Cytology and Mesenchymal Pathology:<i>How Far Will We Go?</i>

Ryan, Mitchell R.

doi:10.1093/ajcp/106.5.561

Cited by 26 publications

(26 citation statements)

References 15 publications

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“…3 - 4 Nevertheless, the accuracy and therapeutic significance of FNAB for histologic subtyping of soft tissue sarcomas is less clear. 5 Furthermore, establishing a specific histologic subtype seems easier for some cytomorphologic groups of sarcomas (eg, small round cell) than for others (eg, pleomorphic cell) and often influences initial therapy.…”

Section: Introductionmentioning

confidence: 99%

Fine-Needle Aspiration Biopsy of Soft Tissue Sarcomas: A Cytomorphologic Analysis With Emphasis on Histologic Subtyping, Grading, and Therapeutic Significance

et al. 1999

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A b s t r a c tAlthough fine-needle aspiration biopsy (FNAB) of soft tissue sarcomas has been used effectively for preoperative evaluation and documentation of local recurrences and metastases, its role in the initial diagnosis of primary soft tissue sarcomas is still not accepted widely. 12 In experienced hands, sensitivity and specificity rates exceed 90% for the determination of malignancy and approach the rates obtained with frozen section interpretation.3 -4 Nevertheless, the accuracy and therapeutic significance of FNAB for histologic subtyping of soft tissue sarcomas is less clear. 5 Furthermore, establishing a specific histologic subtype seems easier for some cytomorphologic groups of sarcomas (eg, small round cell) than for others (eg, pleomorphic cell) and often influences initial therapy.2 -6 We describe our experience with the use of FNAB as the initial diagnostic procedure to guide therapy for 67 primary soft tissue sarcomas, emphasizing the accuracy of histologic subtyping among specific cytomorphologic groups. It is not our purpose to provide detailed cytomorphologic descriptions of various sarcoma subtypes; for such information, the reader is referred to other publications that more adequately address these topics. -2 Materials and MethodsWe retrospectively reviewed 73 consecutive FNAB soft tissue sarcoma specimens (63 primary tumors, 9 metastases, and 1 local recurrence) from 67 patients, none of whom had a previously established sarcoma diagnosis. All cytologic samples were obtained without general anesthesia using 23-and 25-gauge needles by the standard manual method (62 aspirates) and computed tomographic-guided or ultrasoundguided needle placement (11 aspirates) at Wake Forest

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Section: Introductionmentioning

confidence: 99%

Fine-Needle Aspiration Biopsy of Soft Tissue Sarcomas: A Cytomorphologic Analysis With Emphasis on Histologic Subtyping, Grading, and Therapeutic Significance

et al. 1999

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“…2 Several factors have been implicated such as the low volume of soft tissue and bone lesions in most practices, the overlapping cytomorphologic features in a variety of entities, and the wide variability in reported sensitivities, specificities, and inadequacy rates over the past 2 to 3 decades, [2][3][4][5][6][7][8][9][10][11][12][13][14] leading to skepticism regarding the accuracy and utility of this technique. [15][16][17] The aims of the current study were to investigate the utility of FNA in the diagnosis of soft tissue and bone lesions in a large series of cases from a tertiary medical center with an active FNA service, and to highlight some of the challenges. This study of 1114 cases is the largest series of bone and soft tissue FNAs reported in the literature with emphases on the utility, limitations, and diagnostic pitfalls.…”

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confidence: 99%

Diagnostic accuracy and limitations of fine‐needle aspiration cytology of bone and soft tissue lesions

Khalbuss

Teot

Monaco

2010

Cancer Cytopathology

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BACKGROUND: Fine-needle aspiration (FNA) cytology is increasingly being used as a diagnostic modality for soft tissue and bone lesions. These diagnoses can be challenging because of a variety of factors, including interpretation and sampling issues. This study investigates the diagnostic utility of FNA biopsy, in addition to the diagnostic pitfalls, in soft tissue and bone cytopathology. METHODS: We retrospectively reviewed the soft tissue and bone FNAs over a 4-year period (2004)(2005)(2006)(2007)(2008), along with available ancillary studies, pathological follow-up, and clinical data. The cases with a cytologic-histologic discrepancy were then reviewed. RESULTS: A total of 1114 soft tissue and bone FNAs were identified. Of the 1114 aspirates, 525 (47%) were positive for malignant cells, 505 (45.5%) were benign aspirates (including 189 benign lesions/neoplasms), 37 (3.5%) were inadequate, 34 (3%) had atypical cells, and 13 (1%) were suspicious for malignancy. Of the 586 cases (53%) with follow-up, including 445 cases with histological follow-up and 141 with ancillary studies, the overall sensitivity was 96%, the specificity was 98%, the positive predictive value was 99%, and the negative predictive value was 92%. A total of 15 false negatives and 3 false positives were identified with errors because of sampling (9 cases), interpretation (7 cases), and screening (2 cases). CONCLUSIONS: This large series demonstrates that there can be a high sensitivity and specificity in diagnosing bone and soft tissue lesions by FNA. Our data supports prior studies in the literature in showing that FNA cytology can be a valuable method for diagnosing these lesions. Cancer (Cancer Cytopathol) 2010;118:24-32.

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“…18 We have developed an RT-PCR assay to detect a specific SYT-SSX fusion in archival cytologic specimens and have shown that the specific chimeric transcript is detected in more than 90% of cytologic cases, although some of the cases were stored for 17 to 20 years. Such a high sensitivity is almost equal to that reported for the use of frozen materials.…”

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confidence: 99%

Detection ofSYT-SSXFusion Transcript in Synovial Sarcoma Using Archival Cytologic Specimens

et al. 1999

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Cytology and Mesenchymal Pathology:How Far Will We Go?

Cited by 26 publications

References 15 publications

Fine-Needle Aspiration Biopsy of Soft Tissue Sarcomas: A Cytomorphologic Analysis With Emphasis on Histologic Subtyping, Grading, and Therapeutic Significance

Fine-Needle Aspiration Biopsy of Soft Tissue Sarcomas: A Cytomorphologic Analysis With Emphasis on Histologic Subtyping, Grading, and Therapeutic Significance

Diagnostic accuracy and limitations of fine‐needle aspiration cytology of bone and soft tissue lesions

Detection ofSYT-SSXFusion Transcript in Synovial Sarcoma Using Archival Cytologic Specimens

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