Cytomegalovirus and Other Herpesviruses

Osborn, June E.

doi:10.1016/b978-0-12-262502-2.50020-1

Cited by 37 publications

(35 citation statements)

References 103 publications

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“…In this study, successful transmission appeared to depend on the existence of a persistent, long-term shedding phase during the viral infection cycle, for example in MCMV, MTV, LCMV, MAd and perhaps orthopoxvirus (van der Veen & Mes 1973, Fenner 1982, Lehmann-Grube 1982, Osborn 1982, St-Pierre et al 1987. Viruses lacking the ability to persist within the host were not recorded in captive-bred mice, even for pathogens known to be highly stable in the environment (e.g.…”

Section: Discussionmentioning

confidence: 98%

Serological survey of virus infection among wild house mice (Mus domesticus) in the UK

et al. 2007

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SummaryThe serological prevalence of 13 murine viruses was surveyed among 103 wild-caught and 51 captive-bred house mice (Mus domesticus), originating from several trapping locations in northwest England, using blood samples obtained during routine health screening of an established wild mouse colony. A high proportion of recently caught wild mice were seropositive for mouse hepatitis virus (86%), mouse cytomegalovirus (79%), mouse thymic virus (78%), mouse adenovirus (68%), mouse parvovirus (59%) and minute virus of mice (41%). Seroprevalences of lymphocytic choriomeningitis virus (LCMV), orthopoxvirus, reovirus-3 and murid herpesvirus 4 (MuHV-4, also called murine g-herpesvirus [MHV-68]) were low (3-13%), and no animals were seropositive to Sendai virus, pneumonia virus or polyomavirus. Seroprevalence in wild-caught animals that had been in captivity for over six months was generally consistent with the range found in recently caught wild animals, while seroprevalence was generally much lower in captive-bred mice despite no attempt to prevent viral spread. A notable exception to this was LCMV, which appeared to have spread efficiently through the captive population (both captive-bred and wild-caught animals). Given the known viral life cycles in laboratory mice, it appears that viral persistence in the host was an important contributing factor in the spread of infection in captivity.

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Section: Discussionmentioning

confidence: 98%

Serological survey of virus infection among wild house mice (Mus domesticus) in the UK

et al. 2007

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“…In contrast, varicella zoster virus, which like MCMV is a herpes virus with the ability to persist by establishing latent infection, can survive in small human populations on islands (Black, 1966). Since MCMV establishes latent infection in mice from which periodic reactivation may occur (Osborn, 1982), providing continuing opportunities for transmission, it is likely that the virus could persist in small populations such as those found on islands. A small host population may mitigate against the survival of other murine viruses which do not establish persistent infection.…”

Section: Discussionmentioning

confidence: 98%

Murine Viruses in an Island Population of Introduced House Mice and Endemic Short-Tailed Mice in Western Australia

Moro

Lloyd

Smith

et al. 1999

Journal of Wildlife Diseases

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House mice (Mus domesticus) were recently introduced to Thevenard Island, off the northwest coast of Western Australia. This island is also habitat for an endangered native rodent, the short-tailed mouse (Leggadina lakedownensis). Concerns have been raised that house mice may pose a threat to L. lakedownensis both through competition and as a source of infection. To assess the threat to L. lakedownensis posed by viral pathogens from M. domesticus, a serological survey was conducted from 1994 to 1996 of both species for evidence of infection with 14 common murine viruses (mouse hepatitis virus, murine cytomegalovirus, lymphocytic choriomeningitis virus, ectromelia virus, mouse adenovirus strains FL and K87, minute virus of mice, mouse parvovirus, reovirus type 3, Sendai virus, Theiler's mouse encephalomyelitis virus, polyoma virus, pneumonia virus of mice, and encephalomyocarditis virus) and Mycoplasma pulmonis. Despite previous evidence that populations of free-living M. domesticus from various locations on the Australian mainland were infected with up to eight viruses, M. domesticus on Thevenard Island were seropositive only to murine cytomegalovirus (MCMV). Antibodies to MCMV were detected in this species at all times of sampling, although seroprevalence varied. Infectious MCMV could be isolated in culture of salivary gland homogenates from seropositive mice. In contrast, L. lakedownensis on Thevenard Island showed no serological evidence of infection with MCMV, any of the other murine viruses, or M. pulmonis, and no virus could be isolated in culture from salivary gland homogenates. Although MCMV replicated to high titers in experimentally infected inbred BALB/c laboratory mice as expected, it did not replicate in the target organs of experimentally inoculated L. lakedownensis, indicating that the strict host specificity of MCMV may prevent its infection of L. lakedownensis. These results suggest that native mice on Thevenard Island are not at risk of MCMV infection from introduced house mice, and raise interesting questions about the possible selective survival of MCMV in small isolated populations of M. domesticus.

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“…Not all criteria would have to be met before pathogenicity was accepted but the strongest cases would be expected to meet most. Osborn, 1982;Hamilton, 1982) and murine CMV (MCMV) has been shown to infect all of the organs associated with the human disease (see Table 2). However, since murine CMV does not cross the placenta in mice (Johnson, 1964), congenital infection cannot be studied in this model (this is thought to be due to differences in the structure of the placenta in the mouse and man rather than differences between the two viruses).…”

Section: Oncogenicitymentioning

confidence: 99%

The status of CMV as a human pathogen

Griffiths

Grundy

1988

Epidemiol. Infect.

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Cytomegalovirus (CMV) is a common infectious agent which is well adapted to its host. Following primary infection, which is almost always asymptomatic in people with normal immunity, the virus establishes latency at sites which are unknown. The virus is probably maintained in this latent state by immune surveillance mechanisms since immunosuppression frequently leads to reactivation of virus.Cytomegalovirus has been identified in most anatomical areas of the human body. The aim of this article is to define criteria for pathogenicity so that clinical and experimental data can be reviewed to determine if CMV is likely to cause disease at these various clinical sites. Thus, patients have been shown to die frequentlywithCMV but do they diefromit?

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Cytomegalovirus and Other Herpesviruses

Cited by 37 publications

References 103 publications

Serological survey of virus infection among wild house mice (Mus domesticus) in the UK

Serological survey of virus infection among wild house mice (Mus domesticus) in the UK

Murine Viruses in an Island Population of Introduced House Mice and Endemic Short-Tailed Mice in Western Australia

The status of CMV as a human pathogen

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