Cytomegalovirus in Solid Organ Transplantation

Razonable, Raymund R.; Humar, Atul

doi:10.1111/ajt.12103

Cited by 466 publications

(434 citation statements)

References 91 publications

(179 reference statements)

Supporting

Mentioning

426

Contrasting

Unclassified

Order By: Relevance

“…[12] Furthermore, as in our case, some cases of compartmentalized or localized CMV diseases have very low or transient periods of viremia. [13,14] On the other hand, follow-up viral load testing is useful when the decision is made to initiate treatment, testing of the viral load should be performed the day the therapy starts, followed by viral load testing with 5-to 7-day intervals, because the half-life of CMV DNA in the plasma ranges from 3 to 8 days. [15] Antiviral drugs such as ganciclovir and foscarnet are the first-line treatment for clinically significant CMV infection.…”

Section: Discussionmentioning

confidence: 99%

A rare case of cytomegalovirus presentation in a hemodialysis patient

Waele

Wierckx

Bogaert³

2017

CRIM

View full text Add to dashboard Cite

Background: Cytomegalovirus (CMV) infection is a common viral infection in humans with a diverse manifestation, mostly dependent on the host. CMV infection in the immunocompetent host is generally asymptomatic or may present as a mononucleosis syndrome. Infection in immunocompromised patients cause substantial morbidity and mortality. Case representation: We report a rare manifestation of a CMV infection in a 87-year-old male with end-stage renal failure with dialysis dependency and diabetes who presents with diffuse abdominal pain and nausea. Further assessment with a CT scan of the abdomen showed a thickening of the wall of the preterminal ileum, suggestive of focal enteritis. Ileocolonoscopy showed a partial circular ulcerated mucosa of the preterminal ileum, biopsies showed ulcerations, etiology was unknown. A few days later he develops melena and anemia of 7.2 g/dl. Further exploration with gastroscopy was normal. A new colonoscopy showed no abnormalities; however the terminal ileum could not be visualized. An urgent laparotomy was performed because of hemodynamic instability and showed an ulcus of 7 cm with a thickened terminal ileum. An enterectomy of the inflammated part of the ileum was performed. Histopathology of the ulceration showed the presence of CMV inclusions in the vascular endothelium of the capillaires of the ileal segment. Serologic examination showed nonreactive CMV IgM antibodies and IgG antibodies were positive. PCR CMV showed 300 copies/ml (whole blood). Treatment with intravenous ganciclovir was started with good clinical and biochemical response. Conclusions: In the differential diagnosis CMV disease should be considered in any ulceration in the gastro-intestinal tract in the immunocompromised patient.

show abstract

Section: Discussionmentioning

confidence: 99%

A rare case of cytomegalovirus presentation in a hemodialysis patient

Waele

Wierckx

Bogaert³

2017

CRIM

View full text Add to dashboard Cite

show abstract

“…AP is the administration of antiviral drug to all "at-risk" patients for a defined period after solid organ transplant (SOT). PT is the administration of antiviral drug only to asymptomatic patients with evidence of early CMV replication in order to prevent CMV disease (5). Though a meta-analysis comparing the two strategies has already been performed (6), there were some limitations in the study.…”

Section: Introductionmentioning

confidence: 99%

Clinical Outcomes with Antiviral Prophylaxis or Preemptive Therapy for Cytomegalovirus Disease after Liver Transplantation: A Systematic Review and Meta-Analysis

et al. 2017

View full text Add to dashboard Cite

ABSTRACT-Objectives：We conducted a systematic review and meta-analysis to compare the clinical outcomes of patients after liver transplantation accepting antiviral prophylaxis (AP) or preemptive therapy (PT) for preventing cytomegalovirus (CMV) disease. Methods: A literature search of PubMed, Cochrane, Embase was conducted up to June 1, 2016. References of the retrieved articles were also reviewed and relevant studies were included. The primary outcomes were incidence of CMV infection, incidence of CMV disease, mortality and opportunistic infection. The second outcomes were the mean time to CMV infection and CMV disease, adverse drug reaction (ADR). Sensitivity analysis and publication bias were evaluated. Results: 6 cohort studies involving 1091 liver-transplant recipients (LTRs) were included. All studies were with high quality according to Newcastle-Ottawa Scales (NOS). Incidence of CMV infection and CMV disease showed significant difference between the AP and PT in high-risk patients. There was no significant difference of CMV-related mortality (725 patients, OR 1.27, 95%CI 0.12-13.47, p=0.84) and other opportunistic infections (311 patients, OR 0.85, 95%CI 0.49-1.45, p=0.55) in all "at-risk" patients between the two strategies, whereas late-onset CMV infection and CMV disease were found in patients receiving AP. Conclusion:We recommended the use of AP instead of PT in the high risk patients, and PT could be used in moderate or low risk patients for the similar clinical outcomes in preventing CMV disease. RCTs comparing the two strategies are warranted.

show abstract

“…CMV have minor symptoms may occur at the beginning, with weakness in immune system leads to the activity of the virus as a result of certain illnesses such as HIV AIDS virus or hepatitis virus type C or as a result of treatment with inhibitory drug therapy [1 ,9 ], organ transplants, especially kidney infection of cancers, diabetes, nephritis [10,11] Epidemiological studies showed that seroprevlance of CMV antibodies was a broad, and the presented rate of IgG antibodies to the virus ranges (30-97%), but the virus was lowest rate in Europe, Australia and some parts of North America, and high clearly in Africa, and the Middle East. [12,13].…”

Section: Introductionmentioning

confidence: 99%

Detection OF Cytomegalovirus Infection In Pre-Marital Women In Al-Khalis City

Ibrahim¹

2017

djps

View full text Add to dashboard Cite

The study group included 100 blood samples pre-marital women in Diyala / Al-Khalis, form the period from 1/10/2015 to 1/4/2016, the blood sample of women without any clinical evidence of cytomegalovirus (CMV) infection and free from infected by HIV .we were screened for the presence of IgG and IgM antibodies against CMV by strip test.The IgG antibodies were detected in 10%, while the IgM antibodies were detected in (6%). The sero negative (control) was (90%) for IgG and (94%) for IgM. Rising in seropositivity was observed in young women in age group (25-30years) for both IgG and IgM, Seroprevalence of CMV was more in women from urban area IgG (80%), IgM(83%) with no significant result. Most of the women have higher education rising to 90% for IgG and 100% for IgM.

show abstract

Cytomegalovirus in Solid Organ Transplantation

Cited by 466 publications

References 91 publications

A rare case of cytomegalovirus presentation in a hemodialysis patient

A rare case of cytomegalovirus presentation in a hemodialysis patient

Clinical Outcomes with Antiviral Prophylaxis or Preemptive Therapy for Cytomegalovirus Disease after Liver Transplantation: A Systematic Review and Meta-Analysis

Detection OF Cytomegalovirus Infection In Pre-Marital Women In Al-Khalis City

Contact Info

Product

Resources

About