Cytomegalovirus in the normal pregnant woman

Hildebrandt, Richard J.; Sever, John L.; Margileth, Andrew M.; Callagan, Dwight A.

doi:10.1016/0002-9378(67)90038-5

Cited by 72 publications

(17 citation statements)

References 4 publications

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“…From 1 to 3% of all infants born in the United States have evidence of HCMV infection during the neonatal period (7,24). Although most of these infections are asymptomatic, approximately 10% of these infants will exhibit signs of visceral involvement during the neonatal period, and a significant number of these will subsequently develop abnormalities of the central nervous system (16).…”

mentioning

confidence: 99%

Effect of Cytosine Arabinoside and 5-Iodo-2′-Deoxyuridine on a Cytomegalovirus Infection in Newborn Mice

Kelsey

Kern²,

Overall³

et al. 1976

Antimicrob Agents Chemother

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Murine cytomegalovirus was inhibited by 0.6 to 1.2 ug of cytosine arabinoside per ml and by 0.3 to 0.6 ,ug of 5-iodo-2'-deoxyuridine in mouse embryo fibroblast cells. Human cytomegalovirus was inhibited by similar concentrations of the two drugs in WI-38 cells. Intraperitoneal inoculation of suckling mice with 104 5 plaque-forming units of murine cytomegalovirus provides a model for disseminated human cytomegalovirus infection in human newborn infants and is characterized by a widespread infection involving the liver, spleen, lung, kidney, and brain with a 70 to 90% mortality in 7 to 9 days. Treatment with 12.5 mg of cytosine arabinoside per kg or 25 mg of 5-iodo-2'-deoxyuridine per kg twice daily for 8 days had no effect on final mortality or the pathogenesis of the infection with the exception of reduced viral titers in the spleen of 5-iodo-2'-deoxyuridine-treated animals. These data indicate that neither cytosine arabinoside nor 5-iodo-2'-deoxyuridine are effective in the treatment of murine cytomegalovirus infections in suckling mice and suggest that they may be of limited value in the treatment of severe cytomegalovirus infections in human neonates.

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mentioning

confidence: 99%

Effect of Cytosine Arabinoside and 5-Iodo-2′-Deoxyuridine on a Cytomegalovirus Infection in Newborn Mice

Kelsey

Kern²,

Overall³

et al. 1976

Antimicrob Agents Chemother

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“…Since reactivating women possess preexisting circulating antibody intrauterine infection of the fetus does not occur and the baby is born healthy and uninfected. Others have also found that 2-3% of pregnant women excrete cytomegalovirus in the urine and on the cervix without infecting the fetus (Hildebrandt et al, 1967;Krech et al, 1968;Feldman, 1969;McCracken et al, 1969;Foy et al, 1970), though higher figures have been obtained for some Far Eastern countries (Alexander, 1967;Levinsohn et al, 1969). Continuing excretion of virus after term, however, perhaps in the throat and milk, provides a source of early infection for the infant once he has lost his maternal antibodies (Alexander, 1967;Stern, 1968;Levinsohn et al, 1969;Numazaki et al, 1970;Walker and Tobin, 1970); so far as is known these early postnatal infections are essentially benign.…”

Section: Discussionmentioning

confidence: 99%

Prospective Study of Cytomegalovirus Infection in Pregnancy

Stern¹,

Tucker²

1973

BMJ

206

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“…Hildebrand et al [23] have stud ied 210 postpartum women. Seven women were found to have CM V-positive urine and 1 neonate was infected [23]. In our study, this rate was 14.4% and CMV IgM positivity was seen in 3.4% of the babies.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Cytomegalovirus IgG and IgM Antibodies in the Sera of Postpartum Women and Cord Sera of Newborn Babies and Their Correlation with Socioeconomic Status

Fıçıcıoğlu¹,

Taşdemir²,

Gürbüz³

et al. 1996

Med Principles Pract

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Using the ELISA technique, cytomegalovirus (CMV) IgG and IgM values were measured in the sera of 176 subjects who delivered healthy term infants and in the cord sera of their newborn babies. IgG was positive in 149 of 176 maternal sera and in 6 of 176 newborn cord sera. The subjects were classified into three socioeconomic levels: high, moderate and low. The distribution of IgG and IgM positivity among the three groups revealed significant differences (p < 0.05). The fetus and the placenta are affected during primary and reactive infections in pregnancy. The percentage of IgM-positive infants delivered by IgM-positive patients was found to be highly significant. CMV IgG is not always protective against reinfection. In our study, IgM was positive in 24 women in spite of IgG positivity. The distribution of CMV seropositivity was not significantly different with regard to age and parity. CMV infection is an important risk factor in pregnancy as it is the most frequent congenital and early postnatal infectious agent.

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Cytomegalovirus in the normal pregnant woman

Cited by 72 publications

References 4 publications

Effect of Cytosine Arabinoside and 5-Iodo-2′-Deoxyuridine on a Cytomegalovirus Infection in Newborn Mice

Effect of Cytosine Arabinoside and 5-Iodo-2′-Deoxyuridine on a Cytomegalovirus Infection in Newborn Mice

Prospective Study of Cytomegalovirus Infection in Pregnancy

Prevalence of Cytomegalovirus IgG and IgM Antibodies in the Sera of Postpartum Women and Cord Sera of Newborn Babies and Their Correlation with Socioeconomic Status

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