Cytology and Histochemistry of the Burkitt Lymphoma

Wright, D. H.

doi:10.1038/bjc.1963.7

Cited by 101 publications

(30 citation statements)

References 9 publications

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“…The majority were lymphocytic with males affected more commonly than females (4: 2). No lesion histologically similar to that described by O'Conor (1961) and later by Wright (1963) was found.…”

Section: Part Isupporting

confidence: 66%

A Search for the Burkitt Lymphoma in Tropical Central America

Rowe¹,

Johnson²

1964

Br J Cancer

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IN the last six years an unusual cancer affecting children in Africa (Burkitt, 1958) has come to the attention of the scientific community. This cancer is particularly noteworthy because of its high incidence in African children (the commonest childhood cancer in Africa) and its peculiar geographic distribution on that continent. It is characterized by an unusual anatomic distribution; the jaws being involved in the majority of cases and a nearly universal sparing of the peripheral lymph nodes. The African lymphoma syndrome is significant within the context of the total cancer problem in that the epidemiology is highly suggestive of viral etiology. Support for this concept is given by the age distribution, apparent lack of racial predilection, and geographical distribution which is related to altitude, temperature and humidity (Burkitt, 1962).A study of the prevalence and distribution of the Burkitt lymphoma outside Africa has not yet been reported. Considering the similarity of geographic distribution between the lymphoma in Africa and tropical vector-born viral diseases on that continent, and considering further that for the most part these same vectorborn viral diseases are endemic to the tropical areas of Central America, this area seemed most likely to contain information about the prevalence and distribution of this entity in the Western hemisphere. This study was initiated to gather information about the Burkitt lymphoma on this hemisphere.The present study was conducted in two parts. The first, a safari by dug-out canoe into the tropical jungles of Darien, Panama, searching clinical evidence of the tumor, and the second part, a search through the histopathologic collection at

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Section: Part Isupporting

confidence: 66%

A Search for the Burkitt Lymphoma in Tropical Central America

Rowe¹,

Johnson²

1964

Br J Cancer

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“…We considered fibroblasts, follicular dendritic cells (since BL is a malignancy of germinal centre B-cell origin 5 ) and macrophages which constitute the major non-malignant cell component of BL. 34 In addition, we assessed the effects of the activated T-cell surface molecule CD40-ligand since activated T cells are also known to infiltrate BL 23 and CD40-ligation is known to generate anti-apoptosis signals in BL cells. 35 ± 37 CD40-mediated survival, however, was also accompanied by gross phenotypic changes, including CD54 and CD95 upregulation along with cell-growth arrest, comparable with observations in other studies in which ligation of CD40 on BL cells was achieved either by T-cell-anchored or soluble CD40L or by anti-CD40 antibody.…”

Section: Discussionmentioning

confidence: 99%

Micro-environmental factors in the survival of human B-lymphoma cells

2000

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Burkitt lymphoma (BL) cells retain a high inherent propensity to undergo apoptosis indicating that net growth of the tumour population in vivo is likely to be influenced profoundly by its micro-environment. Here we investigate micro-environmental factors that affect BL-cell survival in vitro. We show that survival, and consequently net production, of tumour cells is enhanced by autocrine factors and, to a greater extent, by paracrine factors provided by relevant stromal elements of the tumour (fibroblasts and follicular dendritic cells) and by macrophages. Promotion of BL-cell survival by paracrine elements was mediated by cell/cell contact and by short-range soluble factor(s). IL-4, IL-10 and TNF-a promoted, whereas TGF-b1 inhibited, tumour-cell production. Macrophages engaged in phagocytosis of apoptotic BL cells were less effective than untreated macrophages in supporting net expansion of BL populations. These results suggest that the net production of tumour cells in BL is supported by multiple micro-environmental factors that modulate apoptosis. Cell Death and Differentiation (2000) 7, 59 ± 69.

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“…Subsequently, pathologists were able describe its distinctive pathological features, leading to the recognition of Burkitt lymphoma in nonendemic areas (86,87). Discovery of the association of Burkitt lymphoma with MYC may not have been possible without this accurate pathological and clinical description.…”

Section: The Microscope As a Tool For Disease Discoverymentioning

confidence: 99%

The Microscope as a Tool for Disease Discovery—A Personal Voyage

Jaffe

2017

Annu. Rev. Pathol. Mech. Dis.

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This review reflects the trajectory of my career in hematopathology, and my personal reflections on scientific advances in the field. During the course of more than 40 years, the approach to classification of hematological malignancies has evolved from descriptive approaches, based on either cytological or clinical features, to a modern approach, which incorporates cutting-edge technologies. My philosophy has focused on defining individual diseases, an approach that can best lead to an understanding of molecular pathogenesis. To quote Carolus Linnaeus (1, p. 19), the father of taxonomy, "The first step in wisdom is to know the things themselves; this notion consists in having a true idea of the objects; objects are distinguished and known by classifying them methodically and giving them appropriate names. Therefore, classification and name-giving will be the foundation of our science."

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Cytology and Histochemistry of the Burkitt Lymphoma

Abstract: Images Figs. 1-4

Cited by 101 publications

References 9 publications

A Search for the Burkitt Lymphoma in Tropical Central America

A Search for the Burkitt Lymphoma in Tropical Central America

Micro-environmental factors in the survival of human B-lymphoma cells

The Microscope as a Tool for Disease Discovery—A Personal Voyage

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