Cytomegalovirus (CMV) encephalomyeloradiculitis and human immunodeficiency virus (HIV) encephalitis: presence of HIV and CMV co-infected multinucleated giant cells

Bélec, Laurent; Gray, Françoise; Mikol, J; Salvatore, Francesco; Mhiri, Chokri; Sobel, Alain; Poirier, Jacques

doi:10.1007/bf00662645

Cited by 46 publications

(15 citation statements)

References 28 publications

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“…CMV frequently disseminates to the CNS in late stages of HIV infection when the CD4 ϩ -T-cell count is low (19,20). CMV is also purported to be a cofactor in AIDS dementia syndrome and can infect the same cells as HIV (5,34,39,49). Clinical manifestations of neurotropic CMV infection of mature CNS may include retinitis, encephalitis, myeloradiculitis, subcortical dementia, obtundation, and other significant neurological deficits, with potentially fatal outcomes (1,3,14,21,33,34,39,49,51).…”

mentioning

confidence: 99%

Systemic Immune Deficiency Necessary for Cytomegalovirus Invasion of the Mature Brain

Reuter¹,

Gomez²,

Wilson³

et al. 2004

J Virol

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mentioning

confidence: 99%

Systemic Immune Deficiency Necessary for Cytomegalovirus Invasion of the Mature Brain

Reuter¹,

Gomez²,

Wilson³

et al. 2004

J Virol

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“…These cells have been described in the brain (Nelson et al, 1988), in the retina (Skolnik et aI., 1989), in the lungs (Finkle et al, 1991) and in monocytemacrophages (Belec et al, 1990). Given that there are several different types of cells in which co-infection has been found, as well as the acknowledged insensitivity of histopathological techniques, it therefore seems plausible that CMV and HIV co-infection may occur frequently in those with AIDS.…”

Section: Autopsy Resultsmentioning

confidence: 96%

A Proposal that Herpesviruses are Co-Factors of HIV Disease

Griffiths

1995

Antivir Chem Chemother

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SummaryThere is now extensive evidence that herpesviruses can interact with human immunodeficiency virus (HIV) in vitro. To determine if such interactions could be operative in vivo, evidence from AIDS autopsy series are reviewed. Using basic histopathological techniques, cytomegalovirus (CMV) and HIV coinfection of various individual cet'G has been demonstrated. Using cell culture, CMV has been detected ln 66% and herpes simplex virus in 11% of patients. Using immunocytochemistry, human herpesvirus type 6 (HHV-6) has been found in virtually all tissue sections. The hypothesis that these viruses contribute to the death of individuals with AIDS is supported by the results of two double-blind, placebocontrolled randomized trials of high-dose aciclovir and an observational study of the same drug. All three studies have shown improved survival. Thus, the case is made that herpesviruses act as co-factors of HIV disease, and that inhibition of such infections represents a potential way of reducing mortality in those with AIDS. This paper was presented as the case for in a debate on 'Herpesviruses as co-factors of HIV disease'. The case against was made by Don Jeffries (see page 22).

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“…To date, CMV has been examined and co-infection of cells from retina, brain and lungs has been identified (Belec et al, 1990 ;Finkle et al, 1991 ;Nelson et al, 1988 ;Skolnik et al, 1989).…”

Section: Prevalence Of Herpesviruses In Autopsy Tissuementioning

confidence: 99%

Studies of viral co-factors for human immunodeficiency virus in vitro and in vivo.

Griffiths

1998

Journal of General Virology

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Cytomegalovirus (CMV) encephalomyeloradiculitis and human immunodeficiency virus (HIV) encephalitis: presence of HIV and CMV co-infected multinucleated giant cells

Cited by 46 publications

References 28 publications

Systemic Immune Deficiency Necessary for Cytomegalovirus Invasion of the Mature Brain

Systemic Immune Deficiency Necessary for Cytomegalovirus Invasion of the Mature Brain

A Proposal that Herpesviruses are Co-Factors of HIV Disease

Studies of viral co-factors for human immunodeficiency virus in vitro and in vivo.

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