Cytomegalovirus Genotype Distribution among Congenital and Perinatal Infected Patients with CMV-Associated Thrombocytopenia

Hu, Hongping; Peng, Wenwen; Peng, Qiaoying; Cheng, Ying

doi:10.1080/15513815.2020.1765916

Cited by 5 publications

(7 citation statements)

References 20 publications

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“…As we reported earlier, the gH2 genotype was associated with at least a 7-fold increased risk of developing CMV-associated thrombocytopenia among infants with congenital and perinatal infections 4 . After including postnatal infection and non-thrombocytopenic cases into the analysis, similar conclusions were reached.…”

Section: Discussionsupporting

confidence: 73%

“…Our previous studies also confirmed that the gB1 genotype had more virulence in infants with symptomatic CMV disease. 3 , 4 …”

Section: Discussionmentioning

confidence: 99%

“…Our previous research revealed that there might be a potential association between the genotypes of CMV and neonatal thrombocytopenia, and the detection of some specific genotypes might be indicative of severe manifestations in infants with CMV infection. 3 , 4 However, the study design and the criteria to define the study population (congenital and non-congenital cases) and the setting of the control group (CMV-associated thrombocytopenia and non-thrombocytopenic cases) were not clearly established. For this reason, we included patients classified on more unambiguous criteria, and the clinical data collected were complete and thoroughly detailed, which allows us to assess the association between genotypes and the outcome in the non-congenital population.…”

Section: To the Editormentioning

confidence: 99%

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Cytomegalovirus genotype distribution among postnatally infected infants: association of glycoprotein B, glycoprotein N and glycoprotein H types with CMV-associated thrombocytopenia

Cheng

Peng³

et al. 2020

Mediterr J Hematol Infect Dis

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The aim of the present study was to identify the virulence of glycoprotein B (gB), glycoprotein N (gN), and glycoprotein H (gH) genotypes of cytomegalovirus(CMV) and assess possible relationships between genotypes and CMV-associated thrombocytopenia. CMV gB, gN, and gH strains were determined by nested PCR and restriction length polymorphism from 30 CMV-associated thrombocytopenia infants infected postnatally and 40 non-thrombocytopenic infants. The gN2 (p = 0.043) and gH2 (p = 0.038) genotypes were associated with an elevated risk of developing thrombocytopenia. gB1 genotype was detected in 80.0% (16/20) of infants with moderately to severely symptomatic CMV disease and was associated with severe manifestations in CMV-associated thrombocytopenia infants (p = 0.022). Conversely, the gN1 genotype was detected in 5.0% (1/20) of infants with moderately to severely symptomatic CMV disease and represent less pathogenic CMV strains (p = 0.044). There may be potential associations between the gN2 and gH2 genotypes of CMV and infantile thrombocytopenia, and that the detection of the gB1and gN1 genotypes may help define the severity of CMV disease in infants.

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Section: Discussionsupporting

confidence: 73%

“…Our previous studies also confirmed that the gB1 genotype had more virulence in infants with symptomatic CMV disease. 3 , 4 …”

Section: Discussionmentioning

confidence: 99%

Section: To the Editormentioning

confidence: 99%

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Cytomegalovirus genotype distribution among postnatally infected infants: association of glycoprotein B, glycoprotein N and glycoprotein H types with CMV-associated thrombocytopenia

Cheng

Peng³

et al. 2020

Mediterr J Hematol Infect Dis

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“…Currently, there is no consensus on the classification of HCMV strains based on genotype, evolutionary relationship, or clinical relevance [ 209 ]. Some authors have hypothesized that the genetic variation among HCMV strains may be the basis for specific clinical manifestations [ 210 , 211 , 212 ]. HCMV genomes sequenced directly from clinical material using high-throughput sequencing technology reveals variation, multiple-strain infection, recombination, and gene loss [ 213 ].…”

Section: Viruses Commonly Associated With Cns Infection In Brazilmentioning

confidence: 99%

Viral and Prion Infections Associated with Central Nervous System Syndromes in Brazil

Sousa

Santos

Paula

et al. 2021

Viruses

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Virus-induced infections of the central nervous system (CNS) are among the most serious problems in public health and can be associated with high rates of morbidity and mortality, mainly in low- and middle-income countries, where these manifestations have been neglected. Typically, herpes simplex virus 1 and 2, varicella-zoster, and enterovirus are responsible for a high number of cases in immunocompetent hosts, whereas other herpesviruses (for example, cytomegalovirus) are the most common in immunocompromised individuals. Arboviruses have also been associated with outbreaks with a high burden of neurological disorders, such as the Zika virus epidemic in Brazil. There is a current lack of understanding in Brazil about the most common viruses involved in CNS infections. In this review, we briefly summarize the most recent studies and findings associated with the CNS, in addition to epidemiological data that provide extensive information on the circulation and diversity of the most common neuro-invasive viruses in Brazil. We also highlight important aspects of the prion-associated diseases. This review provides readers with better knowledge of virus-associated CNS infections. A deeper understanding of these infections will support the improvement of the current surveillance strategies to allow the timely monitoring of the emergence/re-emergence of neurotropic viruses.

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“…1 Several envelope glycoproteins, encoded by UL55, UL73, and UL75, including glycoprotein B (gB), glycoprotein N (gN), and glycoprotein H (gH), respectively, have been evaluated in clinical CMV iso-lates because of their influence on tissue tropism and virulence. [2][3][4] The UL144 polymorphisms are concentrated in the 5′ end of the gene, especially in cysteine-rich domain 1 (CRD1), that may bind the B-and T-lymphocyte attenuator proteins. This domain's activity may vary among polymorphisms, leading to a range of clinical symptoms and prognoses.…”

Section: Introductionmentioning

confidence: 99%

Cytomegalovirus Genotype and Virulence in Infants with Congenital Infection

Hu¹,

Jian-gang²,

Sun³

et al. 2021

Journal of Pediatric Infectious Diseases

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Objective Cytomegalovirus (CMV) virulence may depend on genetic variability in several regions of the genome. This study aimed to assess specific CMV genotypes' association with the severity of symptomatic congenital CMV disease at birth. Methods CMV glycoprotein B (gB), glycoprotein N (gN), glycoprotein H (gH), and UL144 strains were identified by nested polymerase chain reaction, restriction fragment length polymorphism, and heteroduplex mobility assay single-stranded conformation polymorphism in 50 infants infected congenitally and 25 asymptomatic infants. Results gN1 (p = 0.010) and UL144-B (p = 0.034) genotypes were associated, by logistic regression, with reduced risk of developing symptomatic congenital CMV infection. gN1 (p = 0.020) and gN3 (p = 0.022) genotypes were associated with reduced risk of severe symptomatic disease. Conversely, gB1 (p = 0.018) was the most virulent genotype and was associated with severe symptoms. Conclusion An association among gB1, gN1, gN3, and UL144-B genotypes of CMV and severity of congenital CMV disease might exist. gB, gN, and UL144 genotypes could be important virological markers of infant infection.

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Cytomegalovirus Genotype Distribution among Congenital and Perinatal Infected Patients with CMV-Associated Thrombocytopenia

Cited by 5 publications

References 20 publications

Cytomegalovirus genotype distribution among postnatally infected infants: association of glycoprotein B, glycoprotein N and glycoprotein H types with CMV-associated thrombocytopenia

Cytomegalovirus genotype distribution among postnatally infected infants: association of glycoprotein B, glycoprotein N and glycoprotein H types with CMV-associated thrombocytopenia

Viral and Prion Infections Associated with Central Nervous System Syndromes in Brazil

Cytomegalovirus Genotype and Virulence in Infants with Congenital Infection

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