Cytology of Postbronchoscopically Collected Sputum Samples and Its Diagnostic Value

Castellà, J; Heras, Pilar de la; Puzo, Carmen; Martínez, Carmen Rodríguez; Lopez, Anselmo; Cornudella, Raimon

doi:10.1159/000194413

Cited by 7 publications

(1 citation statement)

References 5 publications

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“…Many, relatively old, studies have shown a wide range of sensitivities of sputum cytology screening for atypical and/or malignant cells in different study populations with different risks and exposures. Positive results were ranging down to 40% in peripheral tumours and up to 90% in more central cancers [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26]. We found positive sputum results in 21% of our recruited patients.…”

Section: Discussionmentioning

confidence: 85%

Role of I-scan technique in screening for lung cancer in smokers with positive sputum cytology

Abdelhady

Abdallah

2020

Egypt J Bronchol

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Background: Lung cancer has a very poor prognosis and high mortality. Positive sputum for malignant and/or atypical cells warrants the need for fibreoptic bronchoscopy. White light bronchoscopy (WLB) is usually unable to detect preinvasive lesions; therefore, autofluorescence bronchoscopy (AFB) was introduced as a gold standard for detecting such lesions. The aim of this work was to investigate the role of I-scan as a screening tool for cancer in smoker patients showing positive sputum cytology. Results: New suspicious findings under I-scan occurred in 11 patients (36.7%). The overall sensitivity of WLB alone to diagnose malignancy is 23.3%, in contrast to an added sensitivity of 50% when I-scan was combined with white light (p value < 0.05). The specificity of I-scan could not be assessed in the absence of control cases (true negatives). No major complications or deaths occurred. Haemorrhage and bronchospasm were the commonest minor complications. Conclusions: The addition of I-scan to the routine white light examination can increase the overall sensitivity of bronchoscopic screening in cases of sputum suspicious for malignancy if put in experienced hand. The suggested increase in procedure duration due to the combined use of I-scan and white light bronchoscopy is not associated with life-threatening complications.

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Section: Discussionmentioning

confidence: 85%

Role of I-scan technique in screening for lung cancer in smokers with positive sputum cytology

Abdelhady

Abdallah

2020

Egypt J Bronchol

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Indications and Contraindications in Flexible Bronchoscopy

Browning

Turner

Wang

2012

Flexible Bronchoscopy

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Effective use of bronchoscopy and sputa in the diagnosis of lung cancer

Bender

Cherock

Sotos

1985

Diagnostic Cytopathology

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The records of 134 patients who underwent bronchoscopy at the Forbes Health System hospitals between January 1, 1982 and December 31, 1983 were reviewed. The number of pre- and postbronchoscopy sputa obtained on each patient, final diagnosis, and follow-up for 6 to 30 months were obtained. Tissue obtained at bronchoscopy yielded a diagnosis of malignancy in 71 of 84 (84.5%) patients who received that final diagnosis. Addition of postbronchoscopy sputa examination increased the yield to 73 of 84 (86.9%). Prebronchoscopy sputa contributed no diagnoses beyond those made by bronchoscopically obtained material. The cost to the patient of examining pre- and postbronchoscopy sputa in addition to bronchoscopically obtained cytologic and biopsy material is 70% higher than that of examining bronchoscopically obtained material alone. Indirect costs of increased hospital stay may also be significant. We propose early bronchoscopy without prebronchoscopy sputa in cases where there is clinical suspicion of lung cancer. Postbronchoscopy sputa should be obtained, but only processed for microscopic examination if the bronchoscopically obtained material does not yield a diagnosis.

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Cytology of Postbronchoscopically Collected Sputum Samples and Its Diagnostic Value

Cited by 7 publications

References 5 publications

Role of I-scan technique in screening for lung cancer in smokers with positive sputum cytology

Role of I-scan technique in screening for lung cancer in smokers with positive sputum cytology

Indications and Contraindications in Flexible Bronchoscopy

Effective use of bronchoscopy and sputa in the diagnosis of lung cancer

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