Cytomegalovirus disease in nonimmunocompromised, human immunodeficiency virus-negative adults with chronic kidney disease

Chen, Yao Ming; Hung, Yuan‐Pin; Huang, Chien Fang; Lee, Nan Yao; Chen, Chiung Yu; Sung, Junne Ming; Chang, Chia Ming; Chen, Po‐Lin; Lee, Ching Chi; Wu, Yi Hui; Lin, Hsiao Ju; Ko, Wen Chien

doi:10.1016/j.jmii.2013.01.011

Cited by 51 publications

(11 citation statements)

References 16 publications

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“…In our patient, other types of colitis (such as ischemic colitis, collagenous colitis or ulcerative colitis) were also suspected. The colonoscopic findings of CMV colitis are various and include various lesions, such as a solitary ulcer, multiple ulcers, ischemic colitis, polypoid lesions, pseudomembranous colitis-associated lesions and rectal ulcer (8)(9)(10)(11)(12)(13). A previous case report described an ulcerated stricture caused by CMV colitis (27).…”

Section: Discussionmentioning

confidence: 99%

“…The diagnosis of CMV colitis might be complicated as it may mimic the symptoms of other diseases (7). The reported colonoscopic findings of CMV colitis include various lesions such as a solitary ulcer, multiple ulcers, ischemic colitis, polypoid lesions, and pseudomembranous colitis-associated lesions (8)(9)(10)(11)(12). When investigations into the etiology of acute hemorrhagic rectal ulcers are performed, physicians should exclude other diseases such as CMV colitis (13,14).…”

Section: Introductionmentioning

confidence: 99%

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Cytomegalovirus Colitis in a Critically Ill Patient Following Severe <i>Legionella</i> Pneumonia with Multiple Organ Failure

et al. 2016

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A 68-year-old man visited an emergency department complaining of dyspnea. He was diagnosed to have Legionella pneumonia with multiple organ failure. Although his multiple organ failure improved, he suffered from persistent abdominal pain and diarrhea with continuous minor bleeding. Colonoscopy revealed a longitudinal ulcer of the rectum, below the peritoneal reflection. He was diagnosed with cytomegalovirus (CMV) colitis. Antiviral therapy with ganciclovir was initiated. He finally underwent a colostomy after a bowel stricture caused an intestinal outlet obstruction, which made oral intake impossible. Based on the present case, we believe that CMV colitis must be considered as one of the differential diagnoses when critically ill patients develop continuous diarrhea and abdominal pain.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cytomegalovirus Colitis in a Critically Ill Patient Following Severe <i>Legionella</i> Pneumonia with Multiple Organ Failure

et al. 2016

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“…Mucosal erythema, friability, and ulcers occur throughout the gastrointestinal tract. Esophageal ulcers are more common distally and usually have discrete borders, but they can be confluent and span up to 10 cm [52]. CMV rarely elicits an exuberant inflammatory reaction that simulates malignancy [53].…”

Section: Hiv and Aidsmentioning

confidence: 99%

Inflammatory and infectious manifestations of immunodeficiency in the gastrointestinal tract

Panarelli

Yantiss

2018

Modern Pathology

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Immune compromise may result from genetic abnormalities, HIV/AIDS, or consequences of therapy for neoplastic and autoimmune diseases. Many immunocompromised patients develop severe gastrointestinal symptoms, particularly diarrhea, accompanied by non-specific or mild endoscopic abnormalities; mucosal biopsy with pathologic interpretation has a major role in the diagnosis and management of these patients. Immunocompromised individuals are at risk for all the diseases that affect those with a healthy immune system, but they are also prone to other illnesses that rarely affect immunocompetent patients. This review discusses the gastrointestinal manifestations of primary and acquired immunodeficiency, chemotherapy-related injury, and infections that show a predilection for immunocompromised patients. Key histologic features and relevant differential diagnoses are emphasized.

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“…It has also been reported in patients with steroid dependency or chronic renal failure [2,3]. In immunocompetent patients it is usually asymptomatic and does not require treatment.…”

Section: Introductionmentioning

confidence: 97%

Conservative treatment of cytomegalovirus colitis with bowel perforation in an immunocompetent patient: case report and review of literature

Nam

Park

et al. 2017

Yeungnam Univ J Med

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Cytomegalovirus (CMV) colitis, which is rare in an immunocompetent patient, was encountered in a 67-yearold man who was admitted due to persistent diarrhea. The first diagnostic tool was colonoscopy, which showed multiple ulcers from cecum to rectum. The secondary tool was CMV polymerase chain reaction, and CMV colitis was diagnosed. Intravenous ganciclovir therapy was administered, which resulted in improvement of diarrhea and ulcers throughout the colon were healed. Asymptomatic colon perforation was detected during diagnostic testing, which improved over the conventional treatment. CMV colitis is rare in immunocompetent patients, but it is essential for the differential diagnosis.

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Cytomegalovirus disease in nonimmunocompromised, human immunodeficiency virus-negative adults with chronic kidney disease

Abstract: CMV disease may occur in CKD patients without the presence of overt immunodeficiency. The gastrointestinal tract is the most common site of involvement. Clinicians should be aware of this possibility in CKD patients who have GI symptoms.

Cited by 51 publications

References 16 publications

Cytomegalovirus Colitis in a Critically Ill Patient Following Severe <i>Legionella</i> Pneumonia with Multiple Organ Failure

Cytomegalovirus Colitis in a Critically Ill Patient Following Severe <i>Legionella</i> Pneumonia with Multiple Organ Failure

Inflammatory and infectious manifestations of immunodeficiency in the gastrointestinal tract

Conservative treatment of cytomegalovirus colitis with bowel perforation in an immunocompetent patient: case report and review of literature

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