Cytomegalovirus-induced Colon Perforation in Systemic Lupus Erythematosus

Glushko, Tetiana; Marcus, Victoria; Colmegna, Inés

doi:10.3899/jrheum.150964

Cited by 4 publications

(3 citation statements)

References 8 publications

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“…Now after 1 year of follow-up, she is off steroid, on weekly methotrexate and is asymptomatic. While CMV colitis causing perforation has been previously reported in autoimmune diseases like SLE,20 21 to our knowledge, this is the first case of a child with JDM developing a CMV colitis which was further complicated by a perforation.…”

Section: Discussionmentioning

confidence: 62%

Unusual cause for intestinal perforation in juvenile dermatomyositis

Bhaskaran

Balan²

2019

BMJ Case Rep

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We report a case of juvenile dermatomyositis (JDM) with cytomegalovirus (CMV) colitis which was further complicated with perforation. The patient, a 6-year-old girl, was diagnosed with JDM 1 month prior to the current presentation. After 2 weeks of optimising her treatment with steroid, intravenous Ig and methotrexate, she was readmitted with diffuse abdominal pain. Erect abdominal X-ray revealed gas under diaphragm. An exploratory laparotomy showed perforation of the large intestine. A biopsy showed inclusion bodies of CMV with immunohistochemistry for CMV positive. Strong positive CMV DNA PCR from tissue specimen, positive IgG CMV and negative IgM CMV in blood suggested a reactivation of CMV. The treatment followed included surgery and strategic use of antiviral agents as well as immunomodulators. CMV enteritis with complications should also be suspected in optimally treated autoimmune disease patients, including JDM, when they present with abdominal symptoms.

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Section: Discussionmentioning

confidence: 62%

Unusual cause for intestinal perforation in juvenile dermatomyositis

Bhaskaran

Balan²

2019

BMJ Case Rep

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“…Высказано предположение о связи между инфицированием H. pylori и аутоиммунными/гематологическими нарушениями при системных ревматических заболеваниях [18,19]. Кроме того, в настоящее время активно обсуждается возможное участие вирусов семейства Herpesviridae в развитии активного гастрита, язвенных дефектов и геморрагий СОЖ, особенно на фоне иммунодефицита или прове-дения иммуносупрессивной терапии [20][21][22][23][24]. Цель исследования -определить роль H. pylori, вирусов семейства Herpesviridae (часть I) и лекарственных препаратов (часть II) в развитии повреждений СОЖ при СКВ и АФС.…”

Section: Introductionunclassified

Damage to the Gastric Mucosa in Patients with Systemic Lupus Erythematosus and Antiphospholipid Syndrome. Part I: Significance and Frequency of Detection of Helicobacter pylori and Viruses of Herpesviridae Family

Reshetnyak¹,

Дорошкевич²,

Cheldiyeva³

et al. 2020

EPh

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“…It has been suggested that there is a relationship between H. pylori infection and autoimmune and hematological disorders in systemic rheumatic diseases [22, 23]. In addition, whether the viruses of the Herpesviridae family can be involved in the development of active gastritis, GM ulcerous defects, and hemorrhages, particularly in patients on immunosuppressive therapy or in those with immunodeficiency, is being actively discussed now [24–28].…”

Section: Introductionmentioning

confidence: 99%

The Contribution of Drugs and Helicobacter pylori to Gastric Mucosa Changes in Patients with Systemic Lupus Erythematosus and Antiphospholipid Syndrome

Reshetnyak

Дорошкевич

Середавкина

et al. 2019

International Journal of Rheumatology

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Background. The nature and rate of gastric mucosal (GM) damage in systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) remain to be among the unsolved problems. Objective. To define the role of H. pylori and drugs in the development of GM damages in SLE and APS. Methods. A study was conducted on 85 patients with SLE and APS. All the patients underwent esophagogastroduodenoscopy with targeted biopsy of the mucosa of the gastric body and antrum. The presence of H. pylori in the gastric biopsy specimens was determined using polymerase chain reaction. Results. Endoscopic examination revealed that the patients with SLE and APS on admission had the following GM changes: antral gastritis (82.4%), erosions (24.7%), hemorrhages (8.2%), and pangastritis (8.2%). SLE and APS patients showed no direct correlation between the found GM damages and the presence of H. pylori. The use of glucocorticoid, low-dose acetylsalicylic acid, nonsteroidal anti-inflammatory drug, and anticoagulant in SLE and APS patients is accompanied by GM damage. Conclusion. There was no evidence of the role of H. pylori in GM damage in the SLE and APS patients. More frequent detection of H. pylori was observed in anticoagulants or low-dose acetylsalicylic acid users than in glucocorticoids and nonsteroidal anti-inflammatory drugs ones.

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Cytomegalovirus-induced Colon Perforation in Systemic Lupus Erythematosus

Cited by 4 publications

References 8 publications

Unusual cause for intestinal perforation in juvenile dermatomyositis

Unusual cause for intestinal perforation in juvenile dermatomyositis

Damage to the Gastric Mucosa in Patients with Systemic Lupus Erythematosus and Antiphospholipid Syndrome. Part I: Significance and Frequency of Detection of Helicobacter pylori and Viruses of Herpesviridae Family

The Contribution of Drugs and Helicobacter pylori to Gastric Mucosa Changes in Patients with Systemic Lupus Erythematosus and Antiphospholipid Syndrome

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