Cytomegalovirus ileo-pancolitis presenting as toxic megacolon in an immunocompetent patient: A case report

Cho, Joon Hyun; Choi, Jung-Hwa

doi:10.12998/wjcc.v8.i3.552

Cited by 8 publications

(11 citation statements)

References 21 publications

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“…The current lower operative mortality for emergency surgery on AIDS patients (11% in one series) may be due to early intervention before colonic perforation ensues and active treatment at every level [10]. Also this case demonstrates that a colonic decompression and an appendicectomy plus post operative viral CMV treatment may suffice in treating CMV toxic colitis with megacolon [11,15]. Although gastrointestinal involvement with CMV infection is uncommon in immunocompetent patients, similar case reports on immunocompetent patients using a similar treatment approach except for appendicectomy yielded similar outcome [ 11,[15][16][17].The adjuvant treatment with HAART would improve the general resistance to infection and nutritionally status [18].…”

Section: Discussionmentioning

confidence: 92%

“…The patient benefited from an appendicectomy and sigmoidoscopic decompression of the toxic megacolon. The presumptive diagnosis of a CMV colitis complicating AIDS was corroborated by its response to post-operative anti-viral (acyclovir) treatment [11]. The morbidity and reported high 30 day mortality (71%) from an emergency sub-total colectomy and an ileostomy in these patients were avoided [12].…”

Section: Discussionmentioning

confidence: 99%

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A case of a toxic megacolon and acute appendicitis in HIV/ AIDS.

Weledji

Takere

Fon

2022

Preprint

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

A case of a toxic megacolon and acute appendicitis in HIV/ AIDS.

Weledji

Takere

Fon

2022

Preprint

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show abstract

“…The patient benefited from an appendicectomy and sigmoidoscopic decompression of the toxic megacolon. The presumptive diagnosis of a CMV colitis complicating AIDS was corroborated by its response to post-operative anti-viral (acyclovir) treatment [11]. The morbidity and reported high 30 day mortality (71%) from an emergency subtotal colectomy and an ileostomy in these patients were avoided [12].…”

Section: Discussionmentioning

confidence: 99%

A Case of Toxic Megacolon and Acute Appendicitis in HIV/AIDS

EP¹,

MM²,

P³

2022

austinjclincaserep

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“…Even though CMV colitis has been known to occur in immunocompromised hosts[ 6 ], recent studies suggested an increasing trend of CMV colitis in immunocompetent patients, especially with risk factors such as old age, renal failure, recent use of steroid or a recent history of blood transfusion[ 1 , 2 ]. However, in the current case, risk factors that may have affected the immune system such as underlying disease or a recent history of using immunosuppressant medication were not present.…”

Section: Discussionmentioning

confidence: 99%

Cytomegalovirus colitis induced segmental colonic hypoganglionosis in an immunocompetent patient: A case report

Kim

Park

Kim

et al. 2021

WJCC

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BACKGROUND Cytomegalovirus (CMV) colitis is usually seen in immunocompromised patients with risk factors such as human immunodeficiency virus infection, solid organ transplant, inflammatory bowel disease, or malignancy. Therefore, many clinicians usually do not consider the possibility of CMV colitis in immunocompetent patients. We reported a rare case of segmental colonic hypoganglionosis associated with CMV colitis in an immunocompetent patient. CASE SUMMARY A 48-year-old woman with no underlying disease was admitted to our hospital for severe abdominal pain and constipation. Computed tomography of the abdomen showed diffuse dilatation of the small intestine and the entire colon. Initial sigmoidoscopic findings and result of polymerase chain reaction (PCR) for CMV revealed the compatible findings of CMV colitis, the patient was treated with intravenous ganciclovir. After treatment, sigmoidoscopic findings and CMV PCR results improved. However the patient continued to suffered from constipation. Eight months after the initial admission, patient visited the emergency department with severe abdominal pain and imaging revealed aggravation of fecal impaction and bowel dilatation. We performed subtotal colectomy to control patient’s symptom. Histological examination of the resected specimen showed significantly reduced number of mature ganglion cells in the sigmoid colon compared to that in the proximal colon. CONCLUSION Our case demonstrates that CMV colitis can develop even in patients with no other underlying disease, and that CMV colitis can be one of the causes for developing colonic hypoganglionosis.

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Cytomegalovirus ileo-pancolitis presenting as toxic megacolon in an immunocompetent patient: A case report

Cited by 8 publications

References 21 publications

A case of a toxic megacolon and acute appendicitis in HIV/ AIDS.

A case of a toxic megacolon and acute appendicitis in HIV/ AIDS.

A Case of Toxic Megacolon and Acute Appendicitis in HIV/AIDS

Cytomegalovirus colitis induced segmental colonic hypoganglionosis in an immunocompetent patient: A case report

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