Cytomegalovirus-associated gastric ulcers in a patient with dermatomyositis treated with steroid and cyclophosphamide pulse therapy

Hoshino, Kunikazu; Shibata, Darryl; Miyagi, Takuya; Yamamoto, Yoshimasa; Arakaki, Shingo; Maeshiro, Tsuyoshi; Hokama, Akira; Kinjo, Fukunori; Takahashi, Keiko; Fujita, Jiro

doi:10.1055/s-0030-1256422

Cited by 8 publications

(5 citation statements)

References 4 publications

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“…It is the commonest IIM [ 2 ] and affects women more frequently than men. Although the cause is not well known, it has been described to be associated with malignancies [ 3 , 4 ], previous viral infections [ 5 , 6 ] and autoimmune diseases [ 7 ], of which systemic lupus erythematosus (SLE) and Sjögren's syndrome are the most frequently observed. Renal involvement typically consists of acute tubular injury due to myoglobinuria secondary to rhabdomyolysis.…”

Section: Discussionmentioning

confidence: 99%

Overlap between dermatomyositis and ANCA vasculitides

Yuste

Rapalai

Pritchard

et al. 2013

Clinical Kidney Journal

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We present the second report of the association between antineutrophil cytoplasm antibodies (ANCA)-associated vasculitis with dermatomyositis (DM). A 47-year-old woman suddenly developed rapidly progressive renal failure in the context of (DM). The kidney biopsy showed focal and segmental necrotizing glomerulonephritis with crescent formation. Cyclophosphamide treatment was commenced resulting in a significant recovery of kidney function and maintenance of recovery at 6 months. Although the pathophysiology is unknown, we hypothesize that CD8-T-deficient cells and MPO+ neutrophils in the DM lesions play an important role in the disease process.

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Section: Discussionmentioning

confidence: 99%

Overlap between dermatomyositis and ANCA vasculitides

Yuste

Rapalai

Pritchard

et al. 2013

Clinical Kidney Journal

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“…In general, it is recognized that CMV-associated GDU is caused mostly in immunocompromised patients, especially patients receiving immunosuppressive therapies. 8 , 9 Alternatively, there are several reports of CMV-associated GDU developed in immunocompetent patients. 10 – 13 However, since their precise immune conditions were not fully examined, they might have been in immunocompromised settings.…”

Section: Discussionmentioning

confidence: 99%

Cytomegalovirus-Associated Gastroduodenal Ulcers in a Patient With Functional Hypercortisolism

Iizuka

Chen

Tominaga³

et al. 2015

Medicine

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Cytomegalovirus (CMV)-associated gastroduodenal ulcers (GDU) are a rare digestive disease, which principally affect immunocompromised patients. We recently experienced CMV-associated GDU occurring in a seemingly immunocompetent patient. The rarity of such a condition was inimical to a correct clinical diagnosis.A 77-year-old woman with Alzheimer's disease was admitted to our hospital because of vomiting and anorexia. Her general condition was extremely poor due to severe dehydration. Any invasive procedures including gastroduodenal endoscopy could not be performed. Laboratory test results showed electrolyte imbalance, hyperglycemia, and hypercortisolemia. The plasma adrenocorticotropic hormone level was rather low. On her 11th day in hospital, she suddenly fell into shock status. Despite intensive care, the patient could not be rescued. An autopsy was performed and revealed that she had suffered from CMV-associated GDU and died of candidemia that invaded through the ulcer. Her adrenal glands showed neither neoplasm nor hyperplasia, suggesting that her hypercortisolism was a purely functional disorder. We concluded that the severe opportunistic infections were developed in association with functional hypercortisolism.This case suggests that functional hypercortisolism, even though transient, can cause a patient to be immunocompromised.

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“…Gastric and duodenal damage in HIV-infected patients. HIV infection is associated with marked chronic inflammation of the gastric mucosa, a decrease in acid secretion and increased gastric pH during fasting 27,28 . Extensive studies were performed on the evolution of the H. pylori infection associated with HIV infection.…”

Section: Statistical Significance (Ci 95%)mentioning

confidence: 99%

The utility of upper digestive endoscopy in the evaluation of HIV patients with low CD4+ T-lymphocyte values

Olariu¹,

Vasilescu²,

Nurciu³

et al. 2019

Arch Balk Med Union

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L'utilité de l'endoscopie digestive haute dans l'évaluation des patients avec VIH aux valeurs basses de lymphocytes T CD4+ Introduction. Le tube digestif est invariablement affecté chez les patients infectés par le VIH et doit être étudié en particulier chez les patients présentant une maladie de plus longue durée. L'importance de la diminution du nombre de cellules CD4 + en tant que facteur prédictif de l'existence et de la gravité des lésions du tractus gastro-intestinal supérieur a déjà été évaluée dans le cadre de certaines études démontrant qu'il existe un lien entre ce paramètre et la fréquence ou l'étendue des lésions oesophagiennes ou gastriques. L'objectif de l'étude était d'étudier les infections du tractus digestif supérieur chez les patients infectés par le VIH et d'établir le lien entre les modifications endoscopiques (type et localisation) et le nombre de cellules CD4 + périphériques.

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Cytomegalovirus-associated gastric ulcers in a patient with dermatomyositis treated with steroid and cyclophosphamide pulse therapy

Cited by 8 publications

References 4 publications

Overlap between dermatomyositis and ANCA vasculitides

Overlap between dermatomyositis and ANCA vasculitides

Cytomegalovirus-Associated Gastroduodenal Ulcers in a Patient With Functional Hypercortisolism

The utility of upper digestive endoscopy in the evaluation of HIV patients with low CD4+ T-lymphocyte values

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