Cytomegalovirus-associated Acute Retinal Necrosis Syndrome

Silverstein, Bruce E.; Conrad, Diana; Margolis, Todd P.; Wong, Ira G.

doi:10.1016/s0002-9394(14)71046-3

Cited by 44 publications

(16 citation statements)

References 4 publications

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“…In the third patient, although he was HIV negative, he presented with a six-week history of signs and symptoms of disseminated CMV infection causing prolonged fever, hepatosplenomegaly, and gastric ulcers before the retina was affected [5]. The fourth patient was immunocompromized because of diabetes and being on immunosuppressive drugs such as prednisolone and azathioprine for his interstitial pulmonary fibrosis illness [6]. The fifth and sixth patients had prior ocular pathology that needed use of steroids, either intravitreally or orally, before the CMV retinitis developed [7,8].…”

Section: Discussionmentioning

confidence: 99%

“…We present a case of CMV-related ARN in an immunocompetent healthy adult highlighting the unusual dual combination, which is uncommon in daily ophthalmic practice. We also reviewed the literature of CMV ocular infections in immunocompetent adults [3][4][5][6][7][8][9][10][11], to examine the different presentations of this disease. eye for ten days.…”

Section: Introductionmentioning

confidence: 99%

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Acute retinal necrosis by cytomegalovirus in an immunocompetent adult: case report and review of the literature

2007

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A rare case of acute retinal necrosis caused by cytomegalovirus in an immunocompetent adult, diagnosed by polymerase chain reaction of vitreous aspirate, with good visual outcome after intravitreal and intravenous ganciclovir and oral prednisolone therapy, is reported. A 50-year-old healthy lady presented with redness and diminution of vision in her right eye of 10 days duration. She had anterior chamber inflammation, marked vitritis, and anterior retinal necrosis in the right eye. Blood and other investigations did not reveal any infectious diseases and HIV testing was negative. The retinal lesions and panuveitis resolved with treatment. Two months later she developed retinal detachment which was treated successfully. The best-corrected vision was 6/12 in the right eye. Seven cases of cytomegalovirus ocular infection in immunocompetent healthy adults, reported in the literature, were reviewed. The different presentations of this disease and the importance of suspecting this causative agent are highlighted.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Acute retinal necrosis by cytomegalovirus in an immunocompetent adult: case report and review of the literature

2007

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“…CMV as the causative agent of a viral retinitis in absence of immunsuppressive therapy in immunocompetent patients is extremely rare. To our knowledge, only four such cases were documented in the literature (Silverstein et al, 1997;Tajunisah et al, 2009;Urayama et al, 1971;Voros et al, 2006). The controversial role of EBV for ARN was investigated in a case control study (Ongkosuwito et al, 1998).…”

Section: Epidemiologymentioning

confidence: 99%

Virus Diagnostics and Antiviral Therapy in Acute Retinal Necrosis (ARN)

Rautenberg¹,

Hillenkamp²,

Grancicova³

et al. 2012

Antiviral Drugs - Aspects of Clinical Use and Recent Advances

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“…Acute Retinal Necrosis (ARN) is a type of retinitis that affects both healthy and immunocompromised patients (86). This inflammatory disease is caused by several members of the herpesvirus family including herpes simplex virus (HSV-1), varicela zoster virus (VZV) and citomegalovirus (CMV) (87,88).…”

Section: Ophthalmic Infectionsmentioning

confidence: 99%