Cytomegalovirus Disease in HIV-infected Children—A Single-Centre Clinical Experience over 23 Years

Suri, Deepti; Jindal, Ankur Kumar; Gupta, Aman; Gupta, Anju; Bajgai, Priya; Singh, Ramandeep; Singh, Mini P.; Minz, Ranjana W.; Arora, Sunil; Singh, Surjit

doi:10.1093/tropej/fmx052

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Cited by 4 publications

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“…In contrast to old age, the architecture, stability and composition of the TCR repertoire in infancy remains poorly understood due to the scarcity of deep sequencing studies conducted with paediatric samples ( 28 , 29 ). Several small-scale studies have looked at the composition of the foetal repertoire ( 30 ), although very few were carried out at the deep sequencing level ( 20 ).…”

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confidence: 99%

Cytomegalovirus-Mediated T Cell Receptor Repertoire Perturbation Is Present in Early Life

et al. 2020

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TCR-β chain, where oligoclonality was low in children and positively correlated with age, a feature we did not observe for TCR-α. This discrepancy between TCR-α and-β chain repertoire may reflect differential contribution to NW8 recognition. Altogether, the results of the present study provide insight into the formation of the TCR repertoire in early life and pave the way to better understanding of CD8 T cell responses to CMV at the molecular level.

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