Cytomegalovirus antibody status at 17–18 weeks of gestation and pre‐eclampsia: a case–control study of pregnant women in Norway

Strand, Kristin Melheim; Odland, Maria Lisa; Iversen, Ann‐Charlotte; Nordbø, Svein Arne; Vik, Torstein; Austgulen, Rigmor

doi:10.1111/j.1471-0528.2012.03420.x

Cited by 16 publications

(15 citation statements)

References 39 publications

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“…In a Chinese study of 52 pregnant women with preeclampsia and 34 women with uncomplicated pregnancy in their third trimester, seroprevalence of recent and long-dated CMV infections was similar in women with preeclampsia and women with normal pregnancy [ 21 ]. In a Norwegian study, no evidence of an effect of CMV IgG seropositivity on the likelihood of developing preeclampsia was found [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Lack of association between cytomegalovirus infection and hypertensive disorders in pregnancy: a case-control study in Durango, Mexico

Alvarado‐Esquivel

Sandoval-Carrillo²,

Vazquez-Alaniz

et al. 2017

EuJMI

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It is not clear whether infection with cytomegalovirus (CMV) is associated with hypertensive disorders in pregnant women. Through a case-control study design, 146 women suffering from hypertensive disorders in pregnancy (cases) and 146 age-matched normotensive pregnant women (controls) were examined for the presence of anti-CMV IgG and IgM antibodies with enzyme-linked immunoassays. IgM seropositive samples were further assayed by enzyme-linked fluorescent assay (ELFA).Anti-CMV IgG antibodies were found in 138 (94.5%) controls and in 136 (93.2%) cases (odds ratio [OR] = 0.78; 95% confidence interval [CI]: 0.30–2.05; P = 0.62). High (>18 IU/ml) levels of anti-CMV IgG antibodies were found in 37.7% of the 138 seropositive controls and in 34.6% of the 136 seropositive cases (OR = 0.87; 95% CI: 0.53–1.43; P = 0.59). Anti-CMV IgM antibodies were found in 1 (0.7%) of the controls but in none of the cases using ELFA (P = 1.0). Seropositivity to CMV was not associated with a previous preeclampsia and was similar among cases regardless their mean systolic and diastolic blood pressures, and mean arterial blood pressure.No serological evidence of an association between CMV infection and hypertensive disorders of pregnancy was found. Further research to elucidate the role of CMV in hypertensive disorders in pregnancy should be conducted.

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Section: Discussionmentioning

confidence: 99%

Lack of association between cytomegalovirus infection and hypertensive disorders in pregnancy: a case-control study in Durango, Mexico

Alvarado‐Esquivel

Sandoval-Carrillo²,

Vazquez-Alaniz

et al. 2017

EuJMI

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“…Strand KM et al [24] studied cytomegalovirus IgG and IgM in plasma sample of a cohort of 1500 women with pre-eclampsia and 1500 healthy pregnant women. They concluded that maternal antibodies to cytomegalovirus was not associated with pre-eclampsia; their result suggested that cytomegalovirus infection was unlikely be a major cause of PE.…”

Section: Discussionmentioning

confidence: 99%

Cytomegalovirus Infection and Pre-Eclampsia

Rădulescu

Huţanu²,

Gabor

et al. 2016

Acta Medica Marisiensis

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Introduction: Pre-eclampsia is a pregnancy-specific disease characterized by hypertension after 20 weeks of gestation and proteinuria. It is a major cause of maternal and perinatal morbidity and mortality. The pathogenesis of pre-eclampsia is not completely understood. In our study we investigated if there is a potential link between cytomegalovirus infection and pre-eclampsia and if cytomegalovirus infection is the triggering factor of pre-eclampsia.Material and methods: This study was carried out in a secondary care hospital between January 2014 and July 2015. We included two groups of pregnant women: 66 with pre-eclampsia and 62 without pre-eclampsia. Enzyme linked immunosorbent assay (ELISA) technique was performed to detect cytomegalovirus Immunoglobulin G levels in maternal serum.Results: The p-value between median values of positive cytomegalovirus IgG in pre-eclamptic women and in controls was not significant (p:0.867). Odds ratio for cytomegalovirus IgG in pre-eclamptic group (OR:0.967; 95%CI:0.535-1.748) do not differ greatly from the value recorded in the control group (OR:1.036; 95%CI:0.571-1.880). The risk for preterm birth in pre-eclamptic women with cytomegalovirus IgG positive values (OR:1.009; 95%CI:0.329-3.090) was greater than those which had term delivery (OR:0.994; 95%CI:0.472-2.095) but the two values are not very high. We found a positive correlation coefficient (0.217) at a “p” value of 0.08 between white blood cells, but a negative correlation coefficient between the percentage of neutrophils and cytomegalovirus infection.Conclusion: Cytomegalovirus infection may be associated with pre-eclampsia but it is unlikely to be the triggering factor of pre-eclampsia.

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“…Mid-pregnancy plasma samples from about 1500 pre-eclamptic women and 1000 controls in MoBa were analyzed with respect to antibody status (IgG and IgM). Adjusted for maternal age, parity and smoking, the odds ratio for pre-eclampsia in women positive for CMV IgG was 0.89 (95% CI: 0.74-1.05) [25]. In nulliparous women a slight, but statistically significant, protective effect of CMV was found.…”

Section: Infection With Cytomegalovirusmentioning

confidence: 87%

Pre-eclampsia research in the Norwegian Mother and Child Cohort Study

Magnus¹,

Trogstad²

2014

Nor J Epidemiol

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Pre-eclampsia is a pregnancy disorder of unknown origin. In Norway, pre-eclampsia is reported in 3 to 4 per cent of registered births. At present, November 2014, a series of investigations into the etiology of preeclampsia have been published internationally from the Norwegian Mother and Child Cohort Study (MoBa), and several studies are ongoing. The intention of this paper is to give a short summary of what has been accomplished, and to discuss future avenues of research concerning causes, mechanisms and consequences of pre-eclampsia. The papers that have been published up to now include seven that concern life-styles (physical activity, tobacco and diet), six that include prior pregnancies, infection, gestational weight gain, toxicants and tryptophan metabolism, and two studies concerning issues of selection and validity. Major findings are that tobacco smoking is only associated with reduced risk of pre-eclampsia when it occurs in the last trimester; that processed food and sugar-sweetened beverages are associated with increased risk while vegetables, vitamin D and probiotics are associated with reduced risk; and that prior induced abortions have the same risk-reducing effect as a prior pregnancy. For future studies, we suggest that better use should be made of the family structure built into MoBa. This includes better use of the discordant pregnancy design. A series of ongoing genetic studies, partly in international consortia, will hopefully open new etiological insights. The indications that pre-eclampsia is related to cardiovascular disease and other complex disorders should be further investigated through systematic follow-up of pre-eclamptic women and controls. Finally, MoBa is eminently suited to study the influences that pre-eclampsia can have on the growing child.This is an open access article distributed under the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Cytomegalovirus antibody status at 17–18 weeks of gestation and pre‐eclampsia: a case–control study of pregnant women in Norway

Cited by 16 publications

References 39 publications

Lack of association between cytomegalovirus infection and hypertensive disorders in pregnancy: a case-control study in Durango, Mexico

Lack of association between cytomegalovirus infection and hypertensive disorders in pregnancy: a case-control study in Durango, Mexico

Cytomegalovirus Infection and Pre-Eclampsia

Pre-eclampsia research in the Norwegian Mother and Child Cohort Study

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