programs.…”

“…In health they generally pose no threat, but in the immunocompromised and in infants they can present serious problems. 78,79 Infection with persistent viruses have also been linked to autoimmune diseases, such as multiple sclerosis, 80,81 revealing their capacity to elicit aberrant immune programs. The specific mechanisms of the observed immune aberrancy, however, remains unclear.…”